Results 21 to 30 of about 225,740 (120)

Hybrid Probiotic Hydrogel With Curcumin‐Loaded MnO2 Nanoparticles Enhances Diabetic Wound Healing Through Multimodal Microenvironmental Regulation

open access: yesRare Metals, Volume 45, Issue 3, March 2026.
ABSTRACT Skin wound injuries are often accompanied by bacterial infections and severe inflammation. Especially, M1‐type macrophages at the wound site can trigger a cascade of inflammatory responses, mediating a vicious cycle of inflammation. Meanwhile, hypoxia further exacerbates vascular damage and constriction in the wound microenvironment, thereby ...
Xianfeng Wang   +6 more
wiley   +1 more source

Whole Genome and Single‐Cell RNA Sequencing Reveals Clonal Evolution and Heterogeneity of Secondary Plasma Cell Leukemia: A Case Report

open access: yeseJHaem, Volume 7, Issue 1, February 2026.
ABSTRACT Secondary plasma cell leukemia (sPCL) is a rare, aggressive manifestation of multiple myeloma (MM). We report a 75‐year‐old Japanese man with anemia as the chief complaint and IgG‐λ MM that rapidly progressed to sPCL. Whole genome sequencing using Canopy revealed a major clone with a monoallelic TP53 mutation.
Tomotaka Suzuki   +4 more
wiley   +1 more source

Multi‐Functional S‐HA/ASTA NPs Coating on Biodegradable ZE21B Alloy for Cerebrovascular Applications

open access: yesRare Metals, Volume 45, Issue 2, February 2026.
ABSTRACT Magnesium (Mg) and its alloys have attracted extensive attention of researchers in the field of cerebrovascular implants due to their good mechanical properties and biosafety. However, rapid degradation and delayed endothelialization pose challenges. To address these issues, this study introduces a multifunctional composite coating.
Aqeela Yasin   +4 more
wiley   +1 more source

Evaluation of Chlorhexidine‐Containing Shampoos: In Vitro Efficacy Against Staphylococcus pseudintermedius and Lathering Ability

open access: yesVeterinary Dermatology, Volume 37, Issue 1, Page 148-160, February 2026.
Background: The antibacterial efficacy of chlorhexidine shampoo is directly affected by formulation and bathing factors. Hypothesis/Objective: To evaluate the in vitro antibacterial efficacy of chlorhexidine‐containing shampoos at various dilutions and to compare their lathering ability.
Emily E. Binversie   +2 more
wiley   +1 more source

World Association for Veterinary Dermatology Consensus Statement for Diagnosis, and Evidence‐Based Clinical Practice Guidelines for Treatment and Prevention of Canine Leishmaniosis

open access: yesVeterinary Dermatology, Volume 36, Issue 6, Page 723-787, December 2025.
Hyperkeratosis of (a) the footpads and (b) the nasal planum. ABSTRACT Background Canine leishmaniosis (CanL) due to Leishmania infantum remains common, and veterinarians do not always follow scientifically sound approaches for diagnosis, treatment and prevention. Objectives To provide consensus guidelines for diagnosis and evidence‐based guidelines for
Manolis N. Saridomichelakis   +9 more
wiley   +1 more source

Machine Learning‐Based Predictive Modeling Maximizes the Efficacy of mTOR/p53 Co‐Targeting Therapy Against AML

open access: yesCancer Science, Volume 116, Issue 11, Page 3040-3051, November 2025.
Although mTOR inhibitors show limited clinical efficacy against AML, this study demonstrates that combining mTOR inhibition with TP53 activation enhances anti‐leukemic effects. We also developed a gene scoring system (Rapa‐11) predicting rapamycin sensitivity and showed that monocytic AMLs with wild‐type TP53 and low Rapa‐11 scores are highly ...
Jingmei Li   +11 more
wiley   +1 more source

The Role of Histone Methyltransferase SETDB1 in Normal and Malignant Hematopoiesis

open access: yesCancer Science, Volume 116, Issue 9, Page 2331-2339, September 2025.
In this review, we discuss the role of SETDB1 in gene regulation, including an overview of its structural features and key cofactors. We also highlight the lineage‐specific roles of SETDB1 in both normal hematopoietic processes and hematological malignancies, emphasizing its function as an immune checkpoint molecule that suppresses natural killer cell ...
Yu‐Hsuan Chang, Susumu Goyama
wiley   +1 more source

旋转时间对圆环中血液形成血栓的影响

open access: yes, 2001
我们发现血液在旋转圆环中形成人工血栓存在一个极限时间:在这个时间以前,血栓的长度在增加,重量在增加;而在这个时间以后,血栓的长度不再增加,重量基本维持不变。我们称这个时间为“血栓形成的极限时间”(limittimeofthrombosis:LTT)。实验时我们将一些血液样品在旋转圆环中转动15、30和60分钟,各自得到了在旋转圆环中形成的血栓。计算结果表明,这些血栓在统计意义上有相同的长度、相同的湿重和干重。这就说明血液在旋转圆环中转动15分钟以后,形成的血栓在统计意义上血栓长度和重量不再增加了。这样 ...
钱民全   +4 more
core   +2 more sources

白鱀豚某些血液生化指标的测定

open access: yes, 1987
<正> 关于海豚和几种淡水豚类的血液学和血液生化指标国外有过研究。白鱀豚(Lipotes vexillifer)血液有形成份已有过报道。本实验对白鱀豚血液生化指标进行了研究,以期建立白鱀豚血液正常生理生化指标,为白鱀豚的临床诊断,健康监测和保健措施提供血液学参数,并且为完善淡水豚类血液学比较研究提供基础资料。材料和方法1.血样来源血样分别采自3头活体白鱀豚尾动脉。1980年1月捕获的白鱀豚(♂)“淇淇”,身体健康,从1981年7月至1986年6月(体重从36 ...
陈道权,官之梅
core  

当院における血液培養の提出状況 [PDF]

open access: yes
血液培養は感染症診療および治療に必要不可欠な検査である。また,血液培養の複数セット採取は菌の検出率を高めるだけでなく,感染性心内膜炎,デバイス感染,コンタミネーションの推定などを行える観点からも非常に重要な要素である。当院は 2012 年7 月に細菌検査室を立ち上げ,血液培養自動分析装置を導入した。そこで 2012 年度から 2018 年度の 7 年間における血液培養提出状況を調査し,経過と現状について報告を行う。 2012 年度の血液培養検査総数は3,110 セット(複数セット採取率:75.2 ...
小森 , 誠嗣   +2 more
core  

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