Results 51 to 60 of about 13,468 (164)
NMR Based Structure, Function and Dynamics analysis of Ribosomal Protein S1 from Mycobacterium Tuberculosis [PDF]
, 2017 WHO2016年结核病全球报告指出，结核病已成为死亡率高于艾滋病(HIV/AIDS)的全球性高危致死性疾病。随着全球耐多药结核菌株的出现和蔓延，寻找新药物靶标蛋白和研发抗结核新药已成为近些年研究的热点。抗结核一线药物吡嗪酰胺，可以将治疗周期由传统的9-12个月缩短为6个月，尽管它在临床上使用60多年，然而直到近期才发现它主要是通过其生理活性形式吡嗪酸来发挥抗菌治病功能，即：吡嗪酸通过特异性地结合核糖体蛋白MtRpsA的C端结构域，抑制tmRNA与MtRpsA相互作用 ...
樊漪
core
Veterinary Dermatology, Volume 35, Issue 4, Page 375-385, August 2024.Background – Perianal fistulas are painful ulcers or sinus tracts that disproportionately affect German shepherd dogs and are proposed as a spontaneous animal model of fistulising Crohn's disease. Objectives – To characterise the rectal and cutaneous microbiota in German shepherd dogs with perianal fistulas and to investigate longitudinal shifts with ...
Christine L. Cain +6 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2015 结核病(TB)是一类由结核分枝杆菌引起的慢性肉芽肿性的炎症,结核分枝杆菌可感染全身多个系统,其中最常见的是肺结核。据统计,当前全球已有1/3的人口为结核病患者[1],每年约800万-1000万名患者最终发展成活动性结核病患者,每年约200-300万人死于肺结核[2]。近年来,由于耐多药结核病(MDR-TB)的流行与传播 ...
王志佳, 石少敏, 李丹
doaj
Fetal and neonatal neuroimaging in twin–twin transfusion syndrome
Ultrasound in Obstetrics &Gynecology, Volume 63, Issue 6, Page 746-757, June 2024.ABSTRACT Objectives To describe the types of brain injury and subsequent neurodevelopmental outcome in fetuses and neonates from pregnancies with twin–twin transfusion syndrome (TTTS). Additionally, to determine risk factors for brain injury and to review the use of neuroimaging modalities in these cases.
M. S. Spruijt +8 more
wiley +1 more source
陕西省87株耐药结核分枝杆菌寡核苷酸基因分型和耐药性分析 [PDF]
, 2018 目的对陕西87例耐药结核分枝杆菌进行分型研究,了解不同基因型在陕西的流行情况及耐药相关性。方法收集陕西省结核分枝杆菌耐药菌株87株,采用Spoligotyping方法对结核分枝杆菌临床分离株进行基因分型。结果 87株耐药结核分枝杆菌中北京家族占86.21%(75/87),非北京家族占13.79%(12/87);非北京基因型中,T家族(T1、T2、T2-3、T3)占9.20%(8/87),Manu家族占1.15%(1/87),新发现基因型占3.45%(3/87)。北京家族和非北京家族的单耐药、多耐药 ...
张天华 +5 more
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Target product profiles: tests for tuberculosis treatment monitoring and optimization [PDF]
, 2023 The World Health Organization has developed target product profiles containing minimum and optimum targets for key characteristics for tests for tuberculosis treatment monitoring and optimization.
Brigden, Grania +26 more
core
World Medical &Health Policy, Volume 16, Issue 2, Page 116-133, June 2024.Abstract Although tobacco control efforts have been successful at reducing the rate of tobacco use in the general population, rates of use among low‐income populations persist. As a leader in tobacco control efforts, the U.S. state of California recently issued regulations regarding comprehensive tobacco cessation service requirements for state ...
Sara W. Yoeun +2 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2016 肺结核是严重危害人类健康的呼吸道传染病,也是全球关注的公共卫生和社会问题。高校是一个特殊的群体,人口密集、学习生活集中,使大学生成为结核病的高发群体。近年来由于结核杆菌的生物学特性和社会等因素,结核病发病呈上升趋势,高校也不例外。有文献报道在山东、江苏、浙江等地高校学生中相继出现肺结核爆发疫情问题[1-3],严重影响了学生的身心健康。因此加强结核病防治工作 ...
任艳蕾, 于淑艳, 张立夏
doaj
Engineering the Plasmodium berghei genome via CRISPR/Cas9 system [PDF]
, 2015 疟疾是由雌性按蚊叮咬而感染疟原虫所引起的虫媒传染病。2013年全球因感染疟疾而死亡的人数达58万，是世界公共卫生的沉重负担，主要易感人群是撒哈拉沙漠以南非洲地区5岁以下免疫力低下的儿童。其中感染恶性疟原虫引起的重症脑型疟最为严重且致死率极高。啮齿动物疟原虫是研究疟原虫与宿主互作的良好模型，伯氏疟原虫ANKA株系（PlasmodiumbergheiANKA）感染小鼠能够产生实验型脑疟症状，已广泛用于恶性疟原虫的致病机理研究。虽然疟原虫的转染技术有二十年的历史了，但由于缺乏高效的基因修饰工具 ...
肖波
core
Update on the role of cytokines and chemokines in canine atopic dermatitis
Veterinary Dermatology, Volume 35, Issue 1, Page 25-39, February 2024.Background – Cytokines and chemokines play central roles in the pathogenesis of canine atopic dermatitis (cAD). Numerous studies have been published and provide new insights into their roles in cAD. Objectives – To summarise the research updates on the role of cytokines and chemokines in the pathogenesis of cAD since the last review by the ...
Chie Tamamoto‐Mochizuki +6 more
wiley +1 more source