[Analysis of the Correlation between Immune Cell Subsets in Bronchoalveolar Lavage Fluid and the Efficacy of First-line Use of Immunotherapy in Advanced Non-small Cell Lung Cancer: A Case-control Study]. [PDF]
Zhongguo Fei Ai Za Zhi背景与目的 免疫治疗已成为晚期非小细胞肺癌（non-small cell lung cancer, NSCLC）患者的标准治疗，但对于接受免疫治疗的晚期NSCLC患者仍缺乏特异性的疗效预测生物标志物，本研究通过探索支气管肺泡灌洗液（bronchoalveolar lavage fluid, BALF）中淋巴细胞亚群情况，并结合NSCLC患者的临床和实验室检查指标，探索潜在的免疫治疗相关性生物标志物。 方法 ...
Zhang K +5 more
europepmc +2 more sources
[Application of bronchoalveolar lavage fluid in patients with pulmonary complications after allogeneic hematopoietic stem cell transplantation]. [PDF]
Zhonghua Xue Ye Xue Za Zhi, 2019 目的 评估支气管肺泡灌洗术（BAL）在异基因造血干细胞移植（allo-HSCT）患者肺部并发症中的诊断价值及安全性。 方法 采用BAL获取肺泡灌洗液（BALF）进行微生物涂片/培养、巨细胞病毒/EB病毒及结核分枝杆菌DNA检测、宏基因组新一代测序对allo-HSCT后肺部并发症进行病因学分析。 结果 纳入73例allo-HSCT患者，男47例，女26例，中位年龄41（15~64）岁。共发生86例次肺部并发症事件，进行132例次BAL。BALF检测病因学诊断率为88.4%（76/86 ...
Li S +9 more
europepmc +2 more sources
2 型固有淋巴细胞主导的小鼠呼吸道变应性炎症模型的建立 [PDF]
Zhongshan Daxue xuebao. Yixue kexue ban, 2019 【目的】应用野生型C57BL/6小鼠和T/B细胞缺陷的Rag1-/-小鼠建立以2型固有淋巴细胞（ILC2）为主导的小鼠呼吸道变应性炎症模型。【方法】分别将雌性C57BL/6小鼠和Rag1-/-小鼠随机平均分为对照组和实验组，并分别于第1、3、5天经气道滴注给予20μLddH2O或含1μgIL-33的ddH2O。第6天处死小鼠后收集肺泡灌洗液和肺组织，通过病理染色及流式检测炎症细胞浸润，通过酶联免疫吸附实验检测细胞因子水平及应用流式检测ILC2水平。【结果】C57BL/6和Rag1 ...
孟祥慈
doaj +2 more sources
Goodpasture syndrome complicated with lung infection: a case report and literature review [PDF]
, 2023 Objective To investigate the clinical characteristics， diagnosis and treatment of Goodpasture syndrome complicated with lung infection. Methods Clinical data of one case of Goodpasture syndrome complicated with pulmonary infection were retrospectively ...
Cen Tiantian, Zhang Xiaoqun, Ma Hongying
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Structure of an Acidic Polysaccharide from Brassica rapa L. and Its Protective Effect on Lipopolysaccharide-Induced Lung Injury in Mice [PDF]
, 2023 Objective: To study the structure of BRAP-1, an acidic polysaccharide from Brassica rapa L. and its effect and mechanism on lipopolysaccharide (LPS)-induced lung injury in mice.
Kadierya·KUERBAN, Ajiranmu·Abula, CHEN Zhuo’er, Miherenisha·AMUREJIANG, Hailiqian·TAOERDAHONG, YANG Fei
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Macrophage differential genes and their functions in silicosis based on single cell RNA sequencing and spatial transcriptome sequencing [PDF]
, 2022 BackgroundThe rise of single cell RNA sequencing (scRNA-seq) and spatial transcriptome sequencing technologies has allowed for intensive study of lung diseases, but both have been poorly studied in silicosis.
Jie CHAO, Wei ZHANG, Xinbei ZHOU
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Research progress on the relationship between lung microbiome and lung cancer [PDF]
, 2023 Lung cancer is the leading cause of cancer-related deaths worldwide. Lung microbiome is defined as the microbial organisms located in the lung. With rapid development of next-generation sequencing， microbiome has been found to affect the host’s nutrition，
Ge Yijun, Cao Chao
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The Study of the Value of High Mobility Group Protein B1 Combined with Acute Physiological Score in the Diagnosis and Prognosis of Children with Severe Pneumonia [PDF]
, 2022 BackgroundSevere pneumonia in children is a common respiratory critical illness, and accurate assessment of its prognosis is the key to reasonable clinical decision-making. High mobility group protein B1 (HMGB1) and acute physiology score (APS) have high
KANG Ping, LI Yi, TANG Yu
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Review of CD4+ T cell subsets in asthma phenotypes: molecular mechanisms and biologic treatment options [PDF]
, 2023 Asthma is a chronic inflammatory airway disease, mainly driven by different CD4+ T cell subsets [helper T cell (Th cell)]. CD4+ T cell subsets are a type of important immune cells, capable of secreting various cytokines, and regulating the immune ...
WANG Chuanping, ZHAO Yanhong
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Research progress of immune response regulated by epigenetic modification in pneumonia [PDF]
, 2023 Pneumonia is one of the most common infectious diseases, and although considerable progress has been made in the diagnosis and treatment of pneumonia, it is still associated with high mortality, prolonged hospitalization, and significant medical ...
HAN Xiao, WANG Qing, ZHANG Xiaobo
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