Results 11 to 20 of about 303,265 (151)
Linchuang shenzangbing zazhi, 2016 糖尿病肾脏疾病（diabetic kidney disease,DKD）是糖尿病微血管并发症之一,病理变化表现为肾小球及肾小管肥大、肾小球及肾小管基膜增厚和肾小球硬化等,其发病机制复杂,炎症、氧化应激、生化代谢紊乱、内皮损伤、蛋白尿、遗传易感性等机制均参与其中。脂联素是脂肪组织中含量最丰富的转录产物之一,自其首次被发现以来,Yamauchi等[1]首先用分子克隆技术确定了两种脂联素受体,即脂联素受体1（AdipoR1）和脂联素受体2（AdipoR2）。随后Hug等[2]发现T ...
王鸳鸳 +3 more
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Zhongshan Daxue xuebao. Yixue kexue ban, 2009 【目的】 研究孕晚期血清脂联素水平与产后糖代谢转归的关系,为产后糖代谢持续异常患者的早期预测和干预提供依据65377; 【方法】 对我院规律产检并住院分娩的68名妊娠期糖代谢异常患者进行前瞻性研究,分析孕晚期脂联素水平及其它孕期指标与产后糖代谢的关系65377;【结果】 39名妊娠期糖代谢异常患者于产后6 ~ 8周复诊时行75 g OGTT试验,持续存在糖代谢异常者为11名,其中空腹血糖受损(IFG)1例,糖耐量受损(IGT)10例65377;产后IGT者和产后糖耐量正常者(NGT)相比 ...
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Zhongshan Daxue xuebao. Yixue kexue ban, 2013 目的】 探讨血管紧张素II 1型受体拮抗剂替米沙坦对自发性高血压大鼠(SHR)糖代谢及血清脂联素的影响。 【方法】 实验分为4组: 对照组(WKY,n = 10);高血压组(SHR,n = 10);替米沙坦组(替米沙坦,50 mg·kg-1·d-1,n = 10),氨氯地平组(氨氯地平 10 mg·kg-1·d-1,n = 10),另外两组给予安慰剂,均为灌胃法给药,12周后处死大鼠,用生化方法测定糖代谢指标,ELISA方法测定血清脂联素含量。【结果】 四组大鼠空腹血糖之间没有明显差异(P > 0.05)
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Zhongshan Daxue xuebao. Yixue kexue ban目的探究雌性大鼠性早熟对糖代谢和脂代谢的影响。方法将60只两天龄的雌性大鼠随机分为性早熟组和正常组两组，分别在5天龄时给予达那唑（300 μg/只）或溶剂大豆油进行皮下注射，从21天龄起每天观察大鼠的阴道开口状况。建模成功的两组按照阴道开口顺序分别于阴道开口后3 d、7周龄和12周龄进行处死，处死前空腹12 h。方法测量麻醉后的体重和鼻肛长，通过酶联免疫吸附试验测量葡萄糖、胰岛素、血脂、雌二醇、瘦素和脂联素的浓度，病理切片观察肾周脂肪、子宫和卵巢的变化。结果通过正常组和早熟组两组3个时间点对比 ...
林小雅 +7 more
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Journal of Diabetes, Volume 15, Issue 12, Page 1020-1028, December 2023., 2023 Highlights Childhood obesity was significantly associated with the increased risk of insulin resistance (IR). There were 12 metabolites co‐associated with childhood obesity and IR, including seven amino acid and five fatty acid metabolites. The combination of body mass index standard deviation score and key metabolites could effectively predict the ...
Wu Yan +5 more
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Journal of Diabetes, Volume 15, Issue 10, Page 881-889, October 2023., 2023 Highlights Serum low‐density lipoprotein cholesterol (LDL‐C) levels were positively and significantly associated with a high risk of incident diabetes. Even in participants with normal LDL‐C levels (<130 mg/dL), a 1‐SD increase in LDL‐C levels was significantly associated with a higher risk of diabetes development.
Jiaojiao Huang +13 more
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Journal of Diabetes, Volume 15, Issue 3, Page 204-214, March 2023., 2023 Highlights The first multicenter, large‐sample study of the relationship between remnant cholesterol (RC) and diabetes. RC is independently associated with diabetes. RC represents residual diabetes risk beyond traditional lipids. Abstract Background The association between remnant cholesterol (RC) and diabetes remains unclear because of limited study ...
Binqi Li +11 more
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Journal of Diabetes, Volume 14, Issue 6, Page 365-376, June 2022., 2022 HighlightsAssociation of lipid variability with diabetic microvascular complications. Abstract Background Greater lipid variability may cause adverse health events among diabetic patients. We aimed to examine the effect of lipid variability on the risk of diabetic microvascular outcomes among type 2 diabetes mellitus patients.
Daniel Nyarko Hukportie +6 more
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Journal of Diabetes, Volume 14, Issue 4, Page 271-281, April 2022., 2022 Highlights The gender‐specific role of sphingolipids in obesity‐related metabolic dysfunctions is unclear. The aim of this study is to identify ceramide species by liquid chromatography‐mass spectrometry that accumulate in central fat in relation to status of diabetes and gender for subjects with a body mass index ≥40 kg/m2 or > 35 kg/m2 with ...
Michelle Brusatori +7 more
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MMC celebrating 6 years of experience and expansion 庆祝MMC六年的经验和壮大
, 2022 Journal of Diabetes, Volume 14, Issue 5, Page 356-357, May 2022.
Itamar Raz
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