高浓度雌二醇对刀豆蛋白A诱导小鼠急性自身免疫性肝炎的影响 [PDF]
Zhongshan Daxue xuebao. Yixue kexue ban, 2021 目的研究高浓度雌激素（EE）对急性自身免疫性肝炎（AIH）的影响，并初步探索其可能的作用机制。方法通过小鼠尾静脉注射刀豆蛋白A，建立急性自身免疫性肝炎模型。将20只8周龄雌性C57BL/6小鼠按体质量随机区组分组，分为4组：对照（Control）组，刀豆蛋白A（ConA）组，雌二醇（EE）组和雌二醇+刀豆蛋白组（EE+ConA），每组5只。雌鼠卵巢去势，分别持续腹腔注射雌二醇2周，最后一次给药24 h后，尾静脉注射刀豆蛋白A。模型的评估采用苏木素-伊红染色法和血清ATL和AST测定法 ...
张译文 +5 more
doaj +2 more sources
浙江大学学报. 医学版肝脏作为机体新陈代谢的核心器官，深度调节体内各类营养物质的合成及代谢。铁死亡作为一种铁依赖性的脂质过氧化物积累引起的新型细胞程序性死亡方式，参与多种急慢性肝疾病的生理和病理进程。目前认为，在急性肝损伤、代谢相关脂肪性肝病、酒精性肝病、病毒性肝炎、自身免疫性肝炎等大部分肝疾病中，铁死亡可加速疾病进程；而在晚期肝纤维化和肝细胞癌中，铁死亡则延缓疾病进程。因此，靶向调控铁死亡能够有效预防并延缓急慢性肝疾病的发生发展。本文讨论了铁死亡在急性肝损伤、代谢相关脂肪性肝病、酒精性肝病、病毒性肝炎、自身免疫性肝炎 ...
李 欣 +5 more
doaj +2 more sources
Recent Developments in Stem Cells from Human Exfoliated Deciduous Teeth in the Treatment of Non-oral Diseases [PDF]
, 2023 Stem cells from human exfoliated deciduous teeth (SHEDs) are odontogenic stem cells with strong proliferation ability and multilineage differentiation potential.
JIANG Zhihan, XU Ling
core +1 more source
Role of oxidative stress in trichloroethylene-induced toxicity [PDF]
, 2022 Trichloroethylene (TCE) is a common industrial organic solvent and environmental contaminant. People are exposed to TCE through occupational contact or environmental pollution, which leads to serious human health hazards.
Jinfeng ZHAO +4 more
core +2 more sources
Current Status of PD-1/PD-L1 Anti-tumor Therapy and Exploration of the Mechanism of Immune-related Adverse Events [PDF]
, 2022 Programmed cell death protein-1 (PD-1) and programmed death ligand 1 (PD-L1) inhibitors are a group of immune checkpoint inhibitors. Since May 2006, there have been 10 immune checkpoint inhibitors targeting PD-1 and PD-L1 for tumor treatment. Although PD-
YANG Leiyi, LIN Sang, XIE Qibing, YIN Geng
core +1 more source
25(OH)D与儿童全身型幼年特发性关节炎疾病活动度的关系探讨
Zhongguo shiyan zhenduanxue, 2021 全身型幼年特发性关节炎(SJIA)是幼年特发性关节炎(JIA)的一种亚型,典型表现为发热、皮疹、关节痛、多浆膜炎、肝大和/或脾大,仅占JIA发病率的10%左右,但致死率及致残率较高,目前认为是自身炎症反应综合征。近几年大量的研究表明,维生素D可参与体内固有免疫调节及适应性免疫调节过程,在多种自身免疫条件下发挥重要作用,
康宇辰 +3 more
doaj +2 more sources
Meta-analysis of Curative Effects and Safeties of Baraclude Versus Other Nucleoside Drugs for Treatment of HBeAg-positive Chronic Hepatitis B [PDF]
, 2017 目的：评价博路定和其他抗乙肝病毒核苷酸类药物对核苷初治的乙型肝炎 e 抗原（HBeAg）阳性慢性乙型肝炎（CHB）患者的疗效和安全性。方法：计算机检索 PubMed、Mestre、中国期刊全文数据库（CNKI）、中文科技期刊数据库（VIP）、万方数据库（建库至2015年10月）公开发表的有关博路定和其他抗乙肝病毒核苷酸类药物对核苷初治的 HBeAg 阳性 CHB 患者疗效的随机对照试验（RCTs），并追查已获文献的参考文献。由两名研究者独立筛选文献，提取数据，按照改良后 Jadad 评分标准进行质量评价。
严国鸿 +5 more
core +1 more source
Correlation analysis of bile acid spectrum and thyroid function in patients with autoimmune liver disease [PDF]
"Objective To explore the correlation between bile acid metabolic components and thyroid function indicators in patients with autoimmune liver disease（AILD）.
SONG Keyu，QIAO Runjie，WANG Wenjing，ZHANG Qin，TAN Guolei
core +2 more sources
Research progress in the role of M1/M2 polarization of macrophages in different liver diseases [PDF]
Macrophages have strong plasticity and heterogeneity, and can undergo functional transformation in response to different signal stimuli, such as classical activation of M1 type (M1 type polarization) and selective activation of M2 type (M2 type ...
LI Zhengju +5 more
core +1 more source
The association study between the polymorphisms in P53 and MDM2 and the genetic susceptibility of primary hepatocellular carcinoma among Xiamen population [PDF]
, 2015 目的 探讨厦门市P53基因rs1042522位点、MDM2基因rs2279744位点的单核苷酸多态性（SNP）与原发性肝细胞癌（HCC）遗传易感性的关系，为筛检肝癌高危人群，以及进行肝癌一、二级预防提供参考依据。 方法 采用病例-对照研究设计，抽样调查在2011年1月至2014年10月间厦门市综合性三甲医院就诊的肝癌患者和健康对照者。病例组纳入标准：根据HCC诊断依据在调查期间被首次确诊为HCC、年龄≥18岁、现住址与调查地属同一区（县）级范围、无任何其他肿瘤史的患者。排除标准：患有HCC以外的肿瘤 ...
潘欢欢
core