Results 31 to 40 of about 1,307,470 (171)
Biodegradable Mg Alloys: Enhancing Anti‐tumor Immunity in Cancer Therapy
ABSTRACT Magnesium (Mg) alloys, as biodegradable metallic materials with excellent biocompatibility and mechanical properties, demonstrate significant advantages. In the field of immunotherapy, they present a promising potential option for enhancing therapeutic outcomes and hold broad prospects for application.
Can Feng +8 more
wiley +1 more source
作者运用电磁脉冲使细胞电穿孔并结合抗肿瘤药物观察细胞的毒性 ,比较了电穿孔组与对照组细胞的抗肿瘤药物胞质毒性的差异 ,发现电穿孔组比对照组的胞质毒性显著提高 .结果说明 ,利用电穿孔可提高抗肿瘤药物的细胞毒性 ,为治疗肿瘤提供了新的途径 .
杨孔 +10 more
doaj
ABSTRACT Objective To estimate the residual risk of maternal–fetal transmission after primary cytomegalovirus (CMV) infection in the periconceptional period or the first trimester in women treated with valacyclovir, and to assess whether the presence of glycoprotein B2 (gB2)‐specific immunoglobulin (Ig)‐G antibodies on immunoblot analysis refines fetal
K. O. Kagan +6 more
wiley +1 more source
ABSTRACT Lung cancer remains the leading cause of cancer‐related deaths worldwide, yet immune checkpoint blockade (ICB) is often compromised by an immunosuppressive tumor microenvironment (TME) with acidosis, hypoxia, and poor T cell infiltration. Here, we develop a TME‐responsive nanoplatform (MgH2@Lip/PD‐L1) that couples hydrogen gas therapy with PD ...
Xuyu Gu +5 more
wiley +1 more source
目的研究球形纳米金粒子对人成纤维细胞的体外细胞毒性作用;方法应用柠檬酸钠还原法制备纳米金溶胶,将纳米金溶胶制备成不同浓度的含金培养液,采用MTT法体外检测其对人成纤维细胞的细胞毒效应。结果培养液中加入不同浓度纳米金溶胶(1.875 mg.L-13、.750 mg.L-17、.500 mg.L-11、5.000 mg.L-13、0.000 mg.L-1)各组细胞相对增殖率(RGR)分别为112.653%,111.293%,89.524%,72.109%,46.803%,加入15.000 mg.L-1、30.
宋文植 +5 more
doaj
Boron Difluoride Chelated Aminoanthraquinone Photosensitizer for Type I Photodynamic Therapy
ABSTRACT Type I photosensitizers capable of generating cytotoxic reactive oxygen species (ROS), with reduced oxygen dependence under photoirradiation, are regarded as a promising phototherapeutic approach for hypoxic solid tumors. Herein, based on the electron donor of 9‐phenyl‐carbazole (Cz) and the electron acceptor of anthraquinone (AQ ...
Tian Zhang +8 more
wiley +1 more source
用紫外线灭活的草鱼呼肠孤病毒 (GCRV)诱导鲫鱼囊胚细胞 (CAB)能产生一种高滴度的抗病毒物质。这种物质在 5 6℃及 pH 2~ 11稳定 ;对胰蛋白酶敏感 ;抗病毒活性受被保护细胞的密度、培养温度及保护时间的影响 ;不能被GCRV的特异性抗体中和 ;无直接杀病毒作用 ;抗病毒机制依赖于细胞内RNA和蛋白质的合成 ;在多种鱼类培养细胞中具有抑制病毒作用。这些特性与哺乳类α/ β干扰素一致 ...
张义兵,王铁辉,李戈强,贾方钧,俞小牧
core +1 more source
目的 检测血清固定梅毒患者外周血T淋巴细胞亚群及NK淋巴细胞 ,探讨梅毒患者血清固定与细胞免疫的相关性。方法 应用流式细胞仪检测 2 2例血清固定梅毒患者外周血T淋巴细胞亚群及NK淋巴细胞 ,并与 30例健康人群的检测结果相对照。结果 血清固定梅毒患者外周血CD3及CD4淋巴细胞均低于对照组 ,差异有显著性 (P
杨日东 +6 more
doaj
Is parvovirus B19 infection upsurge in 2023–2024 associated with adverse pregnancy outcome?
ABSTRACT Objective A surge in parvovirus B19 infections has been reported in 2023–2024 across Europe and the USA, raising concerns about the associated perinatal risks. The aim of this study was to compare perinatal outcomes following maternal parvovirus B19 infection during the 2023–2024 period with those from a pre‐2023 cohort.
S. Prasad +22 more
wiley +1 more source
采用0.1,1.0,10.0μg/mL的微囊藻毒素-RR(MC-RR)处理烟草BY-2悬浮细胞,测定了细胞活力、细胞内蛋白质含量、可溶性糖含量、硝态氮含量及总磷含量,并且检测了酸性磷酸酶(ACP)的活力变化情况.结果表明,中、高浓度毒素处理细胞2d后,细胞活力及蛋白质含量与对照相比均显著下降.高浓度MC-RR处理降低了胞内可溶性糖的含量,暴露2d后仅为对照的45.57%;低浓度MC-RR处理在后期增加了胞内可溶性糖含量.高浓度毒素处理细胞4d后,细胞内硝态氮含量显著低于对照;中 ...
刘永定, 黄文敏, 邢伟, 李敦海
core

