Results 11 to 20 of about 2,641 (143)
Diabetes duration and weight loss are associated with onset age and remote metastasis of pancreatic cancer in patients with diabetes mellitus. [PDF]
J Diabetes, 2022 Highlights New‐onset diabetes and weight losses were common presentation and risk factors of early‐onset PC, which required more attention. Long‐term diabetes and heavy weight loss were risk factors contributing to distant metastases and less radical surgery, which needed to be better treated.
Ma M, Li W, Xu L, Ping F, Zhang H, Li Y.
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高表达的溶血卵磷脂酰基转移酶4促进胰腺癌细胞增殖的作用 [PDF]
Zhongshan Daxue xuebao. Yixue kexue ban目的探讨溶血卵磷脂酰基转移酶4（LPCAT4）在胰腺癌中的表达水平及其对胰腺癌细胞增殖的影响。方法在本研究中，利用在线数据库LinkedOmics在线分析KRAS突变型与野生型胰腺癌患者差异表达基因，使用阿拉巴马大学伯明翰分校癌症数据分析（UALCAN），桑格生信分析平台（Sangerbox 3.0）和表达谱交互分析2（GEPIA2）分析LPCAT4在胰腺癌组织中的表达情况。使用Kaplan-Meier Plotter数据库探究LPCAT4与胰腺癌患者预后的相关性 ...
卢灏铭 +7 more
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Journal of Diabetes, Volume 13, Issue 12, Page 1007-1014, December 2021., 2021 Highlights This prospective study compares 15 patients with immune‐checkpoint induced diabetes mellitus (CPI‐DM) with a propensity score matched cohort of patients with other diabetes types. Diabetic ketoacidosis at onset and autoimmune comorbidity is more frequent in CPI‐DM patients. This can be avoided by regular glucose measurements and education on
Sascha R. Tittel +10 more
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Zhongshan Daxue xuebao. Yixue kexue ban, 1989 用人新鲜胰腺癌组织免疫BALB/c小鼠,取脾细胞与小鼠骨髓瘤细胞Sp2/0-Agl4融合,获得了分泌抗人胰腺癌单克隆抗体的杂交瘤细胞株。本文重点报道以ABC免疫组织化学法检查YPC1单克隆抗体与人正常组织和肿瘤组织的反应性。结果表明YPC1单克隆抗体与16例被检测的胰腺癌组织发生反应。其中9例(56.3％)呈强阳性反应,与23种正常组织中的10种(43.5％)以及19种非胰腺肿瘤中的8种(42.1％)有不同程度的交叉反应,但多数反应较弱。本研究提示以新鲜人体肿瘤组织作为免疫原制备单克隆抗体是简便可行的 ...
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Research progress on the mechanism of organ-specific lung metastasis in pancreatic cancer [PDF]
, 2023 Pancreatic cancer is a highly malignant tumor of the digestive system. Due to the non-specific clinical symptoms in the early stage, its early diagnosis is very difficult.
YUE Ming, WANG Liwei, CUI Jiujie
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Research progress of MDSCs-targeted immunotherapy for pancreatic cancer [PDF]
, 2023 Pancreatic cancer (PC) is a highly malignant digestive system tumor with a poor survival rate and prognosis. Most patients with pancreatic cancer have no obvious clinical manifestations in the early stage of the disease, and are found to be in the middle
PENG Meiyu +4 more
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Leading research progress and prospect of antibody-drug conjugate in pancreatic cancer in 2022 [PDF]
, 2023 Pancreatic cancer is a type of malignant tumor with high incidence and low survival rate. It is urgent to develop novel and efficient therapeutic means for patients lacking surgical indications and patients with poor effects of radiotherapy and ...
ZENG Cheng, ZHANG Jian
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, 2017 目的：为借助分子影像技术提高抗肿瘤药物研发效率、降低研发成本提供参考。方法：以“分子影像技术”“药物研发”“肿瘤诊断”“生物标志物”等为关键词，通过检索和筛选中国知网、中国国家图书馆、PubMed、WebofScience等数据库收录的2017年4月以前发表的分子影像技术用于抗肿瘤药物研发的最新文献，进行整理、归纳和综述。结果与结论：近年来分子影像技术已取得重大进展，正越来越广泛地应用于抗肿瘤药物研发，并在药物生物分布标志物（药物由血液循环运送到体内各脏器的过程）、药效学生物标志物 ...
任恩, 刘刚, 高海燕
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The research on FBW7 gene enhances antitumor effect of paclitaxel on pancreatic cancer through GSDME-mediated pyroptosis [PDF]
, 2023 Background and purpose: Pancreatic cancer is a highly malignant disease. Most patients are in advanced stage upon diagnosis. Systemic chemotherapy is an important treatment method, but the chemotherapy drug resistance to tumors brings many problems to ...
JIA Yuming, YE Zeng, DENG Yanli, LI Shengchao, ZHANG Zhilei, WANG Chao, XU Xiaowu, QIN Yi, PENG Li
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Zhongguo shiyan zhenduanxue, 2020 目的探讨血清异常凝血酶原(PIVKA-II)在胰腺癌诊断中的应用价值。方法收集2018年1月至2019年6月于北京清华长庚医院初次诊断为胰腺癌的住院患者57例,胰腺炎患者50例,健康体检者50例,分别用化学发光法检测PIVKA-II、CA199、CEA、AFP,比较4个指标在胰腺癌组、胰腺炎组和健康对照组的差异,并作ROC曲线,比较PIVKA-II、CA199、CEA鉴别诊断胰腺良恶性疾病的效能;根据肿瘤位置,将胰腺癌组分为胰头癌组和胰体胰尾癌组,比较两组PIVKA-II、CA199、CEA水平的差异 ...
董静肖 +3 more
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