慢性阻塞性肺疾病合并肺炎链球菌肺炎患者BCL-2表达水平及对肺功能的影响研究
Zhongguo shiyan zhenduanxue, 2019 慢性阻塞性肺疾病(COPD)能够增加患者终末期肺功能衰竭的发生风险,流行病学研究显示,COPD的发病率可达233-455/10万人左右[1,2],特别是在长期吸烟或者具有肺气肿等疾病的人群中,COPD的发病率可进一步上升。细胞凋亡或者增殖平衡的紊乱,是促进血管内皮细胞、平滑肌细胞损伤,并诱导下游炎症反应富集的重要因素。抗凋亡因子BCL-2的表达,能够通过平衡BAX蛋白的表达,拮抗凋亡蛋白的表达,抑制细胞的凋亡,减轻支气管内皮细胞的损伤,保护支气管内皮的完整性,进而保护内皮下组织,降低肺气肿的发生风险 ...
侯晓俊 +4 more
doaj
[Hydroxysafflor yellow A attenuates heat stroke-induced acute lung injury in mice by inhibiting necroptosis]. [PDF]
Nan Fang Yi Ke Da Xue Xue Bao, 2022 Liu X +9 more
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鼠肝缺血再灌注后肺组织ERK1/2通路活性变化及褪黑素的影响
Zhongguo shiyan zhenduanxue, 2011 目的探讨大鼠全肝缺血再灌注后肺组织损伤、修复过程中ERK1/2信号通路活性的动态变化与意义,以及褪黑素对该信号通路的影响。方法本实验将分成两部分完成。第一部分,36只SD大鼠随机分成6组（n=6）:①缺血前组;②再灌注0.5 h组;③再灌注3 h组;④再灌注6 h组;⑤再灌注12 h组;⑥再灌注24 h组。阻断肝门30 min后开放血流,建立大鼠全肝缺血再灌注模型。分别于缺血前5 min、再灌注0.5 h、3 h、6 h、12 h、24 h处死动物取肺,检测ERK1/2和p-ERK1/2表达、细胞凋亡 ...
姜春玲 +4 more
doaj
Mechanism of chlorogenic acid reducing lipopolysaccharide-induced acute lung injury in mice by regulating miR-223/NLRP3 axis. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2022 Liu C, Cheng X, Sun J, Zhang S, Zhang Q.
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Clinical report of 11 cases of inhalation poisoning caused by mixed gases of hydrogen sulfide and hydrogen cyanide [PDF]
, 2023 WANG Jian, ZHANG Jinsong
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Zhongguo shiyan zhenduanxue, 2016 有研究表明术后心、肺、脑、肾等重要脏器的并发症是肺癌和食管癌导致患者围手术期死亡的主要因素[1]。因此,如何改善老年患者术后生存质量和长期预后具有积极意义。阿司匹林是非甾体抗炎镇痛药,具有强效抗血小板聚集作用,已广泛用于心脑血管疾病的一、二级预防和治疗。对于为预防血栓形成性心脑血管事件而服用阿司匹林的患者,推荐至少在术前7天内停用阿司匹林。有研究发现阿司匹林对急性肺损伤[2 ...
徐学敏 +4 more
doaj
[Research advances on the mechanisms and prevention and treatment of patient self-inflicted lung injury]. [PDF]
Zhonghua Shao Shang Za Zhi, 2021 Ren ZG, Zhu F.
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Zhongguo shiyan zhenduanxue, 2013 急性胰腺炎（acute pancreatitis,AP）是胰酶引起的一种化学炎症反应性疾病,其出血坏死型（a-cute necrotizing pancreatitis,ANP）病情凶险,预后差,病死率高达50%左右。急性胰腺炎相关性肺损伤（acute pancreatitis-associated lung injury,APA-LI）是AP最常见的并发症,是患者早期死亡的重要原因.炎症介质的互相激活和级联反应是APALI的重要发生机制之一。多种炎性因子参与了急性胰腺炎肺损伤的发生,如IL-6,TNF-
蒋海弦 +4 more
doaj
[Activation of cannabinoid receptor 2 alleviates acute lung injury in rats with lipopolysaccharide-induced sepsis]. [PDF]
Nan Fang Yi Ke Da Xue Xue Bao, 2022 Kang H, Jiang S, Song Q, Zhang Y.
europepmc +1 more source
Treatment experience of six cases with acute poisoning caused by inhalation of chlorine dioxide [PDF]
, 2023 LAO Jiazhi
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