Results 81 to 90 of about 7,856 (126)

[Mechanisms and clinical research progress of mesenchymal stromal cell therapy for steroid-refractory acute graft-versus-host disease]. [PDF]

Zhonghua Xue Ye Xue Za Zhi
Wang N, Xu ZL, Liu DH.
europepmc   +1 more source

免疫检查点抑制剂耐药机制研究进展

Zhongshan Daxue xuebao. Yixue kexue ban
免疫检查点抑制剂（ICIs）通过解除对免疫系统的抑制性调控机制，恢复并增强机体的抗肿瘤免疫应答，为肿瘤治疗带来里程碑式飞跃，彻底改变了多种恶性肿瘤的治疗模式，使部分患者的生存期显著延长。然而，临床实践中发现多数患者对ICIs治疗产生原发性耐药（初始治疗无应答）或获得性耐药（疾病得到控制后出现的耐药），极大地限制了其在临床上的广泛应用。ICIs耐药表型的产生可能源于不同的生物学机制，耐药机制复杂，涉及肿瘤细胞自身特性改变、肿瘤微环境重塑以及机体免疫系统状态等多个层面。深入探究ICIs耐药机制 ...
杨彩波, 符立梧
doaj  

[<i>Shengmai San</i> improves osimertinib resistance of non-small cell lung cancer cells by regulating the lactate/Wnt/β-catenin/LDHA pathway]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Liang Z, Pan F, Deng L, Mai Z, Ma Y, Shi C, Fu W.   +6 more
europepmc   +1 more source

[Overexpression of lncRNA SNHG12 promotes docetaxel resistance of prostate cancer cells by activating PI3K/AKT signaling <i>via</i> interacting with ELAVL1]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Zhao C, Li W, Zheng B, Wang G, Xiao Z, Li Y.   +5 more
europepmc   +1 more source

[Antitumor component-Ι in <i>Agkistrodon halys</i> venom inhibits proliferation and migration of cisplatin-resistant gastric cancer cells by downregulating RAI14]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Li Y, Li CDC, Guo R, Han H, Lu L, Zhou F, Zhi H, 支 慧.   +7 more
europepmc   +1 more source

[Identification of SORD as A Key Gene Mediating Osimertinib Primary Resistance 
in EGFR-Mutant Lung Adenocarcinoma via Machine Learning and Methylomics]. [PDF]

Zhongguo Fei Ai Za Zhi
Liang G, Wu H, Jia C, Gao P, Zhang Z, Chen C, Li Y, Liu H, Chen J.   +8 more
europepmc   +1 more source

[Role and Mechanism of Hyaluronic Acid-modified Milk Exosomes 
in Reversing Pemetrexed Resistance in Lung Adenocarcinoma Cells]. [PDF]

Zhongguo Fei Ai Za Zhi
Wu L, Lei J, Li H.
europepmc   +1 more source

[Advances in Antibody-drug Conjugates for Non-small Cell Lung Cancer 
after Resistance to First-line Therapy]. [PDF]

Zhongguo Fei Ai Za Zhi
Li H, Jing Y, Sun J, Xu J, Li Y.
europepmc   +1 more source

[Establishment and Evaluation of a Nucleic Acid Amplification Test for Spectinomycin-Resistant <i>Neisseria gonorrhoeae</i>]. [PDF]

Sichuan Da Xue Xue Bao Yi Xue Ban
Yang G, Li M, Wang Y, Yong G, Wang H, Bie M.   +5 more
europepmc   +1 more source

[Carbapenemase Genes, Virulence Genes, and Molecular Epidemiology of Carbapenem-Resistant Klebsiella pneumoniae Derived From Bloodstream Infections]. [PDF]

Sichuan Da Xue Xue Bao Yi Xue Ban
Liao Q, Yuan Y, Zhang W, Deng J, Kang M.
europepmc   +1 more source