Results 21 to 30 of about 26,044 (185)
基于暴露组-脂质组关联研究的代谢相关脂肪性肝病血清中外源性化学物质的风险分析
Se pu = Chinese journal of chromatography代谢相关脂肪性肝病是当前常见的一种肝脏疾病,在世界范围内的患病率高达25%,严重危害人类健康并对社会造成巨大的经济负担。越来越多的研究表明慢性非传染性疾病的发生是环境暴露与遗传因素共同作用的结果,环境污染是其不可小觑的健康风险因素。为了探究环境暴露对代谢相关脂肪性肝病风险及暴露效应,本研究利用超高效液相色谱-串联质谱(UHPLC-MS/MS)的靶向暴露组学和超高效液相色谱-高分辨质谱(UHPLC-HRMS ...
Qianqiang Chen +6 more
semanticscholar +1 more source
The effects of Tao-Hong-Si-Wu on hepatic necroinflammatory activity and fibrosis in murine model of chronic liver disease [PDF]
, 2016 背景：桃红四物汤原名加味四物汤，载于《医垒元戎》，录自《玉机微义》，是在四物汤的基础上加桃仁、红花而成，是活血养血之代表方。桃红四物汤在临床上应用广泛，诸多研究表明桃红四物汤对多种慢性肝病有一定的治疗作用。慢性肝损伤伴肝纤维化发展过程中存在明显的病理性血管生成与重构，阻碍了肝纤维化的逆转与恢复。通过桃红四物汤对病理性血管生成作用的研究，发现部分活血化瘀中药具有抑制病理性血管生成的作用，抗病理性血管生成可能是活血化瘀药的现代药理作用之一 ...
史萌萌
core
乙肝病毒cccDNA的研究现状 The Research Status of Hepatitis B Virus cccDNA
, 2015 乙型肝炎病毒(HBV)是一种小DNA病毒，共价闭合环状DNA (cccDNA)是HBV的原始复制模板，对乙肝病毒的复制及感染状态的建立具有重要意义。本文旨在对近年来有关cccDNA的形成、常用检测方法、抗病毒药物对其的影响等方面的进展作一综述报道。 The hepatitis B virus (HBV) is a kind of small DNA virus. The original template of covalently closed circular DNA (cccDNA) HBV is
王宁
semanticscholar +1 more source
Animal Models and Experimental Medicine, Volume 8, Issue 8, Page 1387-1399, August 2025.Post‐stroke depression (PSD) animal model of traditional Chinese medicine (TCM) combined with disease and syndrome often uses western medicine surgery (including: middle cerebral artery embolization to construct cerebral ischemia, or brain injection of collagenase to construct cerebral hemorrhage) combined with other methods (including: isolation ...
Jielin Wang +4 more
wiley +1 more source
Research on the Mechanism of using Geniposide to improve the Free Fatty Acid Metabolism of Rats with Non-alcoholic Fatty Liver Disease [PDF]
, 2015 目的： 1.观察栀子苷改善非酒精性脂肪性肝病的效果； 2.从游离脂肪酸探讨栀子苷调节非酒精性脂肪性肝病的作用机制。 方法： 实验分两部分进行。 1.栀子苷改善大鼠非酒精性脂肪性肝病的药效学实验：将40只雄性大鼠随机分为正常组和造模组，分别给予普通饲料和改良后的高脂饲料喂养，4周后将造模组再随机分为模型组、栀子苷组及血脂康组，并给这4组老鼠分别灌胃给药或蒸馏水。观察一般情况，留取标本后记录并计算相应数据（体重、肝湿重、脂肪重），用相应方法检测肝组织TG、FFA，血清CHO、LDL-C、HDL-C的含量 ...
林曼婷
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Combating infections under siege: Healthcare challenges amidst the military assault in Gaza
World Medical &Health Policy, Volume 17, Issue 1, Page 188-213, March 2025.Abstract The ongoing Israeli military assault on Gaza has caused a devastating collapse of healthcare infrastructure, resulting in an unprecedented surge in infectious diseases. The destruction of sanitation systems, restrictions on medical supplies, and displacement of civilians have created an environment conducive to the rapid spread of waterborne ...
Bilal Irfan +24 more
wiley +1 more source
Optimazation Dosage Study of the Combination of Chlorogenic and Geniposide on Non-alcoholic Fatty Liver Disease [PDF]
, 2015 目的：本研究通过运用数学模型均匀设计法，观察中药有效成分绿原酸、栀子苷配伍使用对高脂饮食诱导非酒精性脂肪性肝病（NAFLD）大鼠模型所产生的药理效应。并从多角度指标分析绿原酸、栀子苷对NAFLD脂质代谢紊乱、肝脏炎症损伤病理状态的影响，筛选出绿原酸-栀子苷组合抗NAFLD的最优剂量配比，探索中药复方治疗NAFLD的药效基础。 方法：1、均匀设计筛选实验：55只雄性Wistar大鼠，随机分为正常组、造模组。正常组普通饲料喂养，造模组采用改良高脂饲料饮食8周诱导NAFLD大鼠模型 ...
赵逍
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Evidence-Based Complementary and Alternative Medicine, Volume 2019, Issue 1, 2019., 2019 A survey study was conducted in Korean medicine doctors who provide nonsurgical integrative treatment for cervical disc herniation (CDH) at spine‐specialty hospitals to assess usual treatment practices, diagnosis and treatment methods, and related adverse events for CDH.
Hee Seung Choi +7 more
wiley +1 more source
The role of C-terminal region of Hepatitis B virus x protein on virus replication and cell death [PDF]
, 2016 在全球范围内，肝细胞癌（HCC）是临床上最常见的恶性肿瘤之一。乙型肝炎病毒（HBV）的持续感染是引起HCC的高危因素。乙型肝炎病毒（HBV）X蛋白（HBx）对于HBV的复制和HBV相关肝癌的发生发展起着重要的作用。本研究从HBV相关肝癌患者的癌、癌旁组织标本和血清标本出发，发现HBV相关肝癌组织的低复制性与HBx羧基端的截短突变有相关性。先前也有研究表明HBx羧基端截短突变体对于HBV的复制水平又不同程度的影响，但是所涉及的亚细胞结构靶点及参与的作用机制尚未阐明 ...
林碧芸
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