Results 61 to 70 of about 2,545 (146)
Analysis of Chemical Composition and Pharmacological Activity of Fengdan Peony Pods [PDF]
The purpose of this study was to explore the bioactive components of Fengdan peony pods and their mechanisms of action by using network pharmacology and molecular docking.
ZHANG Yanping, ZHANG Chenxi, ZUO Haichao, GAO Di, WU Qiqi, SONG Yafei, ZHAO Liyuan
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Study for roles of the ARHI gene on gastric cancer MKN cells and involved signaling pathway [PDF]
, 2011 ARHI（AplysiarashomologI）是由YU等在1999年从人卵巢和乳腺上皮细胞及其癌细胞中克隆并命名，定位于人染色体1p31，全长8kb，包含2个外显子，一个内含子，编码26-KD的GTP结合蛋白。ARHI是一种单等位基因表达和母源性印迹的基因，它在肿瘤细胞中表达异常从而抑制肿瘤细胞的生长、运动和侵袭。核转录因子（nuclearfactor-κB）是1986年Sen和Baltimore首先于B淋巴细胞核抽提物中发现的一种结合于免疫球蛋白κ轻链增强子上的核蛋白。文献报道，NF ...
杨奕轩
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Mechanism study of KCMF1 promoting proliferation and NF-κB signaling transduction in colorectal cancer cells [PDF]
Background and purpose: Colorectal cancer (CRC) is one of the major malignant tumors threatening human health worldwide, with long-term high incidence and mortality rate.
WU Zhibai, XU Guiqin, ZHANG Li, YANG Zhaojuan, LIU Yun, JIAO Kun, CHEN Zehong, XU Chen, ZUO You, ZHENG Ningqian, YE Zhiqian, LIU Yongzhong
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Zhongguo shiyan zhenduanxue, 2018 胰岛细胞瘤（islet20cell20tumor,ICT）是属于胺前体摄取和脱羧（amine20precursor20uptake20and20decarboxylation,APUD）细胞系统,可以合成和分泌多种激素,临床症状表现多样的罕见胰腺肿瘤,其发病率为0.43/10000[1]。根据ICT是否具有内分泌功能分为功能性（胰岛素瘤、胃泌素瘤、胰高血糖素瘤、生长抑素瘤、舒血管肠肽瘤）和无功能性两大类 ...
高娟娟, 王清
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假基因来源的lncRNA DUXAP8表观遗传沉默CDKN1A和KLF2促进胰腺癌细胞的生长 [PDF]
, 2019 背景与目的最近研究表明假基因来源的长链非编码RNA(long non-coding RNAs,lncRNA)是癌症的关键调控因子。然而,在胰腺癌中却鲜有对lncRNA的鉴定和研究。我们旨在明确假基因来源的lncRNA DUXAP8与胰腺癌细胞生长的关系。方法我们通过比较分析3个来自GEO的独立数据集,筛选出与人胰腺癌相关的假基因来源的lncRNA。通过实时定量反转录PCR检测DUXAP8在胰腺癌组织和细胞中的相对表达水平。应用功能缺失的方法在体外和体内研究DUXAP8对胰腺癌细胞的增殖和凋亡的作用 ...
Chuangxing Xiao +5 more
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Zhongguo shiyan zhenduanxue, 2012 近年来,2型糖尿病和恶性肿瘤的发病率逐年增加,并且2型糖尿病与恶性肿瘤同时发病的人数也在不断增加,严重危及患者生命。研究表明,2型糖尿病是恶性肿瘤的高危因素[1],糖尿病可增加恶性肿瘤的发病率。糖尿病与人类常见恶性肿瘤如结、直肠癌,肝癌,胰腺癌,乳腺癌以及子宫内膜癌等都有一定的关联[2]。糖尿病导致恶性肿瘤发病率增加的确切发病机制尚不清楚 ...
韩倩 +5 more
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Preparation of Selenium-enriched Morchella Polysaccharide and Its Antitumor Activity in Vitro [PDF]
This study aimed to optimize the extraction and purification processes for selenium-enriched Morchella esculenta (L.) Pers. (also known as Morchella) polysaccharides (Se-MPS) and to evaluate their anti-tumor activities and mechanisms.
Beibei LI, Huiqin WANG, Yizheng SUN
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Logistic回归及ROC曲线综合评价超声造影对胰腺癌诊断的应用价值
Zhongguo shiyan zhenduanxue, 2019 胰腺癌是临床上较常见的消化道恶性肿瘤,其发病率呈逐年递增的趋势,根据美国癌症协会(ACS)于2017年发布的流统学数据表明,美国胰腺癌患病人数在男性中已上升到第11位、女性上升到第8位,其死亡人数在肿瘤死亡人数中高居第4位[1 ...
周红云 +3 more
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Zhongguo shiyan zhenduanxue, 2013 研究表明,高迁移率族蛋白B1（HMGB1）作为一种核内非组蛋白,在肿瘤的发生、发展及转移中起着重要的作用。HMGB1在结肠癌、乳腺癌、前列腺癌、非小细胞肺癌、胰腺癌等人类恶性肿瘤组织中,均出现过度表达,并与肿瘤发生、发展以及患者预后等密切相关[1]。新近有研究显示,血清HMGB1水平在胃癌、肝癌、非小细胞肺癌、宫颈癌中升高 ...
汤夏冰, 李蕾, 沈晓辉, 陈国千
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An exploratory study of INPP4B, a biomarker of gemcitabine chemoresistance in pancreatic cancer [PDF]
Background and purpose: Pancreatic cancer is a highly aggressive solid tumor of the digestive system, with radical resection being unfeasible in approximately 80% of patients due to the absence of specific clinical manifestations in the early stages. The
REN Jiaqiang, WU Shuai, SU Tong, LI Jie, HAN Liang, WU Zheng
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