Results 11 to 20 of about 5,711 (152)
Journal of Diabetes, Volume 15, Issue 12, Page 1081-1094, December 2023., 2023 Highlights Glucagon receptor (GCGR) monoclonal antibody (mAb) improves cardiac function and attenuates microvascular damage in db/db mice. GCGR mAb ameliorates the oxidative stress of cardiac microvascular endothelial cells in diabetic mice. GCGR mAb counteracts the diabetes‐induced upregulation of carnitine palmitoyltransferase 1B, optic atrophy type ...
Peng Wang +6 more
wiley +1 more source
Journal of Diabetes, Volume 13, Issue 2, Page 143-153, February 2021., 2021 Highlights A machine learning model can significantly predict imminent development of islet autoimmunity based on environmental, genetic, and metabolic features. The machine learning algorithm feature selection identified type 1 diabetes‐associated single nucleotide polymorphisms from The Environmental Determinants of the Diabetes in the Young (TEDDY ...
Bobbie‐Jo M. Webb‐Robertson +10 more
wiley +1 more source
Advances in Elemene Nanodelivery Systems: From Material Design to Disease Treatment
Rare Metals, EarlyView.ABSTRACT Elemene (ELE) is a bioactive sesquiterpenoid extracted from traditional Chinese herbs, demonstrating broad‐spectrum antitumor, anti‐inflammatory, and analgesic properties with significant therapeutic potential. However, its clinical utility is constrained by inherent physicochemical limitations, including volatility and hydrophobicity, which ...
Xiao Wang +9 more
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Rare Metals, EarlyView.ABSTRACT Lung cancer remains the leading cause of cancer‐related deaths worldwide, yet immune checkpoint blockade (ICB) is often compromised by an immunosuppressive tumor microenvironment (TME) with acidosis, hypoxia, and poor T cell infiltration. Here, we develop a TME‐responsive nanoplatform (MgH2@Lip/PD‐L1) that couples hydrogen gas therapy with PD ...
Xuyu Gu +5 more
wiley +1 more source
Progress in epigenetic modification of ferroptosis involved in chronic obstructive pulmonary disease [PDF]
Ferroptosis is a special type of programmed cell death, which is different from autophagy, apoptosis and other modes of death, and characterized by mitochondrial shrinkage, membrane density increase and ridge reduction.
CAI Xiaoyu +3 more
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Role of oxidative stress in trichloroethylene-induced toxicity [PDF]
, 2022 Trichloroethylene (TCE) is a common industrial organic solvent and environmental contaminant. People are exposed to TCE through occupational contact or environmental pollution, which leads to serious human health hazards.
Jinfeng ZHAO +4 more
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Toxicity of Cadmium and Its Bioaccumulation in Spotted Babylon,Babylonia areolata: Comparison between Effects of Waterborne and Dietary Exposure [PDF]
, 2013 为比较直接经水体与经营养传递的2种镉(CAdMIuM,Cd)暴露方式对方斑东风螺(bAbylOnIA ArEOlATA)不同组织Cd蓄积和毒性的差异,采用室内模拟法,将螺暴露于含Cd水体(Cd2+:100μg·l-1)或喂食含Cd饵料(牡蛎,34.56μg·g-1以干质量计,先经水体100μg·l-1Cd2+暴露达平衡)30d后再进行15d净化。结果显示,暴露期间,除食物相组螺胃肠道Cd浓度在第10天极显著高于对照组,但随后迅速下降外,其他各组织在2种途径及胃肠道在水相暴露时Cd的浓度均逐渐上升 ...
柯才焕, 薛明
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Functional Ecology, Volume 39, Issue 5, Page 1274-1287, May 2025.Read the free Plain Language Summary for this article on the Journal blog. Abstract Interactions between plants and soil microorganisms in the rhizosphere are vital for maintaining the nutrient cycle and stability of terrestrial ecosystems. Nitrogen, closely related to carbon (C) cycling and ecosystem productivity, undergoes transformation by soil ...
Ru Wang +9 more
wiley +1 more source
地下储油与地上储油对油脂品质的影响Effect of underground storage and above-ground storage on oil quality
Zhongguo youzhi, 2022 油脂在储存过程中，其品质指标易受温度等因素的影响。将大豆原油和菜籽原油储存于室外地上和埋于室外地下的钢制储罐，定期取样测定油脂的水分及挥发物、酸值、过氧化值、色泽、挥发性成分、脂肪酸组成、反式脂肪酸含量、氧化稳定性及甾醇和维生素E含量,考察不同储油方式对大豆原油和菜籽原油品质的影响。结果表明：地下储油温度变化较小，基本在11~27 ℃之间，地上储油温度变化较大，最高接近45 ℃，最低接近0 ℃；地上、地下储油中均未检出反式脂肪酸，储油方式对油脂水分及挥发物、色泽、脂肪酸组成影响较小；储存12个月时，地上、
秦绍昆1，张学娣1，陆峰1，王彬1，刘玉兰2 QIN Shaokun1, ZHANG Xuedi1, LU Feng1, WANG Bin1, LIU Yulan2
doaj +1 more source
Molecular mechanism of the role of ROS signaling pathway in the antioxidant properties of TKE2 cells [PDF]
, 2016 目的:目前ROS在干细胞生物学中的作用还没有得到充分说明和了解。在过氧化氢（H2O2）诱导的氧化应激条件下，我们比较小鼠角膜上皮祖细胞（TKE2）[1]和成熟的小鼠角膜上皮细胞（MCE）的不同反应，重点研究是角膜干细胞的抗氧化细胞特性及相关机制。 方法:以小鼠角膜上皮祖细胞（TKE2）和成熟的小鼠角膜上皮细胞（MCE）为细胞模型，通过CCK8细胞活性实验检测不同浓度H2O2对小鼠角膜上皮的祖细胞（TKE2）和成熟的小鼠角膜上皮细胞（MCE）的影响。利用H2O2处理细胞24小时后 ...
葛连平
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