Zhongshan Daxue xuebao. Yixue kexue ban正常眼压性青光眼（NTG）是原发性开角型青光眼（POAG）的独立亚型，特征为眼压正常（＜21 mmHg）但出现进行性视神经病变、视网膜神经节细胞（RGC）凋亡及视野缺损。其发病机制主要为非眼压依赖，核心涉及以基因与线粒体为中心的过程，包括RGC退变、神经炎症、线粒体功能障碍和遗传易感性。基于此，本文系统梳理NTG的非眼压依赖、基因驱动机制，重点解析OPTN、TBK1、FOXC1与OPA1如何通过线粒体功能紊乱、胶质细胞激活、炎症信号、细胞凋亡与轴突退化等途径导致RGC损伤。其中 ...
胡昊, 梁亮
doaj
Regulatory effect of PINK1/Parkin axis on mitophagy in isoniazide-induced hepatocellular injury. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2022 Xu Y, Li Y.
europepmc +1 more source
Mechanism of Sirt3/NLRP3 pathway in paraquat-induced inflammatory response of THP-1 macrophages [PDF]
Objective To explore the role and mechanism of the Sirt3/NLRP3 pathway in macrophages during the inflammatory response of human monocyte-derived macrophages induced by paraquat(PQ), with the aim of providing new perspectives for treating lung injury ...
FANG Sijun
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Anti-aging Activity and Composition Analysis of Grape Pomace Oil Prepared by Acid-Thermal Pretreatment Combined with Low-Temperature Continuous Phase-Transition Extraction [PDF]
To simultaneously improve the extraction rate of grape pomace oil and the retention rate of active substances, this study combined acid-thermal (AT) pretreatment with low-temperature continuous phase-transition extraction (LCPE) to prepare grape pomace ...
ZOU Xiaojun, GUO Chaowan, XIAO Jie, YANG Jinling, CAO Yong, LIU Xiaojuan
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Zhongshan Daxue xuebao. Yixue kexue ban随着全球人口老龄化进程的加快，肌少症作为一种以骨骼肌质量、力量与躯体功能持续性下降为特征的老年综合征，已成为严重威胁老年人健康和生活质量的重要公共卫生问题。其发生发展过程涉及多层次、跨系统的细胞与分子机制。近年来研究发现，程序性细胞死亡（PCD）在骨骼肌稳态维持、代谢调节与组织修复中发挥核心作用。凋亡、自噬、焦亡与铁死亡等典型PCD形式通过活性氧（ROS）积聚、线粒体功能障碍与铁稳态破坏等关键节点相互串扰，驱动肌纤维丢失、肌肉功能减退及慢性炎症反应，是肌少症发生发展的重要病理基础 ...
史雪珂, 冯晓东
doaj
Effect of mitochondrial oxidative stress on lead-exposed inflammatory activation of microglia [PDF]
Objective To investigate the role and mechanism of mitochondrial oxidative stress in lead (Pb)-induced microglial inflammation. Methods BV2 microglia cells were divided into 4 groups and treated with 0 μmol/L (control group), 1 μmol/L, 5 μmol/L and 10 ...
CHEN Kaiju +7 more
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Regulation of reactive oxygen species on the mitophagy of human periodontal ligament cells through the PINK1/Parkin pathway under starvation. [PDF]
Hua Xi Kou Qiang Yi Xue Za Zhi, 2022 Fan Z, Jin K, Li S, Xu J, Xu X.
europepmc +1 more source
Platycoside G1 Inhibits Hepatocyte Senescence by Regulating Autophagy [PDF]
To investigate the effects of platycoside G1 (PG1) on senescent cells, it was determined that PG1 exerts a specific inhibitory effect on the senescent phenotype of hepatocytes by employing β-galactosidase staining and the cell counting kit-8 (CCK-8 ...
LI Yiquan, LI Yaru, LIU Yunyun, ZHAO Renshuang, ZHAO Zhehao, WU Changzheng, ZHANG Biao
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Study on the mechanism of mitochondrial dysfunction and CPT1A/ERK signal transduction pathway regulating malignant behavior in breast cancer [PDF]
Background and purpose: The overexpression of carnitine palmitoyl transferase 1A (CPT1A) is related to the poor prognosis of breast cancer, and it can promote the utilization of fatty acids by mitochondria and maximize triphosphate (ATP) production ...
JIANG Dan, SONG Guoqing, WANG Xiaodan
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