Olfactory dysfunction is a risk factor for the comorbidity of mild cognitive impairment and Type 2 diabetes mellitus. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2021 Gong L +5 more
europepmc +1 more source
中西医结合护理Objective To explore the status quo and influencing factors of cancer-related cognitive impairment (CRCI)in patients with bone metastasis. Methods From December 2023 to December 2024, 139 patients with bone metastasis in Chongqing cancer hospital were ...
ZHAO Lingling (赵玲玲) +3 more
doaj +1 more source
Feature of cognitive dysfunction in patients with temporal lobe epilepsy and its clinical influencing factors. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2021 He J +5 more
europepmc +1 more source
Zhongguo shiyan zhenduanxue, 2019 随着社会老龄化的加重,术后认知功能障碍(POCD)的发生率逐年升高,并对患者的预后以及所在社区的经济造成严重影响。自1995年贝德福德首次描述了与POCD一致的术后症状。随后,学者们纷纷致力于研究术后认知功能障碍的病因。鉴于手术和麻醉后继发的神经炎症和氧化应激的作用,人们越来越了解其潜在的病理生理学机制 ...
李秀丽 +4 more
doaj
[Dysbiosis of Gut Microbiota in Patients with Post-Stroke Cognitive Impairment]. [PDF]
Sichuan Da Xue Xue Bao Yi Xue Ban, 2021 Feng RJ, Yu Q, Li Y, Feng D, Li YM.
europepmc +1 more source
The Role of Cdk5 in neuronal death and synaptic dysfunctions through phosphorylating FOXO1 and BAG3 [PDF]
, 2016 细胞周期蛋白依赖性激酶5（Cyclin-dependentkinase5，Cdk5）是由脯氨酸介导的丝氨酸/苏氨酸蛋白激酶，其在神经系统中发挥着重要的作用。Cdk5的活化主要靠神经系统中广泛表达的两个激活因子p35和p39。Cdk5对神经系统的正常生理功能具有重要作用去，其可通过磷酸化众多底物的丝氨酸/苏氨酸位点，在神经元的迁移分化，突触传递，轴突树突的发育过程以及神经元的存活中都发挥着重要的作用。此外，在某些病理条件下，Calpain所介导的p35切割形成p25，可以过度激活Cdk5 ...
周杰超
core
Prevention of dexmedetomidine on postoperative delirium and early postoperative cognitive dysfunction in elderly patients undergoing hepatic lobectomy. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2022 Tang Y +5 more
europepmc +1 more source
Amyloid-β induces microglial migration by binding to the triggering receptor expressed on myeloid cells 2 (TREM2) [PDF]
, 2017 髓系细胞触发受体2（Triggeringreceptorexpressedonmyeliodcells2，TREM2）是一种先天免疫受体蛋白，在大脑内主要表达于小胶质细胞表面。据报道，TREM2编码区的突变能够增加罹患阿尔兹海默症（Alzheimer’sDisease，AD）、纳苏-哈科罗症（Nasu-HakolaDisease，NHD）和其他神经退行性疾病的风险。虽然有许多TREM2的配体陆续被报道，但目前关于内源性TREM2配体的鉴定及其生理学功能的研究仍然知之甚少。 在本研究中 ...
王总奇
core
Cuta deficiency causes memory impairments in middle-aged mice [PDF]
, 2016 阿尔茨海默症（AD）发病机制的核心是具有神经毒性的淀粉样蛋白（Aβ）在大脑中的过度堆积。Aβ是由淀粉样蛋白前体蛋白（APP）经过β-分泌酶（β-secretase或BACE1）和γ-分泌酶（γ-secretase）的顺序切割加工而成。CUTA是CutA二价阳离子耐受蛋白，参与调控乙酰胆碱酯酶在细胞内的聚合和转运。本实验室的前期研究发现CUTA和BACE1相互作用，并调节BACE1在细胞中的定位以及Aβ的生成。为了在体内研究CUTA的作用，本实验室构建了Cuta基因敲除的小鼠模型 ...
石准
core
Progress of olfactory changes in metabolic diseases and the mechanisms [PDF]
Metabolic disorders, characterized by a complex pathogenesis, are experiencing a rising prevalence globally and a trend toward younger populations, making them a significant public health concern.
LI Huating, WU Qian
core +1 more source