Results 11 to 20 of about 13,813 (166)

SARS‐CoV‐2 infection as cause of in‐utero fetal death: regional multicenter cohort study

Ultrasound in Obstetrics &Gynecology, Volume 62, Issue 6, Page 867-874, December 2023., 2023
ABSTRACT Objective Placental infection with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) can lead to placental insufficiency and in‐utero fetal death (IUFD). The objective of this study was to confirm and quantify the extent to which fetoplacental infection with SARS‐CoV‐2 is a cause of fetal death.
M. Nkobetchou, M. Leruez‐Ville, T. Guilleminot, N. Roux, G. Petrilli, F. Guimiot, M.‐H. Saint‐Frison, I. Deryabin, Y. Ville, V. Faure‐Bardon   +9 more
wiley   +1 more source

Fatty acid β‐oxidation and mitochondrial fusion are involved in cardiac microvascular endothelial cell protection induced by glucagon receptor antagonism in diabetic mice 脂肪酸β‐氧化和线粒体融合参与胰高血糖素受体拮抗剂对糖尿病小鼠心脏微血管内皮细胞的保护作用

Journal of Diabetes, Volume 15, Issue 12, Page 1081-1094, December 2023., 2023
Highlights Glucagon receptor (GCGR) monoclonal antibody (mAb) improves cardiac function and attenuates microvascular damage in db/db mice. GCGR mAb ameliorates the oxidative stress of cardiac microvascular endothelial cells in diabetic mice. GCGR mAb counteracts the diabetes‐induced upregulation of carnitine palmitoyltransferase 1B, optic atrophy type ...
Peng Wang, Rui Wei, Xiaona Cui, Zongzhe Jiang, Jin Yang, Lingyun Zu, Tianpei Hong   +6 more
wiley   +1 more source

Antibody response to inactivated COVID‐19 vaccine in patients with type 2 diabetes mellitus after the booster immunization 2型糖尿病患者接种增强剂次灭活COVID‐19疫苗后的抗体反应

Journal of Diabetes, Volume 15, Issue 11, Page 931-943, November 2023., 2023
Highlights Similar antibody response to COVID‐19 inactivated vaccine between healthy controls (HCs) and patients with type 2 diabetes mellitus (T2DM) after a booster shot vaccine within 6 months. Patients with T2DM have reduced antibody response after receiving the third dose of the COVID‐19 vaccine for more than 6 months. Both HCs and T2DM showed poor
Haolong Li, Yao Wang, Xiaomeng Li, Siyu Wang, Xinxin Feng, Xinhua Xiao, Yongzhe Li   +6 more
wiley   +1 more source

Successful surgical removal of a pheochromocytoma in a mare via trans‐costal approach

Equine Veterinary Journal, Volume 55, Issue 6, Page 1012-1020, November 2023., 2023
Abstract Background Pheochromocytomas have been previously reported in horses, but successful antemortem diagnosis and surgical removal without recurrence of clinical signs have not been described. Objective To report the clinical presentation, diagnostic evaluation, surgical technique, anaesthetic management and post‐operative care of a mare diagnosed
Thomas J. O'Brien, Lynn M. Pezzanite, Elizabeth V. Acutt, Allison C. Vilander, Diana M. Hassel, Rachel C. Hector, Dean A. Hendrickson   +6 more
wiley   +1 more source

Histopathological characterisation of trunk‐dominant canine pemphigus foliaceus, and comparison with classic facial and insecticide‐triggered forms

Veterinary Dermatology, Volume 34, Issue 5, Page 425-440, October 2023., 2023
Background – While the clinical features were described recently, the histopathological characterisation of trunk‐dominant canine pemphigus foliaceus (PF) is lacking, and whether it differs from classic facial or insecticide‐triggered PF is unknown. Hypothesis/Objectives – This study describes the histopathological findings of trunk‐dominant PF, and ...
Natalie Katharina Yvonne Gedon, Petra Bizikova, Thierry Olivry, Ekaterina Mendoza‐Kuznetsova, Ursula Oberkirchner, James Benjamin Robertson, Keith Emerson Linder   +6 more
wiley   +1 more source

