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The impact of pitolisant, an H3 receptor antagonist/inverse agonist, on perirhinal cortex activity in individual neuron and neuronal population levels

Scientific Reports, 2022
Histamine is a neurotransmitter that modulates neuronal activity and regulates various brain functions. Histamine H3 receptor (H3R) antagonists/inverse agonists enhance its release in most brain regions, including the cerebral cortex, which improves ...
Kyosuke Hirano, Yoshikazu Morishita, Masabumi Minami, Hiroshi Nomura   +3 more
doaj   +1 more source

The impact of economic freedom on COVID-19 pandemic control: the moderating role of equality

Globalization and Health, 2022
Background The absence of pharmaceutical interventions made it particularly difficult to mitigate the first outbreak of coronavirus disease 2019 (COVID-19).
Guanglv Huang, Xiaoli Yu, Qinyi Long, Liqin Huang, Siyang Luo   +4 more
doaj   +1 more source

Functional Cognitive Disorders (FCD): How Is Metacognition Involved?

Brain Sciences, 2021
Functional cognitive disorders (FCD) have become a subject of increasing clinical interest in recent years, in part because of their high prevalence amongst patients attending dedicated memory clinics.
Andrew J. Larner
doaj   +1 more source

Correction: Who Lives Where and Does It Matter? Changes in the Health Profiles of Older People Living in Long Term Care and the Community over Two Decades in a High Income Country.

PLoS ONE, 2016
[This corrects the article DOI: 10.1371/journal.pone.0161705.].
Cognitive Function and Ageing Studies (DFAS)
doaj   +1 more source

Dimension of visual information interacts with working memory in monkeys and humans

Scientific Reports, 2022
Humans demonstrate behavioural advantages (biases) towards particular dimensions (colour or shape of visual objects), but such biases are significantly altered in neuropsychological disorders.
Daniel J. Fehring, Alexander J. Pascoe, Zakia Z. Haque, Ranshikha Samandra, Seiichirou Yokoo, Hiroshi Abe, Marcello G. P. Rosa, Keiji Tanaka, Tetsuo Yamamori, Farshad A. Mansouri   +9 more
doaj   +1 more source

Codex (Cognitive Disorders Examination) Decision Tree Modified for the Detection of Dementia and MCI

Diagnostics, 2019
Many cognitive screening instruments are available to assess patients with cognitive symptoms in whom a diagnosis of dementia or mild cognitive impairment is being considered. Most are quantitative scales with specified cut-off values.
Besa Ziso, Andrew J. Larner
doaj   +1 more source

The incidence of dementia in England and Wales: findings from the five identical sites of the MRC CFA Study.

PLoS Medicine, 2005
BackgroundAlthough incidence of dementia is known to vary between nations, variation within country has not been explored because most incidence studies are single site or have insufficient numbers to compare sites. Few countries have conducted multisite
Fiona Matthews, Carol Brayne, Medical Research Council Cognitive Function and Ageing Study Investigators   +2 more
doaj   +1 more source

“You’ve got a friend in me”: can social networks mediate the relationship between mood and MCI?

BMC Geriatrics, 2017
Background Social networks can change with age, for reasons that are adaptive or unwanted. Social engagement is beneficial to both mental health and cognition, and represents a potentially modifiable factor.
Jennifer A. Yates, Linda Clare, Robert T. Woods, The Cognitive Function and Ageing Study: Wales   +3 more
doaj   +1 more source

Cognitive Function Before and After Left Heart Catheterization

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundHospital procedures have been associated with cognitive change in older patients. This study aimed to document the prevalence of mild cognitive impairment in individuals undergoing left heart catheterization (LHC) before the procedure and the ...
David A. Scott, Lisbeth Evered, Paul Maruff, Andrew MacIsaac, Sarah Maher, Brendan S. Silbert   +5 more
doaj   +1 more source

Efficiency Index for Binary Classifiers: Concept, Extension, and Application

Mathematics, 2023
Many metrics exist for the evaluation of binary classifiers, all with their particular advantages and shortcomings. Recently, an “Efficiency Index” (EI) for the evaluation of classifiers has been proposed, based on the consistency (or matching) and ...
Andrew J. Larner
doaj   +1 more source