Results 51 to 60 of about 25,505 (191)

Climate and Land‐Use Changes Predicted to Jointly Drive Soil Fungal Diversity Losses in One‐Third of North American Coniferous Forests

open access: yesGlobal Change Biology, Volume 31, Issue 11, November 2025.
This study assessed the potential impacts of climate and land‐use change on soil fungal diversity across four North American biomes. We found that climate change typically caused both diversity losses and gains, particularly in coniferous forests and among arbuscular mycorrhizal fungi, whereas land‐use change mainly reduced diversity, especially in ...
Wenqi Luo   +5 more
wiley   +1 more source

肌钙蛋白与C反应蛋白联合检测在急性心肌梗死诊断中的意义

open access: yesZhongguo shiyan zhenduanxue, 2012
急性心肌梗死(acute myocardial infarction,AMI)是因持久而严重的心肌缺血所致的部分心肌急性坏死,缺血常由冠状动脉急性闭塞导致血流中断,是缺血性心脏病的表现之一[1],也是临床上较为常见的多发病,发病急并且病死率高,是全球性致死和严重致残的原因之一[2]。因此对急性心肌梗死早期发现、早期诊断和早期治疗就是抢救的关键。目前对AMI的预防和诊断是研究的热点问题,而临床上对AMI的诊断主要是通过心绞痛前驱症状、体征、心电图 ...
刘艳
doaj  

Establishment and Application of Respiratory Syncytial Virus Animal Model [PDF]

open access: yes, 2016
人呼吸道合胞病毒(HumanRespiratorySyncytiaVirus,hRSV)是全球范围内引起下呼吸道感染主要病原体之一。其感染人群年龄分布广,新生儿与老年人是主要高危人群。据报道,几乎所有小于2周岁婴幼儿都有RSV感染经历,婴幼儿发病住院率高达2.5-4%。RSV引起大于65周岁的老年人感染率为3-4%,病死率约为2%。早产儿、先天性心脏病、先天性支气管及肺发育不良、免疫缺陷的婴幼儿RSV病死率率高达5%,造成严重的医疗负担。 RSV无安全、有效疫苗上市 ...
詹炉停
core  

Validation of the Equine Urticaria Activity Score for the assessment of chronic recurrent urticaria in horses

open access: yesVeterinary Dermatology, Volume 36, Issue 5, Page 630-637, October 2025.
Background – Recurrent urticaria is common in horses. The pathophysiology is poorly understood and treatment options are limited. Often only glucocorticoids are effective for controlling clinical signs, albeit with potential adverse effects. Studies investigating new treatments need a validated objective scoring system for the grading of skin lesions ...
Katharina Birkmann   +5 more
wiley   +1 more source

The establishment of Elispot-based neutralization assay for HCMV and its application in epidemiological study [PDF]

open access: yes, 2013
人巨细胞病毒(humancytomegalovirus,HCMV)的感染在全球普遍存在。HCMV感染一般以潜伏状态存在,当机体免疫力低下时,则易发生再激发感染,引起严重甚至威胁生命的感染性疾病。在自然感染过程中,HCMV可感染包括淋巴细胞,上皮细胞以及内皮细胞在内的多种类型的细胞。HCMV体外培养体系的宿主细胞主要是上皮细胞及成纤维细胞。传统的基于细胞病变的TCID50以及空斑形成减少实验检测样本中和滴度的方法,存在周期长,操作繁杂,主观因素影响大的缺点,不适合大样本量的临床研究 ...
赵利利
core  

Synopsis of the antimicrobial use guidelines for canine pyoderma by the International Society for Companion Animal Infectious Diseases (ISCAID)

open access: yesVeterinary Dermatology, Volume 36, Issue 5, Page 552-565, October 2025.
Abstract Background Canine pyoderma is one of the most common presentations in small animal practice, frequently leading to antimicrobial prescribing. Objectives To provide clinicians with antimicrobial treatment guidelines for staphylococcal pyoderma, including those involving meticillin‐resistant staphylococci.
Anette Loeffler   +9 more
wiley   +1 more source

Treatment of refractory severe dry eye with 0.1% tacrolimus eyedrops [PDF]

open access: yes, 2016
目的:评估0.1%他克莫司滴眼液治疗难治性重度干眼疗效。 方法:本研究招募已使用人工泪液合并激素治疗半年或半年以上,但干眼症状及体征未见明显缓解的重度干眼患者26名。所有给予0.1%他克莫司滴眼液合并人工泪液治疗,并于治疗前、治疗后1月、2月及3月观察干眼相关临床指标,包括:干眼症状评分(OcularSurfaceDiseaseIndex,OSDI)、泪膜破裂时间(Tearbreakuptime,TBUT)、泪液分泌试验(SchirmerI)、角膜荧光素钠染色评分 ...
杨舒
core  

胸腺肽α1对老年慢性阻塞性肺疾病急性发作患者细胞免疫功能的影响

open access: yesZhongguo shiyan zhenduanxue, 2012
慢性阻塞性肺疾病(COPD)是呼吸系统常见疾病,常见于老年患者,因为机体慢性缺氧、疾病全身炎症反应可致免疫功能下降,后者又使机体更容易招致感染,加速肺功能的损害,增加患者的致残率及死亡率。免疫增强剂能提高机体的免疫力,减少机体受感染的机会。本文探讨胸腺肽α1治疗后对老年慢性阻塞性肺疾病急性发作(AECOPD)患者免疫功能影响及临床疗效。
金艳坤   +5 more
doaj  

包括NMES在内的康复方案对COPD患者临床肺康复效果研究

open access: yesZhongguo shiyan zhenduanxue, 2022
monaryDisease,COPD),简称“慢阻肺”,是一种存在持续临床表现和不完全可逆气流受限为特点的慢性呼吸系统疾病,是我国常见的慢性呼吸系统疾病[1]。最近发表的流行病学调查结果显示,我国≥20岁成人慢阻肺患病率为8.6%,≥40岁则高达13.7%,估算我国慢阻肺患病人数约9 990万,慢阻肺导致的死亡率和疾病负担单病种排名均居第三位[2],我国慢阻肺现状不容乐观,COPD患者时常会有慢性和进行性呼吸困难,咳嗽,痰多等症状这使得患者有很大身体负担,导致活动受限,最终导致慢性阻塞性肺病(COPD ...
doaj  

Research of TTA1,Tat,PEG modified gelatin-siloxane combined with siRNA transfecting C6 cells and inhibiting its EGFR gene expression [PDF]

open access: yes, 2016
背景:脑胶质瘤是颅内最常见的恶性肿瘤,其预后差,治疗效果不佳,患者平均生存期短一直是世界性难题。近年来,随着现代医学和分子生物学的发展,基因治疗广受医学界的关注。RNA干扰(RNAi)是目前极具前景的脑胶质瘤基因治疗手段之一。脑胶质瘤基因治疗的关键因素之一在于基因载体系统。理想的基因载体系统,应具有能够穿透血脑屏障的能力、较高的基因转染效率、良好的胶质瘤细胞靶向性和生物相容性以及较高的稳定性和安全性等优点。本课题以明胶硅氧烷纳米粒子(GSNPs)修饰上亲水性聚乙二醇(PEG ...
胡洋
core  

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