Results 51 to 60 of about 6,805,995 (208)

Performance-Based Cognitive Screening Instruments: An Extended Analysis of the Time versus Accuracy Trade-off

Diagnostics, 2015
Early and accurate diagnosis of dementia is key to appropriate treatment and management. Clinical assessment, including the use of cognitive screening instruments, remains integral to the diