Results 11 to 20 of about 1,600 (128)
, 2021 运动训练是脑卒中后康复治疗的主要手段。运动训练可以促进脑卒中后神经功能的恢复，其作用目前普遍认为与神经可塑性有关，但具体机制未明。运动训练的神经可塑性机制是当前脑卒中康复研究领域的热点问题。运动训练可以调节脑卒中后脑内血流动力学变化、血管新生、神经炎症反应、营养因子分泌、神经细胞死亡及新生等。本文基于国内外研究，探讨脑卒中后最适的运动干预方案，并结合我们团队在运动训练促进脑卒中后神经功能恢复方向所做的系列研究工作 ...
胡昔权
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低强度聚焦超声触发PLGA阿霉素在细胞内空化增加乳腺癌细胞死亡
Zhongshan Daxue xuebao. Yixue kexue ban, 2021 目的探讨低强度聚焦超声能否触发聚乳酸-羟基乙酸共聚物（PLGA）包裹阿霉素在细胞内的空化作用以增加4T1肿瘤细胞的死亡。方法采用双乳化溶剂蒸发法制备了负载阿霉素的聚乳酸-羟基乙酸共聚物（PLGA）纳米气泡。设立细胞内释药组，细胞外释药组，传统给药组，单独超声组和对照组。用流式细胞仪检测各组细胞的死亡情况，用细胞活力检测试剂盒（CCK8）检测各组的细胞增殖，细胞划痕检测各组的侵袭情况。结果超声组细胞核的红色荧光平均强度高于对照组，差异具有统计学意义（t=16.627，P<0.001）；聚乳酸 ...
黄盘辉, 罗琼, 严飞, 李绍林
doaj
Research progress on influence of PM2.5 on allergic rhinitis [PDF]
, 2023 Allergic rhinitis (AR) is one of the main chronic inflammatory diseases that pose a global threat. Its symptoms persist for a long time, recur, and seriously affect the physical and mental health of the patients.
Huai WEI +4 more
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Physiological function of nerve injury-induced protein 1 and its role in relevant diseases [PDF]
, 2023 Nerve injury-induced protein 1 (NINJ1) is a cell-surface adhesion molecule containing an extracellular adhesion domain and two transmembrane domains. NINJ1 is named for its original discovery in damaged nerve endings.
LU Xinwu +4 more
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Advances in basic research, clinical diagnosis and treatment of bladder cancer in 2022 [PDF]
, 2023 Bladder cancer (BCa) is a common malignant tumor of the urinary tract. Significant progress has been made in both basic and clinical research on BCa, which has further elucidated the drivers of BCa development at the gene and protein levels, and explored
ZHENG Shengfeng, ZHU Yiping, YE Dingwei
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Analysis of Absorption Characteristics of Walnut Peptides by Everted Rat Sacs and Identification of Antioxidant Peptides [PDF]
, 2023 This study investigated the absorption characteristics of
Dan WU +6 more
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Gasdermin D is required for pyroptosis and secretion of interleukin-1β [PDF]
, 2016 炎性小体是细胞内由caspase-1，ASC，NALP等组成的蛋白复合体，也是先天免疫系统的一个重要组成。炎性小体被激活后会促进白介素1β（IL-1β）和IL-18的剪切与分泌，并触发细胞焦亡的发生。细胞焦亡是近年来发现并证实的一种新的程序性细胞死亡方式，其特征为依赖于caspase-1，并伴随有促炎症因子的释放。尽管其在先天免疫和内毒素休克方面扮演着重要角色，但细胞焦亡被诱导发生的机制仍不清楚。本文通过基于CRISPR-Cas9的基因敲除方法鉴定到了gasderminD（GSDMD ...
万浩强
core
Rare Metals, Volume 43, Issue 11, Page 6006-6022, November 2024.Graphical abstract AbstractCisplatin resistance is the main cause for the failure of cancer therapy. To solve the problem, we proposed to develop a novel human serum albumin (HSA) nanoplatform to integrate chemotherapy, photothermal therapy (PTT) and immunotherapy.
Xue‐Yu Man +7 more
wiley +1 more source
, 2016 中国科协生命科学学会联合体:免疫细胞在病原菌的清除中发挥关键作用。病原菌入侵免疫细胞后能引起免疫细胞的炎性坏死即细胞焦亡(pyroptosis),这是机体的重要免疫防御反应,在清除病原感染和内源危险信号中发挥重要作用。细胞焦亡由炎性蛋白酶caspase介导,但具体机制完全未知 ...
韩家淮
core
Gasdermin D is an executor of pyroptosisand required for interleukin-1secretion [PDF]
, 2015 炎症小体是先天免疫系统中一类重要的胞内信号复合体。炎症小体的激活可以引发白介素1β（IL-1β）和白介素18（IL-18）的成熟和分泌，同时引发细胞焦亡。Caspase-1和caspase-11(人源同源蛋白caspase-4/5)分别在经典炎症小体和非经典炎症小体信号通路中起关键作用。本实验中，我们通过利用高灵敏度定量质谱技术，发现蛋白gasderminD（GSDMD）是炎症小体复合物的另一重要组成成分，它会随着NLRP3炎症小体激活剂的刺激进入炎症小体复合体。我们通过敲除GSDMD基因 ...
何琬婷
core