Results 51 to 60 of about 1,600 (128)
Quercetin regulates phenotypic transformation of vascular smooth muscle cells induced by angiotensin Ⅱ through Nrf2/HO-1 signaling pathway [PDF]
ObjectiveTo investigate the protective effect and mechanism of quercetin (QR) against angiotensin Ⅱ (Ang Ⅱ)-induced injury and phenotypic transformation in vascular smooth muscle cells (VSMCs).
Mamatimin ABDURESHIT, Wei ZHU
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Progress on effects of BaP exposure on female reproductive system and pathogenic mechanisms [PDF]
Benzo[a]pyrene (BaP) is the most abundant environmental pollutant among polycyclic aromatic hydrocarbons (PAHs), and is widely distributed in air, water, soil, barbecue, and fried foods. Human beings are inevitably exposed to BaP. Studies have shown that
Qianqian GAO, Xiaoling FENG
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ABT737通过延迟宫颈癌细胞放射后DNA损伤修复及诱导凋亡而增敏放疗
Zhongshan Daxue xuebao. Yixue kexue ban, 2013 【目的】 探讨类似BH-3的小分子物质ABT737诱导增敏放疗的作用及其分子机制?【方法】噻唑蓝法(MTT)检测不同浓度ABT737对HeLa细胞的生长抑制作用;细胞克隆形成实验检测ABT737联合放疗对放疗的增敏作用;免疫荧光法检测γ-H2AX观察DNA损伤修复情况;流式细胞术检测细胞凋亡;免疫印迹法检测Caspase-3?PARP的表达观察凋亡?【结果】与对照组相比,ABT737能显著抑制宫颈癌HeLa细胞的增殖(P < 0.05),并呈浓度依赖性,其IC50为15.7 μmol/L ...
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, 2019 蛋白磷酸酶2A(PP2A)是真核细胞内广泛表达的丝/苏氨酸蛋白磷酸酶家族成员之一,通过去磷酸化作用参与外源物诱导细胞毒性损伤和致癌过程中关键调控蛋白的可逆磷酸化,进而抑制绝大多数丝/苏氨酸激酶的活性。近年来,PP2A在线粒体质量控制(MQC)中的作用逐渐被认识,广泛参与线粒体生物发生、线粒体动态、线粒体氧化还原平衡和线粒体自噬等重要生物学过程,对拓展MQC相关蛋白翻译后修饰在以线粒体为核心枢纽的信号流中的研究具有重要意义。本文重点阐述PP2A介导的去磷酸化机制在MQC调控中的作用 ...
林忠宁, 林育纯, 车琳
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Zhongguo cuzhong zazhi目的 探讨丁苯酞（3-N-butylphthalide，NBP）对氧糖剥夺后星形胶质细胞氧化应激的保护作用及调节机制。 方法 采用CTX TNA2大鼠星形胶质细胞构建氧糖剥夺模型，通过细胞计数试剂盒-8型评估细胞活性，检测超氧化物歧化酶（superoxide dismutase，SOD）活性与丙二醛（malondialdehyde，MDA）含量以评估氧化应激水平；使用实时荧光定量PCR检测细胞焦亡相关基因[胱天蛋白酶（cysteine aspartic acid specific protease ...
高雨田，刘文娟，金玉玲，王克健（GAO Yutian, LIU Wenjuan, JIN Yuling, WANG Kejian）
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Progress on the Anti-inflammatory, Anti-cancer Activities and Mechanism of Action of Fucoxanthin [PDF]
Fucoxanthin is a carotenoid, reddish-brown in color, which is mainly derived from marine organisms such as brown algae and diatoms, and has aroused extensive scientific interest due to its unique chemical structure and abundant biological activities ...
Fanzheng ZENG +5 more
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Zhongguo shiyan zhenduanxue目的本研究利用机器学习构建子宫内膜癌（UCEC）细胞焦亡相关的预后模型及筛选敏感药物。方法通过TCGA数据库获取511例UCEC临床样本的基因表达谱，随机将UCEC样本分为训练集和验证集。使用ssGSEA算法计算UCEC患者的细胞焦亡评分，基于该评分将患者分为High-Pyroptosis组和Low-Pyroptosis组。应用limma包识别High-Pyroptosis组和Low-Pyroptosis组中的差异表达基因。应用单因素Cox回归和机器学习 ...
姚广, 吕晓, 刘畅
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Zhongguo shiyan zhenduanxue, 2015 乳腺癌的发生发展为多基因参与和多阶段协同作用的结果[1]。远处转移是导致乳腺癌患者死亡的主要因素[2]。提高乳腺癌微转移的检出率,对判断患者的预后和合理选择治疗方案,提高患者生存率均有重要意义。在乳腺癌患者的骨髓和外周血液中评价游离的肿瘤细胞已经成为一个肿瘤转移的研究焦点。在1869年,Ashworth[3]提出了循环肿瘤细胞的概念。循环肿瘤细胞是指自发或因诊疗操作进入外周血循环的肿瘤细胞。在1889年,Paget[4 ...
王丽娟, 张研, 吕昭宝
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Factors Associated with Site-specific Distribution of Glioblastoma [PDF]
The treatment of glioblastoma, the most prevalent malignant tumor in the central nervous system, poses considerable challenges. Glioblastoma multiforme, classified as a grade Ⅳ highly malignant brain glioma by the World Health Organization, is typically ...
BAO Hongbo, LI Wenting, LIANG Peng
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Recent Advances in Extraction Methods, Biological Activities and Application in Foods of Puerarin [PDF]
Puerarin is the major bioactive ingredient of Pueraria lobata, a traditional medicinal and edible plant in China, and it exerts multiple biological activities, including cardiovascular protection, anti-diabetes, anti-tumor, neuroprotection, bone ...
HUANG Shihan, LIU Xinyu, LIU Yanxin, XU Huaming, YU Yiting
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