Results 11 to 20 of about 6,081 (157)

The link between obesity and insulin resistance among children: Effects of key metabolites 儿童肥胖与胰岛素抵抗之间的联系:关键代谢产物的影响

Journal of Diabetes, Volume 15, Issue 12, Page 1020-1028, December 2023., 2023
Highlights Childhood obesity was significantly associated with the increased risk of insulin resistance (IR). There were 12 metabolites co‐associated with childhood obesity and IR, including seven amino acid and five fatty acid metabolites. The combination of body mass index standard deviation score and key metabolites could effectively predict the ...
Wu Yan, Su Wu, Qianqi Liu, Qingqing Zheng, Wei Gu, Xiaonan Li   +5 more
wiley   +1 more source

Association between serum LDL‐C concentrations and risk of diabetes: A prospective cohort study 血清低密度脂蛋白胆固醇浓度与糖尿病风险之间的关联: 一项前瞻性队列研究

Journal of Diabetes, Volume 15, Issue 10, Page 881-889, October 2023., 2023
Highlights Serum low‐density lipoprotein cholesterol (LDL‐C) levels were positively and significantly associated with a high risk of incident diabetes. Even in participants with normal LDL‐C levels (<130 mg/dL), a 1‐SD increase in LDL‐C levels was significantly associated with a higher risk of diabetes development.
Jiaojiao Huang, Hong Lin, Shuangyuan Wang, Mian Li, Tiange Wang, Zhiyun Zhao, Yu Xu, Min Xu, Jieli Lu, Yuhong Chen, Guang Ning, Weiqing Wang, Yufang Bi, Long Wang   +13 more
wiley   +1 more source

Remnant cholesterol is independently associated with diabetes, even if the traditional lipid is at the appropriate level: A report from the REACTION study 即使传统脂质处于适当水平, 残留胆固醇与糖尿病独立相关:来自REACTION研究的报告

Journal of Diabetes, Volume 15, Issue 3, Page 204-214, March 2023., 2023
Highlights The first multicenter, large‐sample study of the relationship between remnant cholesterol (RC) and diabetes. RC is independently associated with diabetes. RC represents residual diabetes risk beyond traditional lipids. Abstract Background The association between remnant cholesterol (RC) and diabetes remains unclear because of limited study ...
Binqi Li, Xin Zhou, Weiqing Wang, Zhengnan Gao, Li Yan, Guijun Qin, Xulei Tang, Qin Wan, Lulu Chen, Zuojie Luo, Guang Ning, Yiming Mu   +11 more
wiley   +1 more source

Lipid variability and risk of microvascular complications in Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial: A post hoc analysis 控制糖尿病心血管风险的行动(ACCORD)试验中的血脂变异性和微血管并发症风险:一项事后分析

Journal of Diabetes, Volume 14, Issue 6, Page 365-376, June 2022., 2022
HighlightsAssociation of lipid variability with diabetic microvascular complications. Abstract Background Greater lipid variability may cause adverse health events among diabetic patients. We aimed to examine the effect of lipid variability on the risk of diabetic microvascular outcomes among type 2 diabetes mellitus patients.
Daniel Nyarko Hukportie, Fu‐Rong Li, Rui Zhou, Jia‐Zhen Zheng, Xiao‐Xiang Wu, Meng‐Chen Zou, Xian‐Bo Wu   +6 more
wiley   +1 more source

Ceramide changes in abdominal subcutaneous and visceral adipose tissue among diabetic and nondiabetic patients 糖尿病和非糖尿病患者腹部皮下和内脏脂肪组织神经酰胺的变化

Journal of Diabetes, Volume 14, Issue 4, Page 271-281, April 2022., 2022
Highlights The gender‐specific role of sphingolipids in obesity‐related metabolic dysfunctions is unclear. The aim of this study is to identify ceramide species by liquid chromatography‐mass spectrometry that accumulate in central fat in relation to status of diabetes and gender for subjects with a body mass index ≥40 kg/m2 or > 35 kg/m2 with ...
Michelle Brusatori, Michael H. Wood, Stephanie C. Tucker, Krishna Rao Maddipati, S. Kiran Koya, Gregory W. Auner, Kenneth V. Honn, Berhane Seyoum   +7 more
wiley   +1 more source

MMC celebrating 6 years of experience and expansion 庆祝MMC六年的经验和壮大

, 2022
Journal of Diabetes, Volume 14, Issue 5, Page 356-357, May 2022.
Itamar Raz
wiley   +1 more source

Renoprotective effects of brown adipose tissue activation in diabetic mice 棕色脂肪激活对糖尿病小鼠的肾脏保护作用

Journal of Diabetes, Volume 11, Issue 12, Page 958-970, December 2019., 2019
Highlights This study demonstrates that of brown adipose tissue (BAT) with CL316,243 attenuates the progress of diabetic kidney disease (DKD). Mechanistically, the activation of BAT improved concentrations of circulating adipokines and microRNAs, which further affected the diabetic kidney and reactivated the AMP‐activated protein kinase/sirtuin 1 ...
Ying‐Ying Cai, Hong‐Bin Zhang, Cun‐Xia Fan, Yan‐Mei Zeng, Shao‐Zhou Zou, Chun‐Yan Wu, Ling Wang, Shu Fang, Ping Li, Yao‐Ming Xue, Mei‐Ping Guan   +10 more
wiley   +1 more source

International clinical practice recommendations on the definition, diagnosis, assessment, intervention, and psychosocial aspects of developmental coordination disorder – Chinese (Mandarin) translation

Developmental Medicine &Child Neurology, Volume 61, Issue 3, Page E1-E35, March 2019., 2019
目的 本国际临床指南由欧洲残疾儿童学会（the European Academy of Childhood Disability，EACD）牵头制定，旨在解决发育性协调障碍（developmental coordination disorder，DCD）的定义、诊断、评估、干预以及与社会心理方面的临床应用关键问题。 方法 本指南针对五个领域的关键问题，通过文献综述和专家团队的正式讨论达成共识。为保证指南的循证基础，以“机制”、“评估”和“干预”为检索词, 对2012年更新以来提出的最新建议以及新增的“社会心理问题”和“青少年/成人”为检索词进行检索。根据牛津大学循证医学中心证据等级 (证据水平 [level of evidence, LOE]1–4) 将结果进行分类，最终转化为指南建议。并由国际 ...
Jing Hua, Wenchong Du, Xiaotian Dai, Meiqin Wu, Xianying Cai, Min Shen, Liping Zhu   +6 more
wiley   +1 more source

Ficus carica leaves extractimprove lipid metabolism in skeletal muscle of offspring rat with chronic intrauterine hypoxia [PDF]

, 2017
目的 探讨无花果叶提取物（FCLE）对慢性宫内缺氧成年子鼠骨骼肌脂质代谢的影响,及其潜在分子机制。方法 随机将24只SD孕鼠分为常氧组、缺氧组及给药组,分别进行慢性宫内缺氧干预及子鼠出生后8周FCLE灌胃治疗。比色法检测血液学指标、骨骼肌脂肪含量、氧化状态以及RT-PCR法检测骨骼肌脂质代谢相关蛋白表达。结果与常氧组相比,缺氧组子鼠血脂水平升高,出现胰岛素抵抗且骨骼肌脂质含量明显增多[分别为（42.3±5.5）μmol/g、（59.9±6.4）μmol/g,P〈0.05];脂联素、脂联素受体1 ...
丁小明, 游剑虹, 程晶, 黄丹丹
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The role and mechanism of hypoxia on lipid metabolism in liver of HFD mice [PDF]

, 2017
背景：非酒精性脂肪性肝病（NAFLD）是指除外酒精和其他明确的损肝因素所致的，以弥漫性肝细胞大泡性脂肪变为主要特征的临床病理综合症。然而NAFLD的发病机制并不明确，目前比较公认的是“二次打击”学说。近年来，有文献报道缺氧与肝脏脂质代谢密切相关，并且在临床中肥胖病人和呼吸暂停综合症（OSA）病人同时患有非酒精性脂肪肝的概率非常高。 目的：根据高脂饮食（highfatdiet，HFD）与NAFLD疾病的关系，探索HFD跟缺氧之间的联系以及缺氧在脂肪肝发病过程中所起的作用，研究缺氧诱导肝脏脂质堆积的机制 ...
张晓芳
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