Canine melanocytes: Immunohistochemical expression of melanocytic markers in different somatic areas

Veterinary Dermatology, Volume 34, Issue 4, Page 284-297, August 2023., 2023
Background – Melanoblasts originate in the neural crest from where they migrate to peripheral tissues and differentiate into melanocytes. Alteration during melanocyte development and life can cause different diseases, ranging from pigmentary disorders and decreased visual and auditory functions, to tumours such as melanoma.
Ilaria Porcellato, Margherita Orlandi, Adriana Lo Giudice, Monica Sforna, Luca Mechelli, Chiara Brachelente   +5 more
wiley   +1 more source

HLA‐DR3 mediated CD4 T cell response against GAD65 in type 1 diabetes patients HLA‐DR3介导的CD4 T细胞对1型糖尿病患者GAD65的应答

Journal of Diabetes, Volume 15, Issue 7, Page 607-621, July 2023., 2023
Highlights The CD4 T cells of type 1 diabetes (T1D) patients particularly having HLA‐DRB1*03‐DQA1*05‐DQB1*02 haplotype are reactive against a particular region of the glutamic acid decarboxylase (GAD65) protein. GAD65 peptides encompassing 288–308 amino acid positions (peptide pool 2) may be favored by the HLA‐DR3 molecule for presentation to CD4 T ...
Neihenuo Chuzho, Neetu Mishra, Nikhil Tandon, Uma Kanga, Gunja Mishra, Akanksha Sharma, Narinder K. Mehra, Neeraj Kumar   +7 more
wiley   +1 more source

Hybrid Probiotic Hydrogel With Curcumin‐Loaded MnO2 Nanoparticles Enhances Diabetic Wound Healing Through Multimodal Microenvironmental Regulation

Rare Metals, EarlyView.
ABSTRACT Skin wound injuries are often accompanied by bacterial infections and severe inflammation. Especially, M1‐type macrophages at the wound site can trigger a cascade of inflammatory responses, mediating a vicious cycle of inflammation. Meanwhile, hypoxia further exacerbates vascular damage and constriction in the wound microenvironment, thereby ...
Xianfeng Wang, Yuwen Shangguan, Hao Nan, Lingze Chen, Chencheng Gu, Litao Yan, Huan Li   +6 more
wiley   +1 more source

Engineering a Tumor‐Targeted MgH2@Lip/PD‐L1 Nanoplatform for Synergistic Hydrogen Therapy and Immune Activation

Rare Metals, EarlyView.
ABSTRACT Lung cancer remains the leading cause of cancer‐related deaths worldwide, yet immune checkpoint blockade (ICB) is often compromised by an immunosuppressive tumor microenvironment (TME) with acidosis, hypoxia, and poor T cell infiltration. Here, we develop a TME‐responsive nanoplatform (MgH2@Lip/PD‐L1) that couples hydrogen gas therapy with PD ...
Xuyu Gu, Ming Deng, Tao Ge, Li Xu, Xinnan Xu, Kaiqi Jin   +5 more
wiley   +1 more source

Efficacy of Der f 2/Zen 1‐LAMP1 Plasmid‐Based Vaccine Immunotherapy in Dogs With Atopic Dermatitis: A Proof‐of‐Concept Study

Veterinary Dermatology, EarlyView.
Background: DNA‐based vaccination rapidly induces strong cellular and humoral immune responses, which may be enhanced by inclusion of lysosomal‐associated membrane protein‐1 (LAMP). Objectives: This proof‐of‐concept study evaluated the efficacy and safety of a Der f 2/Zen 1‐LAMP‐based DNA vaccine immunotherapy in client‐owned dogs with nonseasonal AD ...
Petra Bizikova, Chigusa Matsumoto, Shoji Ogino, Toshihiro Tsukui, Kim Love, Marcy Murphy, Ina Herrmann   +6 more
wiley   +1 more source