Zhongshan Daxue xuebao. Yixue kexue ban, 2002 【目的】建立环磷酰胺(CTX)预处理脐血移植(UCBT)小鼠模型, 并探讨预处理后骨髓龛位腾出的特点和机制。 【方法】分别以100 , 200 , 380 mg/ kg 3 种剂量CTX 腹腔注射BALB/ c 小鼠, 检测注射后1 周内外周血象、骨髓及外周血CD34 + 细胞含量、骨髓细胞凋亡及病理学改变。用C57BL/6 鼠脐血(FNPB)作供体移植经“ 致死量”CTX 预处理的BALB/ c 鼠, 动态 观察移植后受鼠存活状况、植入水平、造血与免疫功能恢复及移植物抗宿主病(GVHD)情况 ...
徐宏贵, 黄文革
doaj
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