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Implications of Tobacco Use on Pathogen‐Driven Diseases: A Public Health and Policy Perspective
World Medical &Health Policy, Volume 17, Issue 3, Page 468-474, September 2025.ABSTRACT The tobacco epidemic remains one of the most significant global public health challenges, responsible for over 8 million deaths annually, with a substantial portion occurring among non‐smokers exposed to second‐hand smoke. While cigarette smoking remains the most prevalent form of tobacco use worldwide, the rise of electronic nicotine delivery
Nadine Kabbani, James L. Olds
wiley +1 more source
Zhongguo shiyan zhenduanxue, 1999 目的探讨Rb蛋白的表达状况与肺癌细胞分类的关系及肺癌细胞癌变的机制。方法采用Westernblotting方法，检测人类13种小细胞肺癌、9种非小细胞肺癌细胞株Rb蛋白的表达。结果和结论10种小细胞肺癌细胞株存在Rb蛋白的缺失或变异，而非小细胞肺癌细胞株则无此改变，对具有较宽Rb带纹的3种小细胞肺癌和9种非小细胞肺癌细胞株进行了Rb蛋白分型，发现2种小细胞肺癌和7种非小细胞肺癌细胞株以磷酸化型Rb蛋白为主。
赵美蓉 +7 more
doaj
Long-term Survival of Personalized Surgical Treatment of Locally Advanced Non-small Cell Lung Cancer Based on Molecular Staging [PDF]
, 2011 Background and objective Approximately 35%-40% of patients with newly diagnosed non-small cell Lung cancer have locally advanced disease. The average survival time of these patients only have 6-8 months with chemotherapy.
Bin LIU +16 more
core
Comparative Analysis of Clinical Epidemiology and Pathological Characteristics of 908 Patients with Primary Lung Cancer of Hunan Province in 1997 and 2007 [PDF]
, 2010 Background and objective Epidemiology of lung cancer will be changed along with time and region. The aim of this study is to acknowledge the tendency of primary lung cancer in hunan province in recent years by comparing and analyzing the distribution of ...
Chengping HU +4 more
core
Detection of EGFR and COX-2 Expression by Immunohistochemical Method on a Tissue Microarray Section in Lung Cancer and Biological Significance [PDF]
, 2010 Background and objective Epidermal growth factor receptor (EGFR) and cyclooxygenase-2 (COX-2), which can regulate growth, invasion and metastasis of tumor through relevant signaling pathway, have been detected in a variety of solid tumors.
Congzhong ZHU, Juan LIU, Xinyun WANG
core
Zhongguo shiyan zhenduanxue, 2012 目的检测氯通道ClC-2在人非小细胞肺癌中的表达情况,探讨ClC-2在非小细胞肺癌中表达的临床意义,为ClC-2成为临床肺癌治疗的新基因靶点提供新思路。方法实验分为对照组和肺良性病组、肺鳞癌组和肺腺癌组,应用半定量RT-PCR及Western blot方法检测各组ClC-2mRNA及ClC-2蛋白表达水平并对ClC-2在非小细胞肺癌中的表达情况进行初步分析。结果 ClC-2mRNA表达水平上与对照组相比,肺鳞癌组和肺腺癌组中的ClC-2mRNA表达量明显增多,但肺良性病与正常肺组织之间无显著差异 ...
许哲男 +4 more
doaj
hsa-miR-125a-5p Enhances Invasion Ability in Non-Small Lung Carcinoma Cell Lines [PDF]
, 2009 Background and objective MicroRNAs (miRNAs) are short non-coding RNAs that posttranscriptionally regulate gene expression by partially binding complementary to target sites in mRNAs.
Enhua WANG +4 more
core
Expression and Significance of gp96 and Immune-related Gene CTLA-4, CD8 in Lung Cancer Tissues [PDF]
, 2010 Background and objective It has been proven that gp96 plays an important role in specific cytotoxic immune response which is involved in anti-tumor effect in the body.
Haiyan ZHENG +4 more
core
Zhongguo shiyan zhenduanxue, 2012 目的探讨基因T-钙黏蛋白（CDH13）在40例癌组织,40例的癌旁组织标本和非肺癌良性肺切除组织标本15例作为对照的表达的临床意义,进一步研究其基因异常甲基化与肺癌的相关性。方法采用特异性甲基化PCR（MSP）检测该基因在肺癌组织中异常甲基化的水平。结果 1.在肺癌组织中CDH13基因甲基化率明显高于癌旁组织和非肺癌良性肺切除组织,甲基化率分别为32.5%、7.5%、6.7%,有统计学意义 ...
隋小芳, 王凤玲, 黄佳滨
doaj
Zhongguo shiyan zhenduanxue, 2017 肺癌（lung cancer,LC）包括非小细胞肺癌（non-small cell lung,NSCLC）和小细胞肺癌（SCLC）,其中非小细胞肺癌（鳞癌、腺癌和大细胞未分化癌）占肺癌的80%以上[1]。非小细胞肺癌按照TNM分期,临床上根据不同的病理分期采用相应的治疗方案 ...
刘一婷 +4 more
doaj