Results 31 to 40 of about 13,468 (164)
Zhongguo shiyan zhenduanxue, 2018 结核病是一种由结核分枝杆菌引起的慢性传染性疾病,现已被WHO列为需要重点控制的三大类传染病之一[1-3]。近些年来结核病的耐药率不断升高,耐药性结核病已严重威胁人类的健康[4]。因此,对结核病进行早诊断、早治疗、控制传染源至关重要[5]。本研究采用T-SPOT.TB和CLEIA两种方法检测疑似结核病患者的结核分枝杆菌的感染情况,并对两组结果进行对比分析,探讨其检测的可靠性及对结核病诊断的临床价值。
宋丽娜 +5 more
doaj
Multicolor Melting Curve Analysis-based on Detection of Pyrazinamide-Resistant Mycobacterium tuberculosis [PDF]
, 2017 结核病是由结核分枝杆菌感染人体的慢性传染性疾病。2015年新增患病人数高达1040万，有140万人死于结核病。在众多治疗结核病药物中，吡嗪酰胺是较早发现的一线抗结核药物之一。在酸性环境下，吡嗪酰胺可以抑制巨噬细胞内半休眠结核分枝杆菌。随着吡嗪酰胺广泛使用，耐受吡嗪酰胺的结核病危害面广，因此吡嗪酰胺耐药突变检测的研究急需开展。针对上述问题，本文利用探针熔解曲线分析技术对结核分枝杆菌吡嗪酰胺耐药突变检测展开研究。 第一章绪论，首先简要概述现今世界结核病概况，再介绍耐药结核病诊断和治疗的方法 ...
李梓
core
Equine Veterinary Journal, Volume 57, Issue 2, Page 398-405, March 2025.Abstract Background Cervical articular process joint (CAPJ) therapy is advocated for horses with neck disorders. Several ultrasound‐guided CAPJ techniques have been described in cadaver studies with 72%–89% intra‐articular injection accuracy; however, the CAPJ injection accuracy in clinical equine practice has not been extensively reported.
Elizabeth J. Davidson +3 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2015 1998年,世界卫生组织（WHO）将结核病列为全球重点防控的三大传染病之一[1]。截止2009年,全世界有超过5000万人已感染结核菌,其中的10%最终会成为活动性肺结核患者,每年约有300万人死于结核病[2]。中国结核病发病人数为131万,占全球的13.9%,在全球22个结核病高负担国家中居第2位,同时也是全球27个耐多药结核病流行严重的国家之一[3]。现今 ...
王瑞 +9 more
doaj
Ultrasound in Obstetrics &Gynecology, Volume 65, Issue 2, Page 226-234, February 2025.ABSTRACT Objectives Ultrasound is the first‐line imaging modality of the pelvis in the pediatric and adolescent gynecology (PAG) population. Ultrasound findings in pre‐ and postpubertal PAG patients differ from those in adults. Diagnostic models for adnexal pathology have not been validated in this cohort.
N. Cooper +15 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2010 目的评价结核杆菌蛋白芯片对肺结核的诊断价值及其影响因素。方法对痰涂片阳性肺结核病患者结核杆菌蛋白芯片和胸部CT扫描结果进行对比,分析肺结核病变范围和类型等因素对结核杆菌蛋白芯片检测的影响。结果结核杆菌蛋白芯片阳性率72.0%,CT诊断阳性率为90.0%,两种方法同时检测阳性率达到96.0%;多个肺野肺结核的结核杆菌蛋白芯片阳性率高于单个肺野 ...
曹军皓, 黄前川, 赵冰红
doaj
Studies on the solution structure , dynamics and functional analysis of Ribosomal Protein S1 of M. tuberculosis [PDF]
, 2016 自德国细菌学家RobertKoch于1882年发现结核分枝杆菌（M.tuberculosis）是引起人类结核病的病原菌以来，结核病（Tuberculosis，TB）一直是全球死亡率和发病率最高的传染性疾病之一。随着全球耐多药结核菌株的出现和蔓延，改进现有药物、寻求新药靶以及研发新型的抗结核病药物一直是一个重要课题。 目前，治疗结核病的主要策略是联合用药，而吡嗪酰胺（Pyrazinamide，PZA）是联合用药中不可缺少的前体药物。PZA进入人体内被结核杆菌细胞摄取，在细胞内的酸性环境中被吡嗪酰胺酶 ...
傅静琳
core
Veterinary Dermatology, Volume 36, Issue 1, Page 83-91, February 2025.Background – Feline Bowenoid in situ carcinoma (BISC) is frequently associated with Felis catus papillomavirus‐2 (FcaPV‐2). Although surgical excision of BISC is expected to be curative, recurrent lesions are reported and it is not known whether it is a consequence of incomplete surgery or residual viral load.
Francesca Abramo +7 more
wiley +1 more source
Solution Structure Calculation and Dynamics Characterization of Ribosomal Protein S1 from Mycobacterial tuberculosis [PDF]
, 2016 1882年，德国细菌学家RobertKoch发现结核分枝杆菌（M.tuberculosis，M.tb）是引起人类结核病的病原菌。结核病（Tuberculosis，TB）仍是全球死亡率和发病率最高的传染性疾病之一。结核病的治疗仍面临着前所未有的挑战，即使有四个一线药物的联合使用，包括不可缺少的前体药物-吡嗪酰胺（Pyrazinamide，PZA）。PZA经被动扩散进入结核杆菌体内，随后被吡嗪酰胺酶（Pyrazinamidase，PZase）催化水解为有抗菌活性的吡嗪酸（Pyrazinoicacid，POA）
黄碧玲
core
Ultrasound in Obstetrics &Gynecology, Volume 65, Issue 1, Page 85-93, January 2025.ABSTRACT Objective Accurate differentiation between placenta accreta spectrum (PAS) and uterine‐scar dehiscence with underlying non‐adherent placenta is often challenging, even for PAS experts, both prenatally and intraoperatively. We investigated the use of standardized two‐dimensional grayscale ultrasound and Doppler imaging markers in ...
T. Adu‐Bredu +3 more
wiley +1 more source