Results 61 to 70 of about 4,954 (149)
Exploring the mechanism of matrine on lung inflammation in mice infected with respiratory syncytial virus by regulating PI3K/AKT signaling pathway [PDF]
Objective To explore the protective mechanism of matrine against respiratory syncytial virus (RSV) infection in mice based on the PI3K/AKT signaling pathway.
DU Mingwei +8 more
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Zhongshan Daxue xuebao. Yixue kexue ban, 2011 【目的】观察姜黄素对兔单肺通气导致的肺损伤的影响。【方法】12只新西兰白兔随机分为单肺通气组(组Ⅰ)和单肺通气+姜黄素组（组Ⅱ），每组6只。于实验前七天开始灌胃给药，组Ⅰ给予对照剂，组Ⅱ给予姜黄素40mg/kg，每天早晚各一次。两组动物均气管切开插入单腔气管导管（ID:3.5mm）建立右侧单肺通气模型，采用容量通气模式（潮气量 12 mL/kg，呼吸频率40 min-1，I:E=1：2）并模拟左侧开胸手术。先双肺通气30min，再单肺通气3h，恢复双肺通气30min。监测两组兔血气及气道峰压 ...
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Zhongshan Daxue xuebao. Yixue kexue ban, 2013 【目的】: 观察骨髓间充质干细胞(MSC)对新生大鼠高氧肺损伤的治疗作用?【方法】 贴壁法体外培养扩增大鼠骨髓MSC,利用携带GFP基因的慢病毒液对骨髓MSC进行转染;SD新生大鼠随机分为A?B?C?D?E五组,A,B两组高氧暴露7 d后经尾静脉分别注射(1 × 105 /只和1 × 104 /只)骨髓MSC,C组注射磷酸盐缓冲液(PBS),D?E两组为空气组,分别注射骨髓MSC和PBS,观察骨髓MSC在大鼠肺组织的分布情况?大鼠的体质量增长?肺系数?放射性肺泡计数(RAC)及肺组织的病理改变?【结果】
张红珊
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Protective effect of glycyrrhizic acid monosaccharide on acute lung injury caused by single-walled carbon nanotubes in mice [PDF]
, 2023 ZHANG Jing, ZHANG Xiaoli
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Emerging treatment strategies for pulmonary fibrosis in precision medicine [PDF]
Pulmonary fibrosis （PF） is a chronic progressive lung disease that poses a serious health risk. It is mainly characterized by abnormal fibrosis and scarring of lung tissues， resulting in the gradual replacement of alveoli with fibrous tissues and ...
XIA Dong, YANG Huiling
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Zhongshan Daxue xuebao. Yixue kexue ban, 2017 【目的】探讨程序性坏死是否参与肠缺血再灌注所致肺损伤的发病机制。【方法】雄性SD大鼠32只，随机分 为4组（n = 8）：假手术组（sham组）、肠缺血再灌注组（I/R组）、程序性坏死特异性抑制剂Necrostatin?1组（Nec-1组）和溶剂二 甲基亚砜组（DMSO组）。采用夹闭肠系膜上动脉1.5 h再灌注6 h的方法制备肠缺血再灌注损伤模型。sham组仅分离血管； Nec-1组及DMSO组分别于夹闭肠系膜上动脉前30 min时腹腔注射Necrostatin?11.0 mg ...
温仕宏, 刘克玄
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Zhongguo shiyan zhenduanxue, 2022 转移性钙化(metastatic calcification,MC)是由于全身性的钙、磷代谢障碍,引起机体血钙或血磷升高,导致钙盐在未受损伤的组织内沉积,随血液循环异位于肾小管、肺泡壁等软组织或血管壁。转移性肺钙化(metastatic pulmonary calcification,MPC)是钙在肺组织中沉积,继发于无肺软组织损伤史的钙代谢异常。最常见的原因为慢性肾功能衰竭,血液透析,器官移植术后,原发性或继发性甲状旁腺功能亢进症,破坏性骨损害等[1-5]。发病率低,国内外报道以个案病例为主 ...
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[Research Progress on the Protective Effect of Intestinal Flora on Radiation-induced Lung Injury in Thoracic Tumors]. [PDF]
Zhongguo Fei Ai Za Zhi, 2023 Liu G, E M.
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Zhongguo shiyan zhenduanxue, 2018 目的研究肺泡上皮钠离子通道3种亚型在不同急性肺损伤模型中的差异表达。方法雄性SD大鼠40只随机分为对照组(Control组,n=10)和3种急性肺损伤模型:脂多糖诱导组(LPS组,n=10)、盐酸诱导组(HCL组,n=10)、机械通气组(VILI组,n=10)。分别检测各组支气管肺泡灌洗液蛋白浓度和白细胞计数、钠离子通道(ENaC)三种亚型(α、β、γ)mRNA的表达和蛋白的表达。结果支气管肺泡灌洗液蛋白浓度和白细胞计数LPS组、HCL组、VILI组,均明显高于Control组,差异有统计学意义(P0 ...
张俊志 +5 more
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Protective effect of adrenomedullin on hyperoxia-induced lung injury. [PDF]
Zhongguo Dang Dai Er Ke Za Zhi, 2021 Zhang M, Cheng LH, Yin XT, Luo H, Cai C.
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