Results 11 to 20 of about 4,526 (150)
ABSTRACT Objectives Congenital knee dislocation (CKD) is a rare condition, affecting 1 in 100 000 newborns. Its prenatal diagnosis is challenging and not well described in the literature, especially when it appears isolated and not as part of a complex malformation or syndromic pattern. The purpose of this study was to provide a comprehensive review of
P. I. Cavoretto +7 more
wiley +1 more source
A multidisciplinary approach to estimating wolf population size for long‐term conservation
Abstract The wolf (Canis lupus) is among the most controversial of wildlife species. Abundance estimates are required to inform public debate and policy decisions, but obtaining them at biologically relevant scales is challenging. We developed a system for comprehensive population estimation across the Italian alpine region (100,000 km2), involving ...
Francesca Marucco +30 more
wiley +1 more source
Abstract This longitudinal investigation evaluated parental cultural socialization practices as a central mechanism by which parents' cultural values influence developmental outcomes in ethnic–racial minority children. Drawing on a sample of 129 Latina mothers and their children (48.1% daughters and 51.9% sons), path analyses evaluated hypothesized ...
Duyen T. Trang, Tuppett M. Yates
wiley +1 more source
Highlights Interactions of environmental factors and epigenome in early life, via environmentally modified epigenetic markers, affect the transcript profiles of pancreatic islets and peripheral insulin target organs, increasing the susceptibility of developing diabetes.
Hong Zhu +3 more
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Background. With the continuous in‐depth research of Chinese medicine constitution (tizhi) and the continuous expansion of cross research with new disciplines, internationalization will become the future trend of Chinese medicine constitution (tizhi).
Siying Dong +7 more
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目的 本国际临床指南由欧洲残疾儿童学会(the European Academy of Childhood Disability,EACD)牵头制定,旨在解决发育性协调障碍(developmental coordination disorder,DCD)的定义、诊断、评估、干预以及与社会心理方面的临床应用关键问题。 方法 本指南针对五个领域的关键问题,通过文献综述和专家团队的正式讨论达成共识。为保证指南的循证基础,以“机制”、“评估”和“干预”为检索词, 对2012年更新以来提出的最新建议以及新增的“社会心理问题”和“青少年/成人”为检索词进行检索。根据牛津大学循证医学中心证据等级 (证据水平 [level of evidence, LOE]1–4) 将结果进行分类,最终转化为指南建议。并由国际 ...
Jing Hua +6 more
wiley +1 more source
Key Largo woodrats are a small and endangered island species, whose individuals tend to occur in family groups. Isolation from mainland populations, predation, and habitat fragmentation have caused genetic drift, leading to low overall diversity. Here, we found that a major category 4 hurricane promoted genetic diversity in the Key Largo woodrat ...
Taylor Ackley +5 more
wiley +1 more source
ABSTRACT Objective To evaluate the performance of non‐invasive prenatal testing (NIPT) in vanishing‐twin and multiple pregnancies. Methods This study was conducted as part of the TRIDENT‐2 study, in which NIPT was offered as a first‐tier screening test to women with a multiple pregnancy or vanishing‐twin pregnancy between 1 June 2020 and 31 March 2023 ...
J. C. A. van Eekhout +86 more
wiley +1 more source
多不饱和脂肪酸降脂作用机制的研究进展Research progress on lipid-lowering mechanism of polyunsaturated fatty acids
近年来,高脂血症患病率在全球范围内增长,多不饱和脂肪酸降脂作用的研究引起国内外学者高度关注并取得重要进展。为对深入研究多不饱和脂肪酸对血脂调节的相关机制及进一步开发多不饱和脂肪酸来源的药物或功能性食品提供参考,综述了近年来国内外对多不饱和脂肪酸降脂作用机制的研究进展,主要集中于激活脂质代谢相关转录因子及信号通路、调节炎症因子、改善氧化应激反应、提高脂联素水平、减少瘦素含量及表观遗传修饰等方面,并指出近年来多不饱和脂肪酸降脂研究中存在的共性问题。多不饱和脂肪酸作为一种独特的生物活性物质,已在降血脂、抗氧化、
王辉敏,李冠文,杨金梅,陈超,刘星,秦楠 WANG Huimin, LI Guanwen, YANG Jinmei, CHEN Chao, LIU Xing, QIN Nan
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The role of histone acetylation in Rheumatoid arthritis peripheral blood mononuclear cells [PDF]
研究背景类风湿关节炎(rheumatoidarthritis,RA)是一种常见的全身性自身免疫疾病,以慢性、进行性、侵袭性关节炎为主要临床表现。该病发病机制尚不明确,研究其发病机制对临床指导治疗具有极其深远的意义。组蛋白乙酰化在RA的发病机制中具有重要作用。组蛋白乙酰化是一种可逆的动态过程,主要由组蛋白乙酰转移酶(histoneacetylase,HATs)和组蛋白去乙酰化酶(histonedeacetylases,HDACs)协调修饰。既往研究中,Huber,L.C.等人的研究显示 ...
宋丽娜
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