Results 21 to 30 of about 1,307,470 (171)
Research Progress and Prospect of Single‐Atom Materials in Tumor Catalytic Therapy
Rare Metals, Volume 45, Issue 9, September 2026.ABSTRACT
Tumor catalytic therapy (TCT), an emerging therapeutic modality, exerts specific cytotoxic effects on tumor cells by catalyzing endogenous substances within the tumor microenvironment (TME)—including hydrogen peroxide (H2O2), glucose, and glutathione—to generate reactive oxygen species (ROS) or deplete protective biomolecules.Youyu Wang, Shuwei Zhang, Yangke He, Liang Liang, Kegang Jia +4 morewiley +1 more sourceA Strontium‐Based Polyphenol Nanozyme Reverses Cisplatin‐Related Acute Kidney Injury Through Near‐Infrared‐Enhanced PI3K/AKT Pathway Inhibition and Macrophage M2 Directional Polarization
Rare Metals, Volume 45, Issue 9, September 2026.ABSTRACT
Cisplatin‐related acute kidney injury (CP‐AKI) is a serious complication of cisplatin (CP) treated patients with cancer with high morbidity and mortality rates. It is directly related to the abnormal accumulation of CP in renal tubular epithelial cells, causing metabolic toxicity, DNA damage, and oxidative stress.Minghe Jiang, Ruikai Zhu, Shurong Chen, Xuwen Pan, Leiyuan Peng, Yaohui Huang, Wenquan Lv, Mingjing Yin, Xiaoxuan Guan, Mingyang Jiang, Ming Gao, Wei Wang, Yan Liu +12 morewiley +1 more source微囊藻毒素对Hela细胞和Vero细胞的毒性效应
, 1999 ＭＣＹＳＴ－ＬＲ，ＭＣＹＳＴ－ＲＲ，ＭＣＹＳＴ－ＹＲ稀释后的毒素溶液处理Ｈｅｌａ细胞和Ｖｅｒｏ细胞后得到如下结果：１．３种毒素溶液对培养的Ｈｅｌａ细胞均有明显的抑制作用和毒性作用，其毒性作用与浓度成正比．致死细胞边缘不整齐不规则，细胞呈脱水状态．倒置显微镜下可见细胞变黑无折光性．高浓度毒素溶液（包括ＭＣＹＳＴ－ＬＲ，－ＲＲ和－ＹＲ３个样品）作用细胞２４ｈ后，细胞完全致死脱落，３个样品间无明显差别；２．毒素对Ｖｅｒｏ细胞也具一定的抑制和毒性作用，但不如对Ｈｅｌａ细胞的作用强烈；３．在相同稀释浓度下 ...赵以军,王旭,黄国锦,夏苇,程凯,赵进,甘小妮core +1 more source慢性HBV感染患者抗原表位特异性CTL与ALT水平无关
Zhongshan Daxue xuebao. Yixue kexue ban, 2006 [目的]通过定量分析慢性乙型肝炎患者体内乙型肝炎病毒（HBV）特异性的细胞毒性T淋巴细胞,探讨特异性细胞毒性T淋巴细胞水平与血清丙氨酸氨基转移酶水平和病毒复制状态的关系.[方法]从慢性乙型肝炎患者外周血分离外周血单个核细胞（PBMC）,用HLA-A2限制的HBcAg抗原表位肽-五聚体复合体及CD8单克隆抗体染色后,用流式细胞仪检测HBV特异性的细胞毒性T淋巴细胞,同时检测患者的肝功能和定量分析HBV DNA.[结果]32例HLA-A2阳性的慢性乙型肝炎患者外周血均可检测到HBV特异性的细胞毒性T淋巴细胞,邓洪, 韩晓燕, 陈幼明, 张富程, 彭晓谋, 高志良, 姚集鲁 +6 moredoaj Spatiotemporally Adaptive Bilayer Silk Fibroin–Polyvinyl Alcohol–Metformin Composite Coating on Biodegradable Zinc for Orthopedic Applications
Rare Metals, Volume 45, Issue 7, July 2026.ABSTRACT
Biodegradable zinc (Zn)‐based materials are considered promising candidates for orthopedic applications because of their favorable mechanical properties, controllable biodegradability, and good biosafety profiles. However, their clinical translation is limited by early‐stage corrosion‐induced cytotoxicity and inflammation, as well as ...Jinlong Mao, Wentai Zhang, Jingtao Dai, Zhaozhao Zhang, Junyu Qian, Jinjing Liu, Wenjie Tao, Yuanhao Wang, Dorothea Alexander, Guojiang Wan +9 morewiley +1 more sourcePreparation of Highly Bioactive Nanolignin via Dopamine Mannich Modification and Its Synergistic Effects With Zn2+ in PVA Hydrogels
