Results 41 to 50 of about 6,805,995 (208)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Evolution of cognitive function via redeployment of brain areas [PDF]

, 2006
The creative re-use of existing cognitive capacities may have played a significant role in the evolutionary development of the brain. There are obvious evolutionary advantages to such redeployment, and the data presented here confirm three important ...
Anderson, Prof. Michael L.
core  

Death-associated protein kinase 1-dependent SENP1 degradation increases tau SUMOylation and leads to cognitive dysfunction in a mouse model for tauopathy

Molecular Neurodegeneration
Background Emerging evidence implicates that tau SUMOylation disrupts tau homeostasis. Death-associated protein kinase 1 (DAPK1) has been shown to affect tau phosphorylation and accumulation.
Xindong Shui, Xiaoqing Zheng, Jinfeng Wu, Mi Zhang, Gamin Kim, Renxuan Chen, Lianlian Peng, Zonghai Wang, Yameng Zheng, Ling Zhang, Ruomeng Li, Long Wang, Ying Zhou, Jungho Kim, Dongmei Chen, Tao Zhang, Tae Ho Lee   +16 more
doaj   +1 more source

The structural and functional brain alternations in tobacco use disorder: a systematic review and meta-analysis

Frontiers in Psychiatry
BackgroundWhile numerous previous studies have indicated that nicotine intake results in gray matter and functional brain abnormalities in tobacco use disorder (TUD), the majority of results could not be replicated or even reversed.
Longyao Ma, Longyao Ma, Qiuying Tao, Qiuying Tao, Jinghan Dang, Jinghan Dang, Jieping Sun, Jieping Sun, Xiaoyu Niu, Xiaoyu Niu, Mengzhe Zhang, Mengzhe Zhang, Yimeng Kang, Yimeng Kang, Weijian Wang, Weijian Wang, Jingliang Cheng, Jingliang Cheng, Yong Zhang, Yong Zhang   +19 more
doaj   +1 more source

Dementia before death in ageing societies--the promise of prevention and the reality.

PLoS Medicine, 2006
BackgroundDementia and severe cognitive impairment are very closely linked to ageing. The longer we live the more likely we are to suffer from these conditions.
Carol Brayne, Lu Gao, Michael Dewey, Fiona E Matthews, Medical Research Council Cognitive Function and Ageing Study Investigators   +4 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Nut consumption for vascular health and cognitive function [PDF]

, 2014
Nuts are rich in many nutrients that can benefit multiple cardiometabolic functions, including arterial compliance, blood pressure, inflammation, glucoregulation and endothelial vasodilatation. Impaired vasodilatation may contribute to impaired cognitive
Coates, Alison M., Howe, Peter R. C., Coates, A., Buckley, Jonathan D., Barbour, J., Barbour, Jayne A., Howe, P., Bryan, J., Bryan, Janet, Buckley, J.   +9 more
core   +1 more source

Controlling Video Stimuli in Sign Language and Gesture Research: The OpenPoseR Package for Analyzing OpenPose Motion-Tracking Data in R

Frontiers in Psychology, 2021
Researchers in the fields of sign language and gesture studies frequently present their participants with video stimuli showing actors performing linguistic signs or co-speech gestures.
Patrick C. Trettenbrein, Patrick C. Trettenbrein, Emiliano Zaccarella   +2 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

"Davies2018_OPEN_DATASET_summary_results.txt" - Data supporting paper Davies et al. "Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function."

, 2019
Data supporting paper Davies et al "Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function." Nature Communications DOI: 10.1038/s41467-018-04362-x .
Lam, M, Davies, G, Lencz, T, Deary, IJ
core   +1 more source