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Integrative Conservation, Volume 4, Issue 4, Page 641-651, December 2025.Key Largo woodrats are a small and endangered island species, whose individuals tend to occur in family groups. Isolation from mainland populations, predation, and habitat fragmentation have caused genetic drift, leading to low overall diversity. Here, we found that a major category 4 hurricane promoted genetic diversity in the Key Largo woodrat ...
Taylor Ackley +5 more
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Ultrasound in Obstetrics &Gynecology, Volume 66, Issue 6, Page 738-746, December 2025.ABSTRACT Objective To evaluate the performance of non‐invasive prenatal testing (NIPT) in vanishing‐twin and multiple pregnancies. Methods This study was conducted as part of the TRIDENT‐2 study, in which NIPT was offered as a first‐tier screening test to women with a multiple pregnancy or vanishing‐twin pregnancy between 1 June 2020 and 31 March 2023 ...
J. C. A. van Eekhout +86 more
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多不饱和脂肪酸降脂作用机制的研究进展Research progress on lipid-lowering mechanism of polyunsaturated fatty acids
Zhongguo youzhi, 2023 近年来，高脂血症患病率在全球范围内增长，多不饱和脂肪酸降脂作用的研究引起国内外学者高度关注并取得重要进展。为对深入研究多不饱和脂肪酸对血脂调节的相关机制及进一步开发多不饱和脂肪酸来源的药物或功能性食品提供参考,综述了近年来国内外对多不饱和脂肪酸降脂作用机制的研究进展，主要集中于激活脂质代谢相关转录因子及信号通路、调节炎症因子、改善氧化应激反应、提高脂联素水平、减少瘦素含量及表观遗传修饰等方面，并指出近年来多不饱和脂肪酸降脂研究中存在的共性问题。多不饱和脂肪酸作为一种独特的生物活性物质，已在降血脂、抗氧化、
王辉敏，李冠文，杨金梅，陈超，刘星，秦楠 WANG Huimin, LI Guanwen, YANG Jinmei, CHEN Chao, LIU Xing, QIN Nan
doaj +1 more source
The Effects and Mechanisms of JMJD1A on Colorectal Tumorigenesis [PDF]
, 2015 结直肠癌（colorectalcancer，CRC）是当今世界高发恶性肿瘤之一，多数由散发腺瘤阶段性发展而来，少数结肠癌的发生呈家族性聚集现象或由炎性肠病诱导发生。对结肠癌的早期筛查与诊断是结肠癌防治重点，由于结肠癌患者个体间差异性大，对靶向药物的开发是未来结肠癌治疗的重要辅助手段。 组蛋白去甲基化酶JMJD1A(Jumonjidomaincontaining1A)通过羟基化作用使组蛋白赖氨酸去甲基进而行使转录调节功能，参与精子生成、能量代谢、干细胞更新调控，也参与低氧诱导下的肿瘤调控 ...
苗萌萌
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China's Eco‐Civilisation, Climate Leviathan, and Hobbesian Energy Transition
Antipode, Volume 57, Issue 3, Page 830-861, May 2025.Abstract Scholars have hitherto tended to theorise China's ecological civilisation project either as a form of environmental authoritarianism or as a vision of eco‐socialism. This paper contributes to the conversation by conducting a textual analysis of Chinese scholarly discussions on eco‐civilisation.
David Chen
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Lung epithelial cell differentiation in human and mouse:Environment, epigenetics and epigenetic editing [PDF]
, 2016 Roken tijdens de zwangerschap verhoogt het risico op ontwikkeling van astma op de kinderleeftijd. Daarnaast lijkt roken tijdens de zwangerschap een risicofactor te zijn voor ontwikkeling van de chronische rook-gerelateerde longziekte COPD (chronisch ...
Song, Juan
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Zhongguo shiyan zhenduanxue, 2017 表观遗传学是研究在基因的核苷酸序列不发生改变的情况下,基因发生了可遗传的表达的一门新兴学科。其机制主要包括DNA甲基化,组蛋白修饰,代谢记忆,RNA介导的基因沉默,染色质重塑及基因组印记等。糖尿病是以高血糖及胰岛素缺乏为特征的一种多因素的慢性代谢性疾病,与基因及环境因素相关[1]。近几年,越来越多的研究表明 ...
燕艳, 刘仲祥, 张秀娟
doaj
DNA甲基化与高血压的相关性研究进展 Progress of the Relationship between DNA Methylation and Hypertension
Zhongguo cuzhong zazhi, 2023 高血压是缺血性卒中最常见的可调节危险因素之一，作为一种多病因、高度异质性的疾病，环境、遗传因素在高血压的发生、发展过程中发挥着重要作用。基因与环境之间的相互作用，也就是表观遗传修饰可能介导遗传因素、环境因素和缺血性卒中之间的关系，但具体机制仍不明确。表观遗传修饰包括DNA甲基化、组蛋白修饰、染色质重塑等，其中DNA甲基化是表观遗传的重要组成部分，也是研究相对成熟的机制。DNA甲基化可以调节基因的表达，同时也受环境因素的影响。本文介绍了DNA甲基化在高血压相关病理生理机制 ...
侯叶叶, 周宏宇, 李子孝
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Reprogramming of global histone methylation controls the differentiation of monocytes into macrophages [PDF]
, 2016 单核-巨噬细胞系统由一类具有吞噬功能的免疫细胞组成，包括单核细胞、巨噬细胞及树突状细胞，是机体免疫系统重要的组成之一。来源于造血干细胞的单核细胞在趋化因子激活下，分化为巨噬细胞和树突状细胞，参与机体防卫。目前有关单核-巨噬细胞分化的细胞学过程已基本阐释，然而分化进程中关键分子及其调控网络仍需要深入阐明。此外，单核细胞如果过度增生，会导致正常造血功能衰竭。白血病的发生也与单核-巨噬细胞系统的异常发展有关。因此，深入探索和阐明单核/巨噬细胞形成过程中关键转录因子及其调控网络 ...
王慧敏
core
Wildlife Letters, Volume 2, Issue 2, Page 73-82, June 2024.Molecular markers are widely used in conservation genetics of wildlife. A total of 15 novel microsatellite loci with high polymorphism of Blue‐crowned laughingthrush were developed in this study. The genetic diversity level of wild individuals was higher than two captive populations including Ocean Park Hong Kong and Nanchang Zoo. The genetic diversity
Xinghe Gao +8 more
wiley +1 more source