Results 21 to 30 of about 25,505 (191)

Tolerability and Feasibility of Minimally Invasive Canine Skin Sampling: Excellent Tolerability Meets Transcriptomic Challenges

open access: yesVeterinary Dermatology, EarlyView.
ABSTRACT Background Advances in transcriptomics have driven the demand for minimally invasive, reproducible and high‐yield skin sampling methods, particularly for studying inflammatory skin diseases in companion animals. Hypothesis/Objectives We tested tolerability, feasibility and RNA quantity and quality of three minimally invasive skin sampling ...
Ina Herrmann   +2 more
wiley   +1 more source

遗传性肾脏病基因诊断和高通量测序技术在诊断中的应用进展

open access: yesLinchuang shenzangbing zazhi, 2016
一、遗传性肾脏病的诊断1.遗传性疾病概述遗传性疾病包括单基因遗传病、多基因遗传病和染色体病,单基因遗传病种类多但发生率低,大多是罕见病,大约7 000多种,是由一个基因的序列异常导致的遗传性疾病,又可以分为常染色体隐性遗传病、常染色体显性遗传病和性连锁遗传和线粒体病。多基因遗传疾病约有100多种,都是常见疾病 ...
周建华
doaj  

血清C-反应蛋白和胱抑素-C检测在2型糖尿病肾病早期诊断中的价值

open access: yesZhongguo shiyan zhenduanxue, 2020
2型糖尿病是糖尿病中最常见的一种类型,作为慢性终身代谢性疾病,其致残、致死率较高,发生2型糖尿病后若血糖未得到较好的控制,随着病情进展可导致各种并发症,糖尿病肾病是最严重的并发症之一,早期糖尿病肾病往往无明显症状、体征,其可从不同途径对肾脏造成损害,导致肾功能衰退、衰竭,是2型糖尿病患者残疾或死亡的一个主要影响因素[1]。
宋继英
doaj  

The Research on the Interaction Domains among Three Major envelope Proteins and their Interaction with Chitin [PDF]

open access: yes, 2015
对虾白斑综合症病毒(WSSV)是严重阻碍对虾养殖业健康发展的主要病害之一。WSSV是一种无包涵体、具双层囊膜、杆状型的双链环状大型DNA病毒,其基因组大约为300kbp,隶属于线形病毒科(Nimaviridae)白斑病毒属(Whispovirus)。WSSV宿主范围广,能对对虾和多种甲壳动物造成高致病性、高死亡率的感染,然而病毒侵染宿主的机制至今仍不清楚。在本研究中,我们鉴定了病毒3种主要囊膜蛋白VP24、VP26和VP28之间的相互作用位点。此外,我们也首次发现WSSV可以与几丁质结合 ...
李在鹏
core  

Functions of Non-coding Small RNA in Pathogenic Bacteriaand Its New Methodology [PDF]

open access: yes, 2017
细菌中的非编码小RNA(small; RNA,sRNA)作为一种靶向调控分子在细胞生理代谢过程中具有重要作用。sRNA作用于特定靶标,调控基因的表达。大肠杆菌大约有100种sRNA,; 其中1 /3; sRNA需要伴侣蛋白Hfq的介导。病原细菌中sRNA分子如何调控致病基因的表达,目前研究仍处于初级阶段。本文将从生物膜形成、细菌耐药性以及对宿主; 的影响等方面,结合新颖的sRNA的研究方法,综述sRNA在调控代谢网络及控制病原菌致病性方面的作用。The small non-coding RNA as a
张智, 李娜, 王岱
core   +1 more source

Development of a Four‐Language Questionnaire to Investigate Environmental Risk Factors for the Development of Canine Atopic Dermatitis and to Monitor Disease Course and Progression

open access: yesVeterinary Dermatology, Volume 37, Issue 1, Page 34-44, February 2026.
Background: The chronic and multifactorial character of canine atopic dermatitis (cAD) often leads to poor disease control and treatment dissatisfaction. Environmental factors are likely to contribute to the disease development and may play a more important role than assumed previously.
Patricia Clara‐Maria Rhodius   +11 more
wiley   +1 more source

1型心肾综合征的发病机制研究进展

open access: yesZhongguo shiyan zhenduanxue, 2013
1型心肾综合征(CRS)是指急性失代偿期心衰(ADHF)、急性冠脉综合征、急性心源性休克以及心脏外科手术、冠状动脉造影等相关操作引起的急性肾损伤(AKI)。实验证明,多种病理生理机制同时或续贯作用致血肌酐升高、少尿、利尿剂抵抗,使失代偿期心衰患者病情加重,导致心肾综合征的发生。而患有慢性肾脏疾病的情况下,肥胖、恶病质、高血压、糖尿病、蛋白尿、钠水潴留、贫血、重叠感染、免疫反应、脓毒血症以及医源性因素导致了1型心肾综合征的发生。氧化应激是导致心肾损伤,发生CRS的最终共同通路 ...
李明   +4 more
doaj  

Dry and Wet Deposition Characteristics and Anthropogenic Sources of Atmospheric Mercury in Xiamen [PDF]

open access: yes, 2016
大气汞是危害人体健康的毒性污染物。大气中不同形态的汞具有不同的理化特性,颗粒态总汞TPM(Totalparticulatemercury)沉降速率高,能在排放源附近沉降,对区域内的生态环境造成较大的危害;大气气态总汞TGM(Totalgaseousmercury)因其具有较低的水溶性和沉降速率,可在大气中停留0.5-2年,能够进行长距离传输,被认为是全球性污染物。目前欧美地区已经广泛地建立起汞监测网络,虽然国内的大气汞监测也陆续开展起来,但是长时间持续监测尚不多见。本研究基于实验室前期的研究成果 ...
陈强
core  

Multi‐Scale Rational Design and Synergistic Strategies of Nanozymes for Targeting Drug‐Resistant Pathogens

open access: yesRare Metals, Volume 45, Issue 1, January 2026.
ABSTRACT The escalating issue of drug‐resistant pathogens, largely driven by the overuse of conventional antibiotics, has become a significant global health threat. Developing alternative therapeutic strategies and fabricating natural biological enzyme materials that mimic the high efficiency, selectivity, and mild‐operating conditions of natural ...
Shuai He   +11 more
wiley   +1 more source

外伤性眼内炎的病原学诊断及相关因素分析

open access: yesZhongguo shiyan zhenduanxue, 2013
眼内炎是非常凶险的感染性致盲性眼病,常常造成视功能损害甚至导致视力丧失更有甚者眼球摘除。眼外伤特别是开放性眼外伤,因眼球壁的完整性被破坏,病原微生物易于经过开放的伤口或伴随致伤物进入眼内从而引起化脓性炎症。因眼外伤导致的眼内炎早期诊断,病原学检查,早期治疗 ...
尚彦霞
doaj  

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