【目的】观察大剂量血管紧张素受体拮抗剂单独、或联合血管紧张素转换酶抑制剂治疗慢性肾小球肾炎及糖尿病肾病的疗效和安全性。【方法】40例病人按随机数字表分2组,缬沙坦组(n=20)服用缬沙坦(valsartan)320mg/d,联合组(n=20)服用盐酸贝拉普利(benazepril hydrochlofide)20mg/d联合缬沙坦160mg/d,疗程6个月。观察24h尿蛋白、血清肌酐、血压及血钾变化及不良反应情况。【结果】6个月缬沙坦组24h尿蛋白由治疗前(2.2±1.5)g/d降到(0.7±0.7)g/
李超 +4 more
doaj +2 more sources
血管紧张素转换酶、内皮型一氧化氮合酶和载脂蛋白E基因多态性与冠心病的相关性 [PDF]
[目的]研究血管紧张素转换酶(ACE)基因插入/缺失多态性、内皮型一氧化氮合酶(eNOS)基因G894T多态性和载脂蛋白E(ApoE)基因多态性与冠状动脉粥样硬化性心脏病(冠心病)的关系.[方法]应用基因芯片技术分析133例冠心病患者和122例对照者ACE、eNOS和ApoE基因多态性,对比两组基因型及等位基因频率.[结果]冠心病组ACE DD基因型频率比对照组显著升高,28.6% vs 13.1%,P<0.01,ACE基因多态性与冠心病危险性相关.两组eNOS和ApoE基因型频率差异无统计学意义(P ...
梁茜 +4 more
doaj +2 more sources
肾素-血管紧张素系统基因多态性与慢性心力衰竭的关系 [PDF]
[目的]探讨中国南方汉族人群中,血管紧张素转换酶(ACE)及血管紧张素原(AGT)双基因多态性与慢性心力衰竭发病的关系.[方法]用聚合酶链反应及限制性片段长度多态性技术检测111例慢性心力衰竭患者和110例健康者的ACE基因I/D及AGT基因M235T的多态性.[结果]①慢性心力衰竭组DD基因型与D等位基因的频率均高于对照组.DD基因型0.468比0.227,P<0.01;D等位基因0.667比0.436,P<0.01.②AGT基因M235T多态性在慢性心力衰竭组及对照组的分布无统计学差异 ...
doaj +2 more sources
Isolation, Structural Identification and in Vitro Activity Evaluation of Angiotensin-Converting Enzyme Inhibitory Peptides from Moringa oleifera Seeds [PDF]
In this study, angiotensin-converting enzyme (ACE) inhibitory peptides from an enzymatic hydrolysate of Moringa oleifera seeds were separated by sequential ultrafiltration and ion exchange chromatography.
ZHONG Yuwang, XU Wanli, FAN Yaozhu, LI Yiyan, WANG Xuefeng
core +1 more source
Serum Uric Acid and Long-term Prognosis in Patients with Acute Myocardial Infarction [PDF]
BackgroundIt is still controversial whether or not serum uric acid, a key risk for coronary heart disease, is significantly associated with prognosis of acute myocardial infarction (AMI) .
CHEN Qiang, CHEN Yingzhong, CUI Caiyan, JIANG Xinglin, ZHU Feng, LI Siyi, ZHANG Yumei, YE Tao, CAI Lin
core +1 more source
On COVID-19 and Membrane Lipids and Public Health [PDF]
Coronavirus has a lipid membrane. Whist replication requires hijacking the RNA tools of the host to synthesize virion protein, that then has to be wrapped in a lipid membrane to enable the budding off which extends the infection. Recent studies implicate
Hong-wei REN +4 more
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Clinical Effect of Early Application of Self-prescribed Yiqihuoxue Decoction on Prevention and Treatment of Depressive Symptoms after Acute Myocardial Infarction [PDF]
BackgroundPost-acute myocardial infarction (AMI) patients are prone to depression and other negative emotions. Current treatment for post-AMI patients with depression is anti-myocardial infarction treatment plus anti-depression treatment, in the ...
WANG Mengxi, LIU Qian, SHEN Le, CHEN Xiaohu
core +1 more source
Characteristics and Prognosis of Herat Failure with Improved Ejection Fraction [PDF]
BackgroundLeft ventricular ejection fraction (LVEF) is often used to classify heart failure (HF) . Some HF patients were observed to have improved ejection fraction after treatment, thus giving rise to the concept of HF with improved EF (HFimpEF ...
SU Kangkang, WANG Yan, WANG Lili, CHEN Shuxia, GU Jian
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长效降压药联合他汀类降脂药治疗高血压病的疗效观察 [PDF]
目的观察长效降压药联合他汀类降脂药治疗高血压病的临床效果。方法选取医院收治的高血压病患者132例,随机分为对照组和观察组,每组66例。对照组使用长效降压药治疗,观察组使用长效降压药联合他汀类降脂药治疗。比较2组治疗前后血压和血脂变化,出院后脑血管意外事件发生率。结果治疗后,2组收缩压、舒张压较治疗前均降低,且观察组收缩压、舒张压低于对照组 ...
洪丽娜
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Research progress on the role of vitamin D supplementation in adjuvant therapy for COVID-19 [PDF]
The pandemic caused by coronavirus disease of 2019 (COVID-19) has brought severe challenges to public health all over the world. Vitamin D plays an important role in immune regulation and anti-respiratory virus infection as an immune enhancer.
Lei Yan, Zhan Shihuai, Shi Xiaohua, Wang Shuiliang, Zhao Meng, Zhang Shenghang
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