谷胱甘肽还原酶影响结肠癌代谢及预后：一项基于蛋白组学与微阵列芯片分析的研究
Zhongguo shiyan zhenduanxue目的 探讨谷胱甘肽还原酶(Glutathione reductase, GSR)对结肠恶性肿瘤代谢的影响及其对结肠癌患者的预后价值。方法 通过蛋白组学差异分析获得结肠癌组织和正常结肠上皮组织的差异蛋白，并通过富集分析和蛋白-蛋白相互作用网络(PPI)分析鉴定代谢通路中的关键蛋白，进行生存分析和临床信息相关性分析。收集120例结肠癌患者手术病理标本制作组织微阵列芯片，进行免疫组织化学染色。结果 蛋白组学差异分析共鉴定出1 209个差异表达蛋白。KEGG富集分析显示，差异蛋白显著富集于代谢通路 ...
吴惧 +4 more
doaj
[High expression of CFL1 and phospho-CFL1 predicts poor prognosis and promotes migration of colon cancer cells <i>in vitro</i>]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoWang L +8 more
europepmc +1 more source
[High expression of ELFN1 is a prognostic biomarker and promotes proliferation and metastasis of colorectal cancer cells]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoWang K, Li H, Yu J, Meng Y, Zhang H.
europepmc +1 more source
[METTL27 is a prognostic biomarker of colon cancer and associated with immune invasion]. [PDF]
Nan Fang Yi Ke Da Xue Xue Bao, 2022 Wang K, Zhang J, Deng M, Ju Y, Ouyang M.
europepmc +1 more source
运用蛋白质组学技术研究结肠粘膜、腺瘤及腺癌组织蛋白的差异表达
, 2008 ［目的］通过比较结肠正常粘膜、腺瘤、腺癌组织之间的蛋白质组表达差异，寻找结肠腺癌相关的蛋白质，筛选结肠癌早期诊断的分子标志物。［方法］运用比较蛋白质组学技术，对8例结肠癌患者（伴有腺瘤）的正常粘膜、腺瘤、腺癌组织提取的总蛋白进行双向电泳（2-D），分析凝胶图片选择两两间差异表达超过2倍的蛋白质进行MALDI-TOF/TOF质谱分析和生物学信息分析。［结果］成功建立结肠正常粘膜、腺瘤、腺癌的双向凝胶电泳图谱，在凝胶电泳图谱中平均蛋白质斑点数分别为3066 、2986和3289 ...
core
[Perioperative Neurocognitive Disorders in Patients With Colorectal Cancer Undergoing General Anesthesia: Influencing Factors and Development of a Nomogram Prediction Model]. [PDF]
Sichuan Da Xue Xue Bao Yi Xue BanTao W, Xia X, Dai Z, Li R.
europepmc +1 more source
[Application of three-dimensional visualization technique in laparoscopic D3 radical resection of right colon cancer]. [PDF]
Nan Fang Yi Ke Da Xue Xue Bao, 2022 Chen J +7 more
europepmc +1 more source
, 2016 摘要： 【目的】 观察结直肠癌患者亚甲基四氢叶酸还原酶（ＭＴＨＦＲ）基因Ｃ６７７Ｔ和Ａ１２９８Ｃ多态性与化疗后无进展生存期的相关性。【方法】 收集经病理学确诊的Ⅳ期结直肠腺癌患者共８１例，接受标准的ＦＯＬＦＯＸ６方案或ＸＥＬＯＸ方案化疗，化疗前抽取患者外周血，采用ＤＮＡ测序的方法检测ＭＴＨＦＲ基因Ｃ６７７Ｔ和Ａ１２９８Ｃ多态性，比较不同基因型化疗后的无进展生存时间，并分析各种因素和预后的相关性。【结果】 ８１例结直肠癌患者中，ＭＴＨＦＲ６７７ ＣＣ、ＣＴ、ＴＴ基因型分别为：５４．３％、４１．９％、３．７％
core
[Selenocystine inhibits colon cancer cell growth by promoting reactive oxygen species generation to trigger oxidative damage]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoSong Q +8 more
europepmc +1 more source
[Association Between the Protein Expressions of MutS Homologs and Villin and the Clinicopathological Characteristics in 310 Colon Cancer Patients]. [PDF]
Sichuan Da Xue Xue Bao Yi Xue BanChang F +7 more
europepmc +1 more source