Results 41 to 50 of about 1,052,447 (319)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Dual-site spatiotemporal and simultaneous inhibition on PIN1 via arsenic-retinoic albumin nanoparticles enables synergistic oncotherapy

Journal of Nanobiotechnology
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) is a master regulator of oncogenic signaling, uniquely catalyzing the isomerization of phosphorylated Ser/Thr-Pro motifs to drive malignant transformation, proliferation, and metastasis ...
Dayun Yang, Jianping Wang, Ruoru Liu, Jinfa Chen, Haiying Wen, Yu Li, Bo Lu, Zhao Guo, Daxiang Cui, Lee Jia, Haiyan Dong   +10 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Cognitive Functions of the Cerebellum [PDF]

Neuropsychology Review, 2010
The cerebellum, the often forgotten “little brain” at the back the cerebrum, has gained significant attention in the last two decades (Desmond, 2010). Although traditionally considered limited in function to component processes of motor control, astute clinicians and researchers posited that such a highly organized brain structure composed of ...
openaire   +2 more sources

Power and cognitive functioning [PDF]

Current Opinion in Psychology, 2020
Because powerful people's thinking is impactful, it is critical to understand how power affects cognition. We detail how recent empirical findings reveal that power often improves cognitive functioning. First, power increases controlled processing, in particular intentionality.
Yin, Yidan, Smith, Pamela K
openaire   +4 more sources

Altered local intrinsic neural activity and molecular architecture in internet use disorders

Brain Research Bulletin
Background: Internet gaming disorder (IGD) is mainly characterized by its core dysfunction in higher-order brain cortices involved in inhibitory control, whose neurobiological basis remains unclear.
Longyao Ma, Qiuying Tao, Jinghan Dang, Jieping Sun, Xiaoyu Niu, Mengzhe Zhang, Yimeng Kang, Weijian Wang, Jingliang Cheng, Shaoqiang Han, Yong Zhang   +10 more
doaj   +1 more source

Controlling Video Stimuli in Sign Language and Gesture Research: The OpenPoseR Package for Analyzing OpenPose Motion-Tracking Data in R

Frontiers in Psychology, 2021
Researchers in the fields of sign language and gesture studies frequently present their participants with video stimuli showing actors performing linguistic signs or co-speech gestures.
Patrick C. Trettenbrein, Patrick C. Trettenbrein, Emiliano Zaccarella   +2 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

ChaC1-based drug screenings identify a synergistic lethal effect of auranofin and proteasome inhibitors in hepatocellular carcinoma cells

Cell Death Discovery
The γ-glutamylcyclotransferase, ChaC1, is an enzyme catalyzing glutathione (GSH) degradation. In this study, we performed a ChaC1-activity-directed pharmacological screening from FDA-approved drug library to identify GSH-sensitive agents, and found that ...
Cheng Yu, Jinyu Liu, Hejia Jian, Biwen Wen, Mingting Jiang, Binghui Zhang, Meiyan Lin, Junjin Lin, Zichan Dai, Chuan-Qi Zhong, Min Zheng   +10 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source