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全球微生态药物研发现状及发展趋势 [PDF]

open access: yes, 2020
微生态药物在许多复杂性和慢性疾病中显示出极大的潜力,逐渐成为国际制药行业的新趋势。基于科睿唯安旗下的Cortellis数据库,采用定量分析和专家智慧相结合的方法,从总体研发现状、主要国家/地区、主要适应症、重点企业研发管线、重点在研药物、商业化交易多个维度展现全球微生态药物的研发和商业化全景。分析结果显示:全球共有142个在研微生态药物,其中49个药物处于临床阶段。美国在微生态药物研发和商业化方面遥遥领先,其数量占在研药物总量的70%。在研药物的适应症主要集中于炎症性肠病、艰难梭菌感染 ...
叶茂, 张宏翔, 江洪, 高倩
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Advances and Comments on Traditional Chinese Medicine Syndrome and Treatment on Pancreatic Cancer [PDF]

open access: yes
The advancements in innovative cancer prevention and treatment strategies have achieved remarkable results in the prevention and treatment of various malignant tumors. However, the increasing trend of incidence and mortality of pancreatic cancer (PC) has
Zhen CHEN
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New advances in basic research, clinical diagnosis and treatment of pancreatic cancer in 2024 [PDF]

open access: yes
Pancreatic cancer is a highly malignant tumor, and its incidence rate has been slowly increasing since 2000. Although the improvement of diagnosis and treatment has led to an increase in the five-year survival rate of pancreatic cancer compared to 50 ...
WANG Ting, QIN Yi, XU Xiaowu, YU Xianjun
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Review of the role of collagen in tumorigenesis and development [PDF]

open access: yes, 2023
Collagen is one of the most abundant proteins in the body and is the main component of the extracellular matrix. Collagen regulates cellular behavior, and its dysregulation can cause a variety of diseases, including cancer.
TANG Lei, XU Yingchun, ZHANG Fengchun
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Metabolomic Study on the Advanced Pancreatic Cancer Model in Nude Mouse [PDF]

open access: yes, 2016
胰腺癌是一种恶性程度极高的消化道类恶性肿瘤,早期无显著病征,病人在确诊时病情基本已处于中晚期,而研究显示,直径小于2cm和1cm的胰腺癌术后5年生存率分别可达30%-60%和超过75%,远高于中晚期术后5年生存率。 本文为课题“基于核磁共振的代谢组学技术发现胰腺癌的生物标志物及早期诊断应用”的一部分。整个课题目的在于通过系统分析动物和人类胰腺癌中晚期模型代谢通道的异同点,然后通过构建动物早期胰腺癌模型,并结合中晚期动物与人类胰腺癌代谢通路的共同点 ...
李志水
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Research progress on medical imaging-based artificial intelligence in precision diagnosis and treatment of pancreatic cancer [PDF]

open access: yes
Pancreatic cancer is a highly malignant tumor of the digestive tract, and its precision diagnosis and treatment is a major challenge in clinical practice.
Zhu Lubing, Wang Jianhua
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70例胰腺肿瘤的临床病理学特征分析

open access: yesZhongguo shiyan zhenduanxue, 2012
目的探讨胰腺肿瘤临床病理学特征、免疫组织化学染色及鉴别诊断。方法应用形态学观察、免疫组织化学染色回顾性分析70例胰腺肿瘤的临床及病理学特点。结果①70例胰腺肿瘤中患者年龄14-84岁,平均年龄53.3岁;女性40例(57.1%),男性30例(43.9%);肿瘤位于胰头42例(60.0%),胰体10例(14.3%),胰尾18例(25.7%)。②70例胰腺肿瘤中30例导管腺癌(42.9%),17例实性假乳头状肿瘤(24.3%),12例粘液性囊性肿瘤(17.1%),3例浆液性囊腺瘤(4.3 ...
张敏   +5 more
doaj  

Combining Low-dose Perfusion with Dual-energy CT Scanning for Pancreatic Neuroendocrine Tumors [PDF]

open access: yes
Objectives: This study explores the clinical value of one-time, low-dose pancreatic CT perfusion combined with dual-energy scanning for detecting pancreatic neuroendocrine tumors. Methods: We retrospectively analyzed data from 23 patients with surgically
Chunhui SHAN   +5 more
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胰胆系不同疾病之间肿瘤标志物水平比较研究

open access: yesZhongguo shiyan zhenduanxue, 2009
目的探讨各肿瘤标志物对胰胆系不同疾病诊断效能及其潜在其它临床应用价值。方法对我院2008年4月-2008年11月间119例不同胰胆系疾病患者,肿瘤患者均为术前血清标本,良性疾病患者采血前均无ERCP等有创检查或治疗,常规离心分离血清进行检测。利用美国雅培公司化学发光分析仪器及配套试剂进行检测,诊断标准以CA199>37(U/ml)、CA125>35(U/ml)、CEA>10(ng/ml)水平为阳性。结果①胰腺不同疾病间,比较各组之间肿瘤标志物等水平差异,统计分析结果,CA199(χ=28.113,P=0.
齐晓光, 王立夫, 孙罡, 林晓琳
doaj  

Advances in basic research, clinical diagnosis and treatment of pancreatic cancer in 2023 [PDF]

open access: yes
Pancreatic cancer is a highly malignant digestive tract tumor with hidden symptoms, limited treatment options and rapid progression. With an increasing incidence rate year by year, pancreatic cancer has increasingly become a prominent issue endangering ...
LI Tianjiao, YE Longyun, JIN Kaizhou, WU Weiding, YU Xianjun
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