Results 11 to 20 of about 6,048 (140)
The Oncologist, Volume 24, Issue 7, Page e542-e550, July 2019., 2019 Abstract Background Antiangiogenesis tyrosine kinase inhibitors (TKIs) have been shown to prolong progression‐free survival (PFS) in advanced osteosarcoma. Methylsulfonic apatinib is a TKI that specifically inhibits vascular endothelial growth factor receptor‐2.
Lu Xie +6 more
wiley +1 more source
Analysis of the pathogenic characteristics of two food poisoning events caused by Clostridium perfringens in Shunyi District, Beijing [PDF]
, 2020 Objective To investigate the pathogenic characteristics of Clostridium perfringens isolated from two diarrhea outbreaks. Methods Samples and specimens of patients, chefs, cooking utensils and suspicious foods involved in 2 diarrhea outbreaks were ...
Hongbo JING +6 more
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Developmental Medicine &Child Neurology, Volume 61, Issue 3, Page E1-E35, March 2019., 2019 目的 本国际临床指南由欧洲残疾儿童学会（the European Academy of Childhood Disability，EACD）牵头制定，旨在解决发育性协调障碍（developmental coordination disorder，DCD）的定义、诊断、评估、干预以及与社会心理方面的临床应用关键问题。 方法 本指南针对五个领域的关键问题，通过文献综述和专家团队的正式讨论达成共识。为保证指南的循证基础，以“机制”、“评估”和“干预”为检索词, 对2012年更新以来提出的最新建议以及新增的“社会心理问题”和“青少年/成人”为检索词进行检索。根据牛津大学循证医学中心证据等级 (证据水平 [level of evidence, LOE]1–4) 将结果进行分类，最终转化为指南建议。并由国际 ...
Jing Hua +6 more
wiley +1 more source
荧光PCR探针熔解曲线法检测结核分枝杆菌耐利福平突变研究 [PDF]
, 2011 目的对荧光PCR熔解曲线法检测结核分枝杆菌耐利福平突变方法进行临床研究,评价检测能力及在国境口岸的应用价值。方法应用荧光PCR熔解曲线法检测结核病人临床分离结核分枝杆菌,以传统药物敏感性试验为标准,获得该方法的灵敏性、特异性。结果对347例结核病人临床分离培养样本,传统药物敏感性试验检出271例利福平敏感标本,76例利福平耐药标本。荧光PCR熔解曲线法检出269例利福平敏感标本,78例利福平耐药标本,灵敏性为93.42%,特异性为97.42%,符合率为96.54%。结论荧光PCR熔解曲线法检测速度快速 ...
李庆阁 +4 more
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Veterinary Dermatology, Volume 36, Issue 3, Page 291-301, June 2025.Background – Canine interdigital furunculosis (CIF) is a complex, relapsing inflammatory condition, typically complicated by deep bacterial infections requiring prolonged systemic antibiotics. Hypothesis/Objectives – This split‐body study, where dogs acted as their own control, evaluated whether the adjunctive use of fluorescent light energy (FLE ...
A. Lange +12 more
wiley +1 more source
Veterinary Dermatology, Volume 36, Issue 3, Page 234-282, June 2025.Background – Canine pyoderma is one of the most common presentations in small animal practice, frequently leading to antimicrobial prescribing. Objectives – To provide clinicians with antimicrobial treatment guidelines for staphylococcal pyoderma, including those involving meticillin‐resistant staphylococci.
Anette Loeffler +9 more
wiley +1 more source
荧光PCR熔解曲线法检测结核分枝杆菌耐利福平突变研究 [PDF]
, 2011 目的对荧光PCR熔解曲线法检测结核分枝杆菌耐利福平突变方法进行临床研究,评价其检测效能及在国境口岸应用价值。方法应用荧光PCR熔解曲线法检测结核病人临床分离标本,与传统药物敏感性试验对比,衡量该方法的灵敏度、特异性。结果对347例结核病人临床分离培养样本,药敏试验检出271例利福平敏感标本,76例利福平耐药标本;荧光PCR熔解曲线法检出269例利福平敏感标本,78例利福平耐药标本,灵敏度为93.42%,特异性为97.42%,符合率为96.54%。结论荧光PCR熔解曲线法检测速度快速、灵敏度高、特异性强 ...
李庆阁, 李辉, 赵东阳, 马艳艳
core
, 2013 患者,男,71岁,既往无药物过敏史。因左上肺癌并纵隔淋巴结肿大,胸骨、肋骨多发转移入院,行第2周期gP联合重组人血管内皮抑制素化学治疗。治疗第10天,患者诉头晕、疲劳、乏力、食欲差,咳嗽时感觉胸骨刺痛不适,无恶心、呕吐、反酸,无腹痛、腹泻等不适。体格检查示体温36.5℃,脉搏90次/分,呼吸16次/分,血压120/80 MMHg,各心脏瓣膜区未闻及病理性杂音,腹部无明显阳性体征。当日嘱生脉注射液(上海和黄药业有限公司,批号为20110914)40 Mg+5%葡萄糖注射液250 Ml静脉滴注,益气养阴 ...
曾敏珍, 王艺红
core
Zhongguo shiyan zhenduanxue, 2021 目的通过回顾性分析医院尿路感染病原菌的分布和耐药性情况,为临床合理使用抗菌药物提供理论依据。方法收集医院2017-2018年中段尿标本进行培养,采用法国生物梅里埃公司VITEK-2Compact全自动细菌鉴定仪进行细菌鉴定和药敏试验;采用法国梅里埃ATB Express半自动细菌鉴定药敏仪进行真菌鉴定和药敏试验,结果用WHONET5.6软件进行数据统计分析。结果 5 049份尿标本中共分离出1 439株细菌和假丝酵母菌,分离率为28.50%。病原菌以革兰阴性杆菌为主,占60.25%,假丝酵母菌占20 ...
吴亚, 赵红丽
doaj
PCR-探针熔解分析法检测结核分枝杆菌氟喹诺酮耐药基因突变的临床应用评价 [PDF]
, 2011 目的评价PCR-探针熔解分析法(PMAA)检测结核分枝杆菌(MTB)氟喹诺酮(FQ)药物耐药性的临床应用价值。方法采用常规比例法和PCR-PMAA对509株MTB临床分离株进行FQ药物敏感性试验。对69株比例法和(或)PCR-PMAA法检测耐药以及440株两法检测均敏感的MTB菌株中抽取的55株菌株,进行FQ药物耐药相关基因gyrA和gyrBPCR-DNA测序。结果以常规比例法为标准,PCR-PMAA检测FQ药物耐药性的敏感性、特异性、阳性和阴性预测值、符合率及约登指数分别为97.01%、99.55 ...
张灵霞 +4 more
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