野生动物学报褐色脂肪组织（brown adipose tissue，BAT）是哺乳动物重要的适应性产热器官。BAT内有丰富的线粒体和多种脂质成分。线粒体形态的维持，包括融合与分裂，与产热效率密切相关，影响细胞能量代谢，而脂质代谢在提供产热底物中扮演核心角色。BAT产热能力在冬眠哺乳动物的深冬眠和阵间觉醒期间存在快速且显著的周期性变化，然而其中的调节机制尚不明确。本综述从线粒体动力学和脂质成分变化的角度综合了当前对BAT产热机制的理解，探讨了哺乳类冬眠动物BAT线粒体形态和脂质成分在冬眠和非冬眠状态下的变化 ...
陈欣钰, 付有涛, 杨明, 邢昕
doaj +2 more sources
Zhongshan Daxue xuebao. Yixue kexue ban亨廷顿病（HD）是常染色体显性遗传的神经退行性疾病，由亨廷顿蛋白（HTT）基因CAG重复序列异常扩增引起。其主要临床表现为运动障碍、认知下降和精神症状。随着基础研究不断深入，线粒体功能障碍，包括能量代谢异常，氧化应激，线粒体动力学异常，钙稳态失调等方面与HD之间的关系愈发引起研究者的重视。在本篇综述中，我们讨论了线粒体功能障碍的多种形式与HD之间存在的联系，旨在强调线粒体功能障碍在HD疾病发生发展过程中的重要作用。
赵江宇, 郭兴
doaj
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Nan Fang Yi Ke Da Xue Xue BaoLin X, He Y, Shi H, Liu J, Hu H.
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