Results 1 to 10 of about 7,855 (132)
Zhongguo cuzhong zazhi, 2022 目的 探讨磷脂酰肌醇3激酶/蛋白激酶B（phosphatidylinositol-3-kinase/protein kinase B，PI3K/PKB）信号通路介导脂联素对脑缺血再灌注大鼠的保护作用。 方法 随机将SD大鼠分为假手术组、模型组、脂联素治疗组和PI3K/PKB抑制剂LY294002组（抑制剂组），每组15只。通过线栓法构建大脑中动脉缺血模型，缺血1.5 h后再灌注。脂联素治疗组在再灌注2 h后，给予大鼠尾静脉注射脂联素（180 μg/100 g）；抑制剂组在再灌注2 ...
何俊芳, 刘新平, 吕学海, 王斌
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Journal of Diabetes, Volume 15, Issue 12, Page 1020-1028, December 2023., 2023 Highlights Childhood obesity was significantly associated with the increased risk of insulin resistance (IR). There were 12 metabolites co‐associated with childhood obesity and IR, including seven amino acid and five fatty acid metabolites. The combination of body mass index standard deviation score and key metabolites could effectively predict the ...
Wu Yan +5 more
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Journal of Diabetes, Volume 15, Issue 10, Page 881-889, October 2023., 2023 Highlights Serum low‐density lipoprotein cholesterol (LDL‐C) levels were positively and significantly associated with a high risk of incident diabetes. Even in participants with normal LDL‐C levels (<130 mg/dL), a 1‐SD increase in LDL‐C levels was significantly associated with a higher risk of diabetes development.
Jiaojiao Huang +13 more
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Journal of Diabetes, Volume 15, Issue 3, Page 204-214, March 2023., 2023 Highlights The first multicenter, large‐sample study of the relationship between remnant cholesterol (RC) and diabetes. RC is independently associated with diabetes. RC represents residual diabetes risk beyond traditional lipids. Abstract Background The association between remnant cholesterol (RC) and diabetes remains unclear because of limited study ...
Binqi Li +11 more
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Journal of Diabetes, Volume 14, Issue 6, Page 365-376, June 2022., 2022 HighlightsAssociation of lipid variability with diabetic microvascular complications. Abstract Background Greater lipid variability may cause adverse health events among diabetic patients. We aimed to examine the effect of lipid variability on the risk of diabetic microvascular outcomes among type 2 diabetes mellitus patients.
Daniel Nyarko Hukportie +6 more
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Journal of Diabetes, Volume 14, Issue 4, Page 271-281, April 2022., 2022 Highlights The gender‐specific role of sphingolipids in obesity‐related metabolic dysfunctions is unclear. The aim of this study is to identify ceramide species by liquid chromatography‐mass spectrometry that accumulate in central fat in relation to status of diabetes and gender for subjects with a body mass index ≥40 kg/m2 or > 35 kg/m2 with ...
Michelle Brusatori +7 more
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MMC celebrating 6 years of experience and expansion 庆祝MMC六年的经验和壮大
, 2022 Journal of Diabetes, Volume 14, Issue 5, Page 356-357, May 2022.
Itamar Raz
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Renoprotective effects of brown adipose tissue activation in diabetic mice 棕色脂肪激活对糖尿病小鼠的肾脏保护作用
Journal of Diabetes, Volume 11, Issue 12, Page 958-970, December 2019., 2019 Highlights This study demonstrates that of brown adipose tissue (BAT) with CL316,243 attenuates the progress of diabetic kidney disease (DKD). Mechanistically, the activation of BAT improved concentrations of circulating adipokines and microRNAs, which further affected the diabetic kidney and reactivated the AMP‐activated protein kinase/sirtuin 1 ...
Ying‐Ying Cai +10 more
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Developmental Medicine &Child Neurology, Volume 61, Issue 3, Page E1-E35, March 2019., 2019 目的 本国际临床指南由欧洲残疾儿童学会（the European Academy of Childhood Disability，EACD）牵头制定，旨在解决发育性协调障碍（developmental coordination disorder，DCD）的定义、诊断、评估、干预以及与社会心理方面的临床应用关键问题。 方法 本指南针对五个领域的关键问题，通过文献综述和专家团队的正式讨论达成共识。为保证指南的循证基础，以“机制”、“评估”和“干预”为检索词, 对2012年更新以来提出的最新建议以及新增的“社会心理问题”和“青少年/成人”为检索词进行检索。根据牛津大学循证医学中心证据等级 (证据水平 [level of evidence, LOE]1–4) 将结果进行分类，最终转化为指南建议。并由国际 ...
Jing Hua +6 more
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Zhongguo shiyan zhenduanxue, 2022 目的 探讨CT检测腹部脂肪含量在多发性骨髓瘤（multiple myeloma,MM）患者预后中的价值。方法 同时对36例新诊断MM(NDMM)患者和72例健康者腹部CT脂肪含量的检查。主要测量T12到S1的总脂肪面积（TFA）、内脏脂肪面积（VFA）和皮下脂肪面积（SFA）并进行相关分析，同时检测脂联素水平。结果 与健康人相比，NDMM患者的TFA、VFA和SFA均更高，而血浆脂联素显著降低。骨髓浆细胞百分比与SAT呈显著负相关，但与VFA/SFA呈正相关 ...
高珊 +6 more
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