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肿瘤标志物联合检测与胰腺影像学检查在早期胰腺癌筛查诊断中的比较分析
Zhongguo shiyan zhenduanxue, 2015 胰腺癌是消化系统恶性程度很高的肿瘤。近年来其发病率有明显增加趋势[1]。由于胰腺位于腹膜后,位置深,早期无明显症状,故胰腺癌易被忽略而延误诊断,得不到及时有效的治疗。数十年来胰腺癌死亡率和生存率一直没有明显的改观。其主要原因是对胰腺癌早期诊断十分困难,各项生化检查对诊断胰腺癌意义不大,因此寻找理想的早期检测方法,建立早期诊断体系,成为世界医学界研究的热点 ...
史桂兰, 黄琳
doaj
Effects of Smad4 on the stemness in colon cancer cell and its underlying mechanism in vitro [PDF]
, 2017 研究背景与意义：结直肠癌(CRC)发生的分子机制尚不十分清楚，其发病原因和病因错综复杂，目前认为是在机体的内因与环境的外因相互作用的结果。近年来有越来越多的证据表明，结直肠癌干细胞的存在可能是导致肿瘤发生进展的重要原因之一。结直肠癌干细胞是肿瘤内非常小部分的细胞亚群，具有自我更新、形成异质性亚群，强耐药性并形成肿瘤的能力，因此它可能是肿瘤发生、耐药、转移和复发等各种恶性行为的源头。很多研究证实，Smad4作为TGF-β超家族信号通路中的关键分子，它的突变与结直肠癌的侵袭和转移密切相关 ...
杨文超
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Advances in basic research, clinical diagnosis and treatment of pancreatic cancer in 2023 [PDF]
Pancreatic cancer is a highly malignant digestive tract tumor with hidden symptoms, limited treatment options and rapid progression. With an increasing incidence rate year by year, pancreatic cancer has increasingly become a prominent issue endangering ...
LI Tianjiao, YE Longyun, JIN Kaizhou, WU Weiding, YU Xianjun
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Zhongguo shiyan zhenduanxue, 2010 目的先前利用胰腺癌患者血清筛选睾丸cDNA文库,获得胰腺癌相关抗原:TBC1D4。本研究分析TBC1D4在胰腺癌患者中的表达上调及其诱导的自身体液免疫应答。方法原核表达TBC1D4蛋白,金属镍鳌合亲和层析柱进行蛋白纯化,Western20blot检测22例胰腺癌患者的癌组织和对应癌旁组织TBC1D4表达情况;ELISA方法测定95胰腺癌患者与150例健康对照者血清中抗TBC1D4蛋白特异性抗体的水平。结果表达纯化重组蛋白TBC1D4,并诱导出多克隆抗体;胰腺癌癌组织TBC1D4蛋白表达水平显著上调 ...
姜小华 +7 more
doaj
Advances and Comments on Traditional Chinese Medicine Syndrome and Treatment on Pancreatic Cancer [PDF]
The advancements in innovative cancer prevention and treatment strategies have achieved remarkable results in the prevention and treatment of various malignant tumors. However, the increasing trend of incidence and mortality of pancreatic cancer (PC) has
Zhen CHEN
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Zhongguo shiyan zhenduanxue, 2011 胰腺癌是一种恶性度较高的肿瘤,其发病率呈逐年上升趋势,其预后较差,胰腺癌的早期诊断并行根治手术切除是胰腺癌最为有效的治疗手段。目前,螺旋CT增强扫描是早期诊断和术前评估胰腺癌最常用、最准确的影像学检查方法之一 ...
陶冶, 田力
doaj
Advantages and advances in neoadjuvant therapy of pancreatic cancer [PDF]
Due to the characteristics of the insidious onset, difficult early diagnosis and high malignancy of pancrea-tic cancer, only a minority of patients still have the chance of surgical resection at the time of diagnosis.
HU Binwei, SHEN Baiyong
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Zhongguo shiyan zhenduanxue, 2017 目的分析晚期胰腺癌患者血清CEA,CA199水平与肝转移的关系,探讨胰腺癌肝转移的危险因素。方法选取101例胰腺癌患者,主要根据有无肝转移分组,肝转移70例,无肝转移31例。采用化学发光免疫法对其血清标本中癌胚抗原（CEA）、糖抗原19-9（CA19-9）、糖抗原125（CA125）、糖抗原72-4（CA72-4）、细胞角蛋白21-1（CYFRA21-1）等项目进行检测。结果血清CA19-9、CA125水平的增高与胰腺癌肝转移具有相关性 ...
杨柳, 闫欢, 石燕, 戴广海
doaj
A case of pancreatic cancer treated with chemotherapy combined with immunotherapy and targeted therapy. [PDF]
Zhejiang Da Xue Xue Bao Yi Xue Ban, 2023 Zhang B, Tang K, Dong X.
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Composition Spectrum of Oral Microbiota Diversity in Patients with Pancreatic Cancer: A Systematic Review [PDF]
Objective To systematically evaluate the diversity of oral flora in patients with pancreatic cancer. Methods A cross-sectional study was conducted, focusing on the oral flora diversity profiles of patients with pancreatic cancer.
HUANG Hairong +2 more
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