Results 71 to 80 of about 4,954 (149)
LPS诱导的肺纤维细胞PTEN基因表达和Akt磷酸化蛋白表达的研究 [PDF]
Objective: To investigate PTEN gene expression and the Akt phosphorylation of protein expression in the LPS-induced lung fibroblast, to initially reveal the relation between PTEN gene and the Akt phosphorylated proteins to LPS-induced lung fibroblast ...
Cui, Ning +3 more
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Zhongshan Daxue xuebao. Yixue kexue ban, 2017 【目的】通过构建小鼠急性肺损伤（ALI）模型，示踪间充质干细胞（MSC）治疗急性肺损伤。【方法】以MSC表面 神经节苷脂（GD2）特异性抗原靶向的单克隆抗体Anti?GD2为载体，与荧光菁染料（Cy7）共价结合，得到新型荧光分子探针 Anti?GD2?Cy7。将合成的荧光分子探针Anti?GD2?Cy7通过抗原抗体反应标记在MSC上。本研究取84只Balb/c雄性小鼠，随 机抽取其中 48只平均分成三组：假手术组（n = 16）、MSC+ALI组（n = 16）和NS+ALI组（n = 16 ...
刘耕龙 +6 more
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[Sevoflurane alleviates ventilator-induced lung injury in rats by down-regulating the TRPV4/C-PLA2 signaling pathway]. [PDF]
Nan Fang Yi Ke Da Xue Xue Bao, 2023 Wang W +7 more
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Correlation of serum activated protein C and 4⁃hydroxynonenal levels with myocardial injury in severe pneumonia and their prognostic prediction [PDF]
Objective To investigate the changes of serum activated protein C（APC）and 4 ⁃ hydroxynonenal（4 ⁃ HNE）levels in patients with severe pneumonia，and analyze their correlation with patient outcomes and myocardial injury.
GAO Tian*，WANG Wei，WANG Ling，QIAN li，HAN fei，WANG Shuo，YE Xiaoman，YIN Jie，ZHAI Aiqin
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Zhongguo shiyan zhenduanxue, 2018 Jagged1(JAG1)可以调节诸多细胞表型,并在辐射诱导的肺纤维化过程中发挥重要作用,在肺损伤发展过程中,血管周围成纤维细胞中的Notch被激活,激活的Notch可与JAG1结合,并抑制肺组织正常的损伤修复过程,从而促进肺纤维化的发生发展。放射性肺纤维化是放射治疗最为棘手的并发症之一。如何减少放射性肺纤维化的发生、减轻肺纤维化程度,以增强放疗的效果已经成为肿瘤放射治疗的一个热点。了解掌握JAG1在肺纤维化发生、发展中的分子机制,对防治肺纤维化,减少并发症的发生具有重要意义 ...
来志扬, 魏仲航
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Zhongguo shiyan zhenduanxue, 2021 抗中性粒细胞胞浆抗体（ANCA）相关性血管炎（AAV）是一种自身免疫性疾病,可累及多系统及器官,其中以肾脏及肺脏受累最为多见,肾脏受累率高达60%[1]。肾脏受累主要表现为血尿、蛋白尿、水肿、血压升高、肾脏功能进行性恶化等。不及时确诊及治疗,可快速发展至终末期肾病（ESRD）,严重降低患者的生活质量。有研究表明,AAV肾损伤5年发展至ESRD可高达27%[2]。目前对AAV肾损伤的发病机制、治疗及预后研究较多,而对AAV肾损伤的病理特点研究较少。
王淑平 +3 more
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[Knockout of S1PR3 attenuates acute lung injury in mice by inhibiting the MAPK pathway]. [PDF]
Nan Fang Yi Ke Da Xue Xue Bao, 2022 Fang S, Yuan R, Sun R, Ma T.
europepmc +1 more source
Zhongguo shiyan zhenduanxue, 2007 目的探讨核因子-κB（NF-κB）在急性坏死性胰腺炎大鼠肺损伤发病中的作用。方法制作大鼠急性坏死性胰腺炎（ANP）模型,随机分为正常对照组、急性坏死性胰腺炎组。应用原位杂交法检测肺组织NF-κB p65mRNA的表达。结果ANP组肺组织病理改变明显;NF-κB p65mRNA在ANP时除肺泡的细胞质内有表达外,出现细胞核内表达,随时间的延长表达逐渐增加。结论NF-κB活化是急性坏死性胰腺炎早期细胞内重要事件,NF-κB与ANP的肺损伤密切相关。
崔勇, 龙泽民, 刘任飞, 刘瑾琨
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Zhongshan Daxue xuebao. Yixue kexue ban, 2013 【目的】 探讨紫杉醇诱发大鼠肺损伤的机制及帕瑞昔布钠的干预作用?【方法】 实验大鼠随机分为4组:空白对照组(Con组),紫杉醇化疗组(Pac组),帕瑞昔布钠干预组(Pac + Pare组),帕瑞昔布钠组(Pare组)?观察肺泡换气功能?肺泡-毛细血管膜通透性及肺组织病理的改变,检测肺组织炎性因子?环氧化酶2(COX-2)含量及紧密连接蛋白(ZO-1及Claudin-4蛋白)的表达?【结果】 与Con组比较,Pac组大鼠肺组织COX-2表达显著升高(P < 0.01),肺组织炎性改变明显;ZO ...
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The application of chest wall compression in ventilation of acute respiratory distress syndrome patients [PDF]
Acute respiratory distress syndrome (ARDS) is a life-threatening non-cardiogenic pulmonary edema. Despite lung-protective ventilation strategies serving as the cornerstone of ARDS treatment, some patients still fail to effectively alleviate hypoxemia or ...
LIU Xiaoqing +3 more
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