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茵陈蒿汤主成分治疗代谢相关脂肪性肝病的配伍剂量优化及作用机制实验研究 [PDF]
浙江大学学报. 医学版目的探讨茵陈蒿汤主效应组分栀子苷、绿原酸和大黄多糖改善代谢相关脂肪性肝病（MAFLD）的最佳剂量配比和作用机制。方法将C57BL/6小鼠随机分为正常对照组、模型对照组、均匀设计1~6组、茵陈蒿汤组。除正常对照组外，其余各组采用西方饮食饲料建立MAFLD模型，均匀设计1~6组和茵陈蒿汤组在造模8周后通过灌胃给予相应药物。12周后处死所有小鼠，称取小鼠的体重和肝脏质量，苏木精-伊红染色观察肝组织病理学变化，检测血浆丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）水平，检测血浆及肝脏总胆固醇（TC）、甘油三酯（
高 艳艳 +5 more
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Journal of Diabetes, Volume 15, Issue 12, Page 1070-1080, December 2023., 2023 Highlights Lipid profiles of small extracellular vesicles (sEVs) in patients with diabetes or diabetic cardiovascular disease are rarely reported. n‐3 docosahexaenoic acid (DHA)‐enriched triacylglycerol (TG) was found to decrease in sEVs from serum of patients with diabetic cardiovascular disease (DM‐CAD).
Wei Ding +3 more
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Journal of Diabetes, Volume 15, Issue 12, Page 1020-1028, December 2023., 2023 Highlights Childhood obesity was significantly associated with the increased risk of insulin resistance (IR). There were 12 metabolites co‐associated with childhood obesity and IR, including seven amino acid and five fatty acid metabolites. The combination of body mass index standard deviation score and key metabolites could effectively predict the ...
Wu Yan +5 more
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Journal of Diabetes, Volume 15, Issue 11, Page 968-977, November 2023., 2023 Highlights Among 301 studies, diabetes mellitus was the most studied cardiometabolic risk factor. In the network meta‐analysis, cerebrovascular disease had the highest impact (relative risk [RR] 1.69; 95% CI, 1.65–1.73) on COVID‐19 outcomes compared to other cardiometabolic risk factors.
Alina Binbin Li +9 more
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Journal of Diabetes, Volume 15, Issue 11, Page 987-993, November 2023., 2023 Highlights We used data from the genome‐wide association studies database and two‐sample mendelian randomization method, we found that genetic evidence supporting that knee osteoarthritis is a potential risk factor for type 2 diabetes. Abstract Background Physical inactivity is an independent risk factor for type 2 diabetes (T2D).
Xing Xing +3 more
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Journal of Diabetes, Volume 15, Issue 10, Page 900-910, October 2023., 2023 Highlights Mild acquired impaired thyroid hormone sensitivity was widespread among the general populations. Reduced thyroid hormone sensitivity was related with metabolic syndrome and its components. Impaired thyroid hormone sensitivity might affect the distribution of adipose tissue and muscle.
Fang Lv +6 more
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Journal of Diabetes, Volume 15, Issue 10, Page 817-837, October 2023., 2023 Highlights Type 2 diabetes mellitus (T2DM) is characterized by progressive loss of beta‐cell function and mass. Numerous mechanisms of beta‐cell failure are involved. Preservation and/or enhancement of beta‐cell function is of great importance in delaying the progression of T2DM and the burden of its complications. Accurate evaluation of the effects of
Laure Sayyed Kassem +3 more
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Journal of Diabetes, Volume 15, Issue 9, Page 777-786, September 2023., 2023 Highlights Increased glutamate is associated with the development of diabetes. Glutamate increases plasminogen (PLG) levels through glutamate metabotropic receptor 5 activation with various insulin resistance‐related stresses. Glutamate inhibits the conversion of PLG to plasmin by increasing plasminogen activator inhibitor‐1.
Hyo Jung Lee +7 more
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Journal of Diabetes, Volume 15, Issue 9, Page 787-798, September 2023., 2023 Highlights Laparoscopic sleeve gastrectomy and laparoscopic Roux‐en‐Y gastric bypass are effective for reducing weight and improving metabolic parameters in Chinese patients with obesity. These interventions resulted in improved glycemic control, as evidenced by decreased glycated hemoglobin levels, reduced insulin resistance, and improved ...
Wenhuan Feng +6 more
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Mechanisms of bariatric surgery for weight loss and diabetes remission 减重手术减轻体重和缓解糖尿病的机制
Journal of Diabetes, Volume 15, Issue 9, Page 736-752, September 2023., 2023 Highlights Controversial changes in intestinal hormones after bariatric surgery (BS) were summarized. The changes of signaling proteins involved in insulin resistance and the newly proposed changes in growth differentiation factor 15, exosomes, and extracellular vesicles after BS were elucidated.
Mengsha Yin +6 more
wiley +1 more source