Rare Metals, Volume 45, Issue 7, July 2026.ABSTRACT
Lignin is a natural non‐toxic polyphenolic macromolecule, which shows inherent antioxidant and broad‐spectrum antibacterial activities. However, due to the low content and the high bond dissociation energy of phenolic hydroxyl groups (Ar‐O·H), its antioxidant and antibacterial activities are relatively weak, which limits its application as a ...Meiling Han, Hui Hui, Yi Yang, Yan Wang, Danli Zhou, Yuebin Xi, Yu Jing, Pingxian Feng, Fan‐Gong Kong, Huan Wang, Weijun Yang +10 morewiley +1 more source副黏病毒感染后程序性细胞死亡的作用
浙江大学学报. 医学版副黏病毒是一类重要的呼吸道病原体，在儿童感染性疾病中具有重要临床意义。其感染过程中可诱导多种形式的程序性细胞死亡（PCD），这些PCD形式在病毒复制、传播及宿主免疫应答中发挥关键作用，显著影响病毒的生命周期及疾病进展。一方面，PCD通过清除被感染细胞有助于限制病毒扩散并激活宿主免疫应答，从而增强抗病毒防御能力；另一方面，过度或异常的细胞死亡可能导致组织损伤和免疫紊乱，为病毒复制提供有利环境，进而加重病情。如细胞凋亡通过外源性与内源性通路参与感染控制，同时亦可能被病毒操控以增强其扩散能力 ...刘 叶, 汪 一龙, 何 志旭, 赵 正言 +3 moredoaj +1 more sourceInfluence of Alkaline Earth Barium on the Microstructure, Corrosion Behavior, and Cytocompatibility of Biodegradable Zinc
Rare Metals, Volume 45, Issue 7, July 2026.ABSTRACT
Biodegradable Zn‐based alloys are promising candidates for temporary implants, yet excessive Zn2+ release during degradation may induce cytotoxicity and adverse tissue responses. In this study, Zn‐xBa alloys (x = 0.1 wt%, 0.5 wt%, 1.0 wt% and 3.0 wt%) were developed to achieve controlled corrosion behaviors with improved biocompatibility.Liu‐Dang Fang, Meng‐Meng Mao, He Huang, Zhi‐Pei Tong, Qian‐Ying Jia, Qing‐Gong Jia, Jin Xiao, Shao‐Kang Guan, Dong Bian, Yu‐Feng Zheng +9 morewiley +1 more sourceChanging trends in prenatal screening and treatment of cytomegalovirus infection in France: 7‐year national cohort study (2017–2023)
Ultrasound in Obstetrics &Gynecology, Volume 67, Issue 6, Page 756-763, June 2026.ABSTRACT Objectives
Cytomegalovirus (CMV) is the leading cause of congenital infectious neurosensory impairment. We aimed to present national epidemiological data on maternal CMV infection during pregnancy in France, focusing in particular on primary infection in the periconceptional period or first trimester, and to assess the impact of changes in ...P. Coste‐Mazeau, E. Ribot, S. Hantz, Y. Ville, M. Leruez‐Ville, S. Alain, the French Congenital Infection database group, Maeva Anciaux, Laurent Andreoletti, Julie Arata‐Bardet, Carine Arlicot, Dominique Astruc, Jocelyne Attia, Marie‐Stéphanie Aubelle, Christelle Auvray, Bassel Bachour, Sonanda Bailleux, Nathalie Banaszkiewicz, Adeline Baron, Audrey Baudesson de Chanville, Manon Baudry, Agnès Beby‐Defaux, Alexandra Benachi, Melinda Benard, Yasmina Benmalek, Guillaume Benoist, Géraldine Benoit, Clotilde Bertrand, Florence Biquard, Delphine Body‐Bechou, Emilie Bouissou, Brahim Boumahni, Thomas Bourlet, Elise Bouthry, David Boutolleau, Marie Pierre Brechard, Caroline Bressollette, Olivier Brissaud, Marine Butin, Anne‐Sophie Cabaret‐Dufour, Romain Cahierc, Sandrine Caillot‐Vaudoyer, Odile Camard, Margaux Canaguier, Isabelle Cannavo, Clément Castella, Julie Cattin, Caroline Chessa, Marie‐Thérèse Cheve, Marianne Coicaud, Laurence Contin, Marianne Coste‐Burel, Sophie Couderc, Anne‐Marie Darras, Amélie Delabaere, Delphine Delayer, Mathilde Demeyere, Joelle Dendale, Anny Dewilde, Murielle Dobrzynski, Chloé Dole, Chloé Epiard, Véronique Equy, Laurence Fagour, Frederic Faibis, Benoit Fetiveau, Axel Fichez, Christelle Follet‐Bouhamed, Justine Formet, Vincent Foulongne, Loriane Franchinard, Emilie Frobert, Denis Gallot, Patricia Garcia, Isabelle Garrigue, Catherine Gaudy‐Graffin, Stéphanie Gouarin, Ann‐Claire Gourinat, Veronique Grezard, Michele Gueneret‐Bru, Jérôme Guinard, Frédérique Hay, Sophie Henault, Céline Homatter, Nadira Houhou, Cyril Huissoud, Véronique Jacomo, Gaelle Jambon, Eugénie Jolivet, Saodat Karimova, Blandine Keller, Sophie Ketterer‐Martinon, Fedia Khlif Masmoudi, François Kieffer, Bérengère Kireche, Anne‐Sophie L'Honneur, Jean‐Marc Labaune, Imad Labbassi, Marie‐Edith Lafon, Gisèle Lagathu, Stéphane Lastere, Hélène Laurichesse, Mouna Lazrek, Gwenaelle Le Bouar, Camille Le Pors, Claudine Le Vaillant, René Lebeaupin, Elodie Lecorps, Quentin Lepiller, Justine Lerat, Marine Letrecher, Nicolas Leveque, Emmanuelle Levine, Sophie Levrier, David Leyssene, Julien Lupo, Nadia Mahjoub, Anne‐Marie Maillotte, Sandrine Marioli, Julien Marlet, Stéphanie Marque Juillet, Manon Marquet, Charlotte Masias, Marco Millones Gonzales, Philippe Minodier, Nicolas Mottet, Eve Mousty, Sébastien Moutton, Anca Moza, Fatiha Najioullah, Anne‐Laure Nerre, Marie‐France Olieric, Isabelle Parent, Anne Paris, Christophe Pasquier, Estelle Perdriolle‐Galet, Franck Perrotin, Delphine Pesenti, Jean‐Charles Picaud, Olivier Picone, Sylvie Pillet, Léa Pilorge, Didier Pinquier, Veronique Poirier‐Cartron, Lucie Poisson, Perrine Prier, Catherine Queiros‐Da‐Silva, Thibaud Quibel, Harisoa Ramaholimihaso, Fabienne Raskin, Christel Regagnon, Mathilde Roffi, Thierry Rousseau, Anne‐Hélène Saliou, Adèle Schiby, Nathalie Schnepf, Christine Segard, Anaïs Soares, Morgane Solis, Robin Stephan, Natacha Teissier, Cyrielle Thonnon, Cynthia Trastour, Joelle Troussier, Anne Sylvie Valat, Christelle Vauloup‐Fellous, Véronique Venard, Valérie Vequeau‐Goua, Laura Verdurme, Mathilde Vermont, Marie Gabrielle Vigue, Marie Vincienne, Vladimir Vladimirov, Jean‐Baptiste Vuillemenot, Anne Sophie Weingertner, Eric Welter, Christine Zandotti +176 morewiley +1 more source碳纤维增强聚醚醚酮（CFR/PEEK）和钛合金的细胞毒性比较
Zhongguo shiyan zhenduanxue, 2009 目的通过体外细胞毒性试验,对碳纤维增强聚醚醚酮（CFR/PEEK）和钛合金两种材料的细胞毒性进行比较。方法培养人皮肤成纤维细胞（HSF）、人成骨细胞（HFOB）和鼠成纤维细胞（NIH3T3）,提取两种材料浸提液。利用CCK-8测量细胞增殖和细胞毒性,采用SPASS12.0对数据进行统计分析,Microsoft Excel软件绘制细胞生长曲线。结果两种材料对三种细胞的增殖均有轻微抑制,但材料组和对照组之间并无显著差异;两种材料对三种细胞均无细胞毒性。结论碳纤维增强聚醚醚酮具有和钛合金相同的细胞相容性 ...刘军, 朱庆三, 姜志刚, 吴敏飞, 郭永刚 +4 moredoaj
