Results 11 to 20 of about 1,012 (110)

Expression and clinical significance of PLA2G2A in kidney renal papillary cell carcinoma [PDF]

open access: yes, 2023
Objective·To investigate the expression and clinical significance of phospholipase A2 Group ⅡA (PLA2G2A) in kidney renal papillary cell carcinoma (KIRP), and provide new ideas for seeking KIRP targets.Methods·The expression level of PLA2G2A in pan-cancer
LI Fang   +5 more
core   +1 more source

CXCL9 expression in breast cancer and its correlation with the characteristics of tumor immunoinfiltration [PDF]

open access: yes, 2023
Objective·To explore the effect of C-X-C motif chemokine ligand 9 (CXCL9) expression on the prognosis of breast cancer patients and its correlation with tumor-infiltrating immune cells (TIICs).Methods·Transcriptome data of 1 100 breast tumor tissues and ...
CAO Yuan   +6 more
core   +1 more source

Advances in the research, diagnosis and treatment of renal cell carcinoma in 2022 [PDF]

open access: yes, 2023
Renal cell carcinoma (RCC) is one of the three major urinary system tumors. With the changes of lifestyle and the rise of obesity, hypertension and other diseases, the incidence of RCC is increasing.
TIAN Xi, XU Wenhao, ZHU Shuxuan, AIHETAIMUJIANG•Anwaier, SU Jiaqi, YE Shiqi, QU Yuanyuan, SHI Guohai, ZHANG Hailiang, YE Dingwei
core   +1 more source

参与肾纤维化和肾透明细胞癌的关键基因

open access: yesLinchuang shenzangbing zazhi, 2023
徐启明, 路建饶
doaj   +1 more source

肾透明细胞癌患者术前血浆GAPDH cfNA水平对诊断及预后的价值

open access: yesZhongguo shiyan zhenduanxue, 2021
肾透明细胞癌(ccRCC)是最常见的肾恶性肿瘤[1],但由于缺乏特异性的生物标志物,目前临床上对于ccRCC预后的判断仍然依赖患者或肿瘤的临床和病理特征。寻找一种有效的生物标志物对于ccRCC患者的术后检测以及管理至关重要[2]。循环肿瘤细胞(CTCs)已经被证明在肾细胞癌患者的早期诊断和预后中具有潜在的应用价值[3-4]。
邱实, 陈坤, 衣琳, 于越海
doaj  

肾透明细胞癌超声造影参数与肿瘤新生血管相关性研究

open access: yesZhongguo shiyan zhenduanxue, 2021
肾细胞癌是最常见的肾脏恶性肿瘤,其中70%是肾透明细胞癌(ccRCC),ccRCC是最具有侵袭性的亚型[1]。肿瘤血管形成是多数人类肿瘤生长和转移的关键因素[2],ccRCC是高度血管化恶性肿瘤,微血管密度(MVD)和分化程度是预测病灶侵袭性的关键指标[3]。但由于现阶段缺乏无创性评价肿瘤新生血管MVD、分化程度的方法,
孟夏   +4 more
doaj  

基于数据挖掘分析PEG3基因在肾透明细胞癌中的表达及预后意义 [PDF]

open access: yes, 2018
目的:阐述印迹基因PEG3在肾细胞癌中的表达及意义。方法:利用Oncomine数据库及GEPIA分析PEG3在肾透明细胞癌组织中的表达情况;利用KM-Plotter做PEG3与肾透明细胞癌患者生存期的相关性分析,经Meth HC分析PEG3启动子区甲基化水平,String-DB数据库分析PEG3相互作用蛋白;通过The Human Protein Atlas分析PEG3蛋白在肾透明细胞癌中的蛋白表达情况。结果 :在mRNA水平上,PEG3在肾透明细胞癌中较正常肾组织显著低表达,表达水平与肾癌预后呈负相关(
崔强   +6 more
core  

载脂蛋白C1在肾透明细胞癌中表达及意义

open access: yesZhongguo shiyan zhenduanxue, 2023
目的 探讨载脂蛋白C1(apolipoprotein C1,APOC1)在肾透明细胞癌(clear cell renal cell carcinoma, CCRCC)中的表达情况,并分析其表达变化对CCRCC细胞生物学功能的影响,观察与预后的关系,并探讨其可能的机制。方法 对癌症基因组图谱(The Cancer Genome Atlas, TCGA)数据库中CCRCC的基因数据进行生物信息学分析,观察APOC1的表达情况及其与临床病理参数的关系,分析其表达与预后的关系。应用蛋白印迹(Western ...
张玉玺   +5 more
doaj  

肾透明细胞癌Caki-1细胞系差异表达基因的生物信息学分析 [PDF]

open access: yes, 2018
目的比较肾透明细胞癌Caki-1细胞系与正常肾上皮细胞系ASE-5063中的差异表达基因(DEGs),寻找潜在的肾透明细胞癌特异性分子标志物。方法利用GEO数据库自带的GEO2R在线分析工具分析基因芯片GSE78179,将筛选出的DEGs分别导入Metascape、STRING以及Cytoscape进行综合分析并筛选出核心基因。最后使用Fun Rich等软件对筛选出的核心基因进行GO和KEGG富集分析。结果共筛选出562个DEGs,其中上调基因345个,下调基因217个 ...
朱合欢   +5 more
core  

Mechanisms of PTEN-regulated PDK1 in modulating malignant phenotypes of clear cell renal cell carcinoma [PDF]

open access: yes
Background and purpose: The aberrant activation of pyruvate dehydrogenase kinase 1 (PDK1) drives tumor microenvironment remodeling and metastasis through mediating the Warburg effect.
DUAN Shuangshuang, GULINAIZAIER Abudusaimaiti, ZHANG Lijun, SUN Miao, LIU Huibin
core   +1 more source

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