[Bioinformatic analysis of venetoclax sensitivity and resistance mechanisms in acute myeloid leukemia]. [PDF]
Zhonghua Xue Ye Xue Za Zhi目的 探究维奈克拉对急性髓系白血病（AML）的抑癌作用及耐药机制。 方法 从Beat AML数据库下载BCL-2抑制剂维奈克拉药敏试验的AML患者基因组、转录组及临床信息数据，对其与药敏试验结果进行相关性分析。通过对转录组数据进行差异分析，筛选出与维奈克拉治疗敏感性相关的差异基因并使用GEO数据库转录组结果及体外实验进行验证。同时应用KEGG、GSEA以及KnockTF转录因子富集分析及公共数据库进一步探讨影响药物敏感性的关键基因。 结果 过滤得到52例进行维奈克拉药敏试验的患者数据。分析结果表明 ...
Yang Y +7 more
europepmc +2 more sources
急性白血病体外药物敏感性测定——一种简便、迅速、切实可行的方法 [PDF]
Zhongshan Daxue xuebao. Yixue kexue ban, 1985 用96孔培养板培养病人骨髓白血病细胞作药物抑制氚标记脱氧胸苷(~3H-TdR)参入试验。对14例白血病患者作26次试验,结果表明13例急性白血病24次试验药物在体外对~3H-TdR参入的抑制率与临床用药疗效相当一致,阿糖胞苷和三尖杉酯碱对~3H-TdR参入细胞的抑制试验可以有效地预测疗效,本法与其他试验方法比较,具有迅速简便,切实可行等优点。慢粒急变1例作2次试验,结果与临床疗效不一致。急性白血病的治疗一向以化疗为主,不同病人或不同病期对化疗药物的敏感性均不同 ...
苏勇庄
doaj +2 more sources
Distribution of blood culture pathogens and clinical characteristics in children with acute leukemia complicated with septic shock [PDF]
, 2022 Objective To explore the distribution of blood culture pathogens and clinical characteristics in children with acute leukemia complicated with septic shock.
Liu Tinghua, Lei Jiaying, Mai Yougang
core +1 more source
Combined use of venetoclax and azacitidine in treatment of acute myeloid leukemia complicated with disseminated Fusarium infection: a case report [PDF]
, 2022 Acute myeloid leukemia （AML） is a malignant clonal disease originating from hematopoietic stem/progenitor cells. Chemotherapy is the main treatment. If not effectively treated after 2 courses of standard treatment， these patients can be diagnosed with ...
Guo Jun, Wei Pei, Tong Yajun, Chen Ting
core +1 more source
Non-clostridial Gas-forming Infection in Diabetes：Clinical Analysis of Two Cases [PDF]
, 2022 Non-clostridial organism can produce pneumoderma by breaking down sugar and other substrates in necrotic tissues, and non-clostridial gas-forming infection is usually seen in diabetic patients with poor glycemic control.
WU Yuan, LYU Hongjun, YAO Xiaoli, LIU Juan
core +1 more source
Analysis of contamination and pathogenic characteristics of Salmonella in the processing of pre-packed cooked meat products [PDF]
, 2023 ObjectiveTo analyze the molecular characteristics and antibiotic susceptibility of Salmonella isolates and investigate the contamination of Salmonella in pre-packed cooked meat products during food processing.MethodsAccording to the sampling requirements
LIU Weichao +3 more
core +1 more source
Changes in drug resistance of Acinetobacter baumannii during the change of meropenem concentration in the environment and its mechanism [PDF]
, 2023 Objective·To explore the mechanism of changes in resistance to meropenem (MEM), a carbapenem drug, in Acinetobacter baumannii (A. baumannii) cultured in different antibiotic concentrations.Methods·Through changing the MEM concentration and ...
PENG Li +4 more
core +1 more source
Analysis of the pathogenic characteristics of two food poisoning events caused by Clostridium perfringens in Shunyi District, Beijing [PDF]
, 2020 Objective To investigate the pathogenic characteristics of Clostridium perfringens isolated from two diarrhea outbreaks. Methods Samples and specimens of patients, chefs, cooking utensils and suspicious foods involved in 2 diarrhea outbreaks were ...
Hongbo JING +6 more
core +1 more source
荧光PCR探针熔解曲线法检测结核分枝杆菌耐利福平突变研究 [PDF]
, 2011 目的对荧光PCR熔解曲线法检测结核分枝杆菌耐利福平突变方法进行临床研究,评价检测能力及在国境口岸的应用价值。方法应用荧光PCR熔解曲线法检测结核病人临床分离结核分枝杆菌,以传统药物敏感性试验为标准,获得该方法的灵敏性、特异性。结果对347例结核病人临床分离培养样本,传统药物敏感性试验检出271例利福平敏感标本,76例利福平耐药标本。荧光PCR熔解曲线法检出269例利福平敏感标本,78例利福平耐药标本,灵敏性为93.42%,特异性为97.42%,符合率为96.54%。结论荧光PCR熔解曲线法检测速度快速 ...
李庆阁 +4 more
core
荧光PCR熔解曲线法检测结核分枝杆菌耐利福平突变研究 [PDF]
, 2011 目的对荧光PCR熔解曲线法检测结核分枝杆菌耐利福平突变方法进行临床研究,评价其检测效能及在国境口岸应用价值。方法应用荧光PCR熔解曲线法检测结核病人临床分离标本,与传统药物敏感性试验对比,衡量该方法的灵敏度、特异性。结果对347例结核病人临床分离培养样本,药敏试验检出271例利福平敏感标本,76例利福平耐药标本;荧光PCR熔解曲线法检出269例利福平敏感标本,78例利福平耐药标本,灵敏度为93.42%,特异性为97.42%,符合率为96.54%。结论荧光PCR熔解曲线法检测速度快速、灵敏度高、特异性强 ...
李庆阁, 李辉, 赵东阳, 马艳艳
core