Results 11 to 20 of about 6,662 (153)
Journal of Diabetes, Volume 15, Issue 12, Page 1081-1094, December 2023., 2023 Highlights Glucagon receptor (GCGR) monoclonal antibody (mAb) improves cardiac function and attenuates microvascular damage in db/db mice. GCGR mAb ameliorates the oxidative stress of cardiac microvascular endothelial cells in diabetic mice. GCGR mAb counteracts the diabetes‐induced upregulation of carnitine palmitoyltransferase 1B, optic atrophy type ...
Peng Wang +6 more
wiley +1 more source
Journal of Diabetes, Volume 13, Issue 2, Page 143-153, February 2021., 2021 Highlights A machine learning model can significantly predict imminent development of islet autoimmunity based on environmental, genetic, and metabolic features. The machine learning algorithm feature selection identified type 1 diabetes‐associated single nucleotide polymorphisms from The Environmental Determinants of the Diabetes in the Young (TEDDY ...
Bobbie‐Jo M. Webb‐Robertson +10 more
wiley +1 more source
Rare Metals, Volume 45, Issue 3, March 2026.ABSTRACT Aqueous vanadium dioxide (VO2)‐based smart thermal insulation coatings represent a viable strategy to decrease building energy consumption and advance sustainable development goals. However, the inherent instability and limited compatibility with polymer matrices of VO2 hinder its widespread application.
Xiuxian Zhao +9 more
wiley +1 more source
Response mechanism of phytoplankton to reduced seawater acidity/salinity and petroleum hydrocarbon pollution [PDF]
, 2016 浮游植物是海洋主要初级生产者，在海洋生态系统的物质循环和能量流动中起十分重要作用。由于温室效应气体CO2的加剧排放，全球变暖、海冰融化、海平面上升，导致海洋酸度和盐度下降。同时，随着海上石油开发及运输的日益发展，海洋石油泄露事故在全球各地频发，石油烃污染已成为全球主要的海洋污染物之一。 本文针对海水酸度和盐度下降及石油烃污染胁迫下，海洋浮游植物的生理生态响应及其对微量元素生物地球化学循环的影响的科学问题，以浮游植物生物量、抗氧化能力、脂质过氧化、光致产生活性氧等4种指标来探讨浮游植物的生理生态响应 ...
刘凤娇
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Progress in epigenetic modification of ferroptosis involved in chronic obstructive pulmonary disease [PDF]
Ferroptosis is a special type of programmed cell death, which is different from autophagy, apoptosis and other modes of death, and characterized by mitochondrial shrinkage, membrane density increase and ridge reduction.
CAI Xiaoyu +3 more
core +1 more source
Role of oxidative stress in trichloroethylene-induced toxicity [PDF]
, 2022 Trichloroethylene (TCE) is a common industrial organic solvent and environmental contaminant. People are exposed to TCE through occupational contact or environmental pollution, which leads to serious human health hazards.
Jinfeng ZHAO +4 more
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Rare Metals, Volume 45, Issue 2, February 2026.ABSTRACT Intervertebral disc degeneration (IDD) is a predominant cause of low back pain, significantly impacting quality of life. Mitochondrial fitness is essential in the progression of IDD, as it regulates cellular senescence and pyroptosis. This study investigates the role of mitochondrial caseinolytic protease P (ClpP) in alleviating senescence and
Kun Wang +7 more
wiley +1 more source
Toxicity of Cadmium and Its Bioaccumulation in Spotted Babylon,Babylonia areolata: Comparison between Effects of Waterborne and Dietary Exposure [PDF]
, 2013 为比较直接经水体与经营养传递的2种镉(CAdMIuM,Cd)暴露方式对方斑东风螺(bAbylOnIA ArEOlATA)不同组织Cd蓄积和毒性的差异,采用室内模拟法,将螺暴露于含Cd水体(Cd2+:100μg·l-1)或喂食含Cd饵料(牡蛎,34.56μg·g-1以干质量计,先经水体100μg·l-1Cd2+暴露达平衡)30d后再进行15d净化。结果显示,暴露期间,除食物相组螺胃肠道Cd浓度在第10天极显著高于对照组,但随后迅速下降外,其他各组织在2种途径及胃肠道在水相暴露时Cd的浓度均逐渐上升 ...
柯才焕, 薛明
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Advances in Elemene Nanodelivery Systems: From Material Design to Disease Treatment
Rare Metals, Volume 45, Issue 2, February 2026.ABSTRACT Elemene (ELE) is a bioactive sesquiterpenoid extracted from traditional Chinese herbs, demonstrating broad‐spectrum antitumor, anti‐inflammatory, and analgesic properties with significant therapeutic potential. However, its clinical utility is constrained by inherent physicochemical limitations, including volatility and hydrophobicity, which ...
Xiao Wang +9 more
wiley +1 more source
Molecular mechanism of the role of ROS signaling pathway in the antioxidant properties of TKE2 cells [PDF]
, 2016 目的:目前ROS在干细胞生物学中的作用还没有得到充分说明和了解。在过氧化氢（H2O2）诱导的氧化应激条件下，我们比较小鼠角膜上皮祖细胞（TKE2）[1]和成熟的小鼠角膜上皮细胞（MCE）的不同反应，重点研究是角膜干细胞的抗氧化细胞特性及相关机制。 方法:以小鼠角膜上皮祖细胞（TKE2）和成熟的小鼠角膜上皮细胞（MCE）为细胞模型，通过CCK8细胞活性实验检测不同浓度H2O2对小鼠角膜上皮的祖细胞（TKE2）和成熟的小鼠角膜上皮细胞（MCE）的影响。利用H2O2处理细胞24小时后 ...
葛连平
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