Results 61 to 70 of about 1,052,447 (319)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Altered Resting-State Functional Connectivity in Internet Gaming Disorder: Convergent Evidence and Independent Validation

Addictive Behaviors Reports
Background: Internet gaming disorder (IGD) has attracted increasing attention worldwide. However, findings from resting-state functional connectivity (RSFC) studies have remained inconsistent, making it difficult to identify robust and reproducible ...
Jiawen Tian, Hui Zhang, Xinyu Wang, Hongyu Zhang, Longyao Ma, Bohui Mei, Mengzhe Zhang, Yan Lang, Yarui Wei, Shaoqiang Han, QingQing Lv, Yong Zhang   +11 more
doaj   +1 more source

Nut consumption for vascular health and cognitive function [PDF]

, 2014
Nuts are rich in many nutrients that can benefit multiple cardiometabolic functions, including arterial compliance, blood pressure, inflammation, glucoregulation and endothelial vasodilatation. Impaired vasodilatation may contribute to impaired cognitive
Coates, Alison M., Howe, Peter R. C., Coates, A., Buckley, Jonathan D., Barbour, J., Barbour, Jayne A., Howe, P., Bryan, J., Bryan, Janet, Buckley, J.   +9 more
core   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Diagnosis of Dementia and Cognitive Impairment

Diagnostics, 2019
In this special issue of Diagnostics, expert contributors have produced up-to-date research studies and reviews on various topics related to the diagnosis of dementia and cognitive impairment.
Andrew J. Larner
doaj   +1 more source

Multisensory task demands temporally extend the causal requirement for visual cortex in perception

Nature Communications, 2022
How primary sensory cortices contribute to decision making remains poorly understood. Here the authors report that increasing task demands extend the temporal window in which the primary visual cortex is required for detecting identical stimuli.
Matthijs N. Oude Lohuis, Jean L. Pie, Pietro Marchesi, Jorrit S. Montijn, Christiaan P. J. de Kock, Cyriel M. A. Pennartz, Umberto Olcese   +6 more
doaj   +1 more source

Multivariate pattern analysis of electroencephalography data reveals information predictive of charitable giving

NeuroImage, 2021
Charitable donations are an altruistic behavior whereby individuals donate money or other resources to benefit others while the recipient is normally absent from the context. Several psychological factors have been shown to influence charitable donations,
Qiuyan Huang, Danyang Li, Can Zhou, Qiang Xu, Peng Li, Christopher M. Warren   +5 more
doaj   +1 more source

Cross-sectional study of sleep quantity and quality and amnestic and non-amnestic cognitive function in an ageing population : the English longitudinal study of ageing (ELSA) [PDF]

, 2014
Background The aim was to investigate the association between sleep disturbances and cognitive function in younger and older individuals from an ageing population.
Wright, Hayley, Cappuccio, F. P., Francesco P Cappuccio, Miller Michelle A., Hayley Wright, Francesco P. Cappuccio (265923), Chen Ji, Chen Ji (265924), Michelle A. Miller (376857), Cappuccio Francesco P., Miller, M. A., Hayley Wright (589583), Ji Chen, Cappuccio, Francesco, Ji, Chen, Ji, C., Miller, Michelle A., Michelle A Miller, Wright Hayley, Wright, Hayley; id_orcid   +19 more
core   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source