Results 11 to 20 of about 1,307,470 (171)
[Hesperetin Alleviates Doxorubicin-Induced Cytotoxicity in H9c2 Cells by Activating SIRT1/NRF2 Signaling]. [PDF]
Sichuan Da Xue Xue Bao Yi Xue Ban, 2023 目的 本研究旨在探讨橙皮素（hesperetin, Hes）能否通过调控沉默信息调节因子1（silent information regulator 1, SIRT1）/核转录因子E2相关因子2（nuclear transcription factor E2-related factor 2, NRF2）信号减轻氧化应激改善阿霉素（doxorubicin, DOX）诱导的H9c2心肌细胞毒性。 方法 采用DOX诱导的H9c2心肌细胞毒性模型，随机分为4组：对照组（Control）、DOX处理组（DOX）、
Li X, Yan A, Chang J, Li F, Zhu J.
europepmc +2 more sources
地鼠和人胚肺上皮细胞对致癌 剂毒性和染色体损伤反应 [PDF]
Zhongshan Daxue xuebao. Yixue kexue ban, 1989 为了检查人染色体比啮齿类动物染色体更为稳定的假设, 我们比较了人和叙利亚地鼠胚胎肺上皮细胞对诱导性细胞毒性, 染色体畸变和姐妹染色体交换( SC E ) 的敏感性。接种细胞一天后, 用不同剂量乙基亚硝基脉( EN U ) 处理2 小时, 然后用标准法检查其染色体畸变和S C E 率, 用细胞计数法测定细胞毒性。染色体 畸变和S C E 率均表明清楚的剂量依赖关系, 而且在地鼠细胞的发生率明显高于人细胞, 但两种细胞表明相同的细胞毒性反应 ...
doaj +1 more source
CEA 重组痘苗病毒免疫巨噬细胞抑制CEA 阳性肿瘤的机制 [PDF]
Zhongshan Daxue xuebao. Yixue kexue ban, 2000 【目的】探讨癌胚抗原重组痘苗病毒(CEA-rV)对癌胚抗原(CEA)阳性肿瘤的抑瘤机制。【方法】使用我室构建 的CEA-rV 腹腔接种C57BL/ 6 小鼠3 次, 6 周后, 取其腹腔巨噬细胞(MΥs)转输给携带CEA 阳性肿瘤的受体小鼠, 同时检测供 体MΥs 及受体脾细胞的体外细胞毒活性。【结果】供体MΥs 体外细胞毒活性无明显增加, 但体内却能明显抑制CEA 阳性肿 瘤的生长, 受体脾细胞对同一靶细胞的杀伤活性亦明显增强。【结论】经CEA-rV 接种处理的小鼠MΥs 可能通过其抗原提呈 ...
赵 青 +3 more
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Zhongshan Daxue xuebao. Yixue kexue ban, 1992 采用单个细胞水平细胞毒方法研究比较了正常人外周血自然杀伤(NK)细胞对不同靶细胞结合与杀伤活性的差别。发现NK细胞对人胚胎成纤维细胞和低分化鼻咽癌(CNE-2)细胞的结合率明显高于对人成骨肉瘤细胞(OS-732)和PLC/PRF/5人肝癌细胞,结合并杀伤新鲜切除人肝癌细胞,而对同一病人的癌周肝细胞则无作用;在同一株CNE-2细胞中,NK多选择性地与核浆比例大的靶细胞结合。以上结果说明NK细胞在发挥自然细胞毒过程中具有一定的选择性,选择性地结合并杀伤分化差或幼稚的靶细胞。
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SARS‐CoV‐2 infection as cause of in‐utero fetal death: regional multicenter cohort study
Ultrasound in Obstetrics &Gynecology, Volume 62, Issue 6, Page 867-874, December 2023., 2023 ABSTRACT Objective Placental infection with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) can lead to placental insufficiency and in‐utero fetal death (IUFD). The objective of this study was to confirm and quantify the extent to which fetoplacental infection with SARS‐CoV‐2 is a cause of fetal death.
M. Nkobetchou +9 more
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Journal of Diabetes, Volume 15, Issue 12, Page 1011-1019, December 2023., 2023 Highlights Weight gain with insulin therapy in the early period may be negatively related to the occurrence and duration of remission by altering insulin sensitivity. Interventions to prevent rapid weight gain and conserve insulin sensitivity in the early stages of type 1 diabetes mellitus may be beneficial for the development and maintenance of ...
Dicle Canoruc Emet +9 more
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Zhongguo shiyan zhenduanxue, 2022 噬血细胞综合征（HPS），又名噬血细胞性淋巴组织细胞增多症（HLH），是由于细胞因子风暴导致的淋巴细胞、巨噬细胞增生和活化，并伴有血细胞吞噬现象的一种综合征。依据病因，又可将嗜血细胞综合征分为原发性和继发性两种。原发性噬血细胞综合征为遗传相关型，表现为常染色体或X连锁隐性遗传，伴有相关基因遗传；继发性噬血细胞综合征常继发于风湿免疫性疾病、各种病毒如EB病毒、细菌、
闻宇, 马静茹, 周芮
doaj
Rare Metals, Volume 45, Issue 10, October 2026.ABSTRACT Gram‐negative (G−) bacterial infections, fueled by intrinsic antibiotic resistance stemming from their unique outer membrane architecture, pose a critical global clinical challenge. This study introduces a pioneering dual‐enzyme‐mimetic nanotherapy based on NaYbF4 nanoparticles (NaYbF4 NPs) that achieves synergistic antibacterial and anti ...
Yuxiang Zhang +6 more
wiley +1 more source
Rare Metals, Volume 45, Issue 10, October 2026.ABSTRACT The immunosuppressive milieu of hepatocellular carcinoma (HCC) remains a major obstacle to durable antitumor responses. Mechanical‐energy‐driven piezocatalysis provides a noninvasive means of inducing oxidative damage and immunogenic tumor destruction; however, inefficient utilization of piezoinduced charges and insufficient localization of ...
Mingjian Zhang +7 more
wiley +1 more source
Rare Metals, Volume 45, Issue 9, September 2026.ABSTRACT Esophageal squamous cell carcinoma (ESCC) remains associated with frequent local recurrence and distant metastasis despite advances in radiochemotherapy and immunotherapy, highlighting the need for therapeutic strategies that improve both local tumor control and systemic antitumor immune responses.
Dongdong Wang +7 more
wiley +1 more source