Identification of Candidate Plasma Altered miRNA Associated with Bone Metastasis of Lung Cancer [PDF]
目的:应用高通量miRNA芯片及荧光定量PCR技术筛选及鉴定肺癌骨转移血浆中差异表达的miRNA。 方法:搜集2013至2015年在厦门大学附属第一医院入院的45例肺癌病人外周血标本。选取4例肺癌骨转移与4例肺癌无骨转移病人血浆,应用miRNA芯片技术对差异表达的miRNA进行筛选。应用IPA分析差异miRNA参入的信号通路。应用Real-timePCR检测候选差异表达miRNA,进行验证。 结果:通过比对,成功建立了肺癌骨转移与肺癌无骨转移血浆miRNA芯片表达谱,筛选出了12个差异表达miRNA ...
王文一
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Implications of Tobacco Use on Pathogen‐Driven Diseases: A Public Health and Policy Perspective
ABSTRACT The tobacco epidemic remains one of the most significant global public health challenges, responsible for over 8 million deaths annually, with a substantial portion occurring among non‐smokers exposed to second‐hand smoke. While cigarette smoking remains the most prevalent form of tobacco use worldwide, the rise of electronic nicotine delivery
Nadine Kabbani, James L. Olds
wiley +1 more source
The expression of USP39 in non-small cell lung cancer and its function in A549 cells [PDF]
肺癌是最常见的肺部原发性恶性肿瘤,由于其中大部分起源于支气管粘膜上皮,所以又称支气管肺癌。其中非小细胞肺癌(non-smallcelllungcancer,NSCLC)占到85%。如今肺癌已成为全世界范围内癌症死亡的首要原因,其患病率和死亡率均居各大恶性肿瘤之首。在中国,随着人口基数的快速增长以及环境污染的恶化,肺癌的死亡率在急剧上升。可见,肺癌已经成为全人类健康的重要威胁。虽然近年来各种化疗药物和手术治疗的联合应用,在一定程度上提高了治疗效果,但是由于肺癌的发病隐匿,早期诊出率低 ...
袁家会
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The Role and Mechanism of Dihydroartemisinin in the Development of Non-Small Cell Lung Carcinoma [PDF]
背景及目的 肺癌是最常见的恶性肿瘤,在全世界范围内,也是肿瘤导致死亡的首位原因。非小细胞肺癌是肺癌最常见的一种类型。非小细胞肺癌细胞对凋亡的抵抗性是抗肿瘤治疗的一大主要的障碍。因此,目前研究关注的热点是那些能提高治疗抵抗非小细胞肺癌细胞凋亡的新型复合物的发展。双氢青蒿素是一种重要的青蒿素衍生物,是从中草药植物青蒿素中提取出来的天然产物。作为一种非常有效的抗疟疾药物,双氢青蒿素(DHA)在全世界范围内已经是治疗抗疟原虫的一线治疗药。近期研究发现DHA对乳腺癌,乳头瘤病毒导致的宫颈癌 ...
李春雷
core
Plasma microRNA Associated with EGFR-TKI Primary Resistance in Non-Small Cell Lung Cancer with EGFR-Mutation [PDF]
背景 肺癌是目前全世界范围内发病率和死亡率较高的恶性肿瘤之一。按组织学分类,肺癌可以分为两大类:小细胞肺癌(smallcelllungcancer,SCLC)和非小细胞肺癌(nonsmallcelllungcancer,NSCLC),小细胞肺癌占所有病例的20%,其余80%左右为NSCLC,包括鳞癌、腺癌、大细胞癌等类型。手术、放疗以及化疗等多学科综合治疗是指南推荐的NSCLC的首选治疗方式。由于NSCLC早期的典型临床症状和体征并不明显,约2/3的NSCLC患者在确诊时已发展为中晚期,失去手术根治机会。
潘小艳
core
Potential pitfalls of a fiducial marker matching technique carbon-ion radiotherapy for lung cancer [PDF]
学位記番号 ...
Shiba, Shintaro +2 more
core
The study of AKAP95 and Cx43 protein co-regulating cell G1/S phase transition [PDF]
本研究分为两部分,第一部分采用免疫组织化学实验,包括肺癌组织中AKAP95和CyclinD3、Akt蛋白表达与临床病理学指标的关系及3种蛋白之间的关联性分析、直肠癌组织中AKAP95、CyclinD1、CyclinE1和Cx43蛋白的关联性分析。通过检测51例肺癌组织和15例癌旁组织中细胞周期蛋白D3(CyclinD3)、蛋白激酶A锚定蛋白95(AKAP95)和丝/苏氨酸激酶(serine/threoninekinase,Akt,亦称蛋白激酶B,PKB)的表达发现,AKAP95 ...
原阳阳
core
Long-term Survival of Personalized Surgical Treatment of Locally Advanced Non-small Cell Lung Cancer Based on Molecular Staging [PDF]
Background and objective Approximately 35%-40% of patients with newly diagnosed non-small cell Lung cancer have locally advanced disease. The average survival time of these patients only have 6-8 months with chemotherapy.
Bin LIU +16 more
core
Detection of EGFR and COX-2 Expression by Immunohistochemical Method on a Tissue Microarray Section in Lung Cancer and Biological Significance [PDF]
Background and objective Epidermal growth factor receptor (EGFR) and cyclooxygenase-2 (COX-2), which can regulate growth, invasion and metastasis of tumor through relevant signaling pathway, have been detected in a variety of solid tumors.
Congzhong ZHU, Juan LIU, Xinyun WANG
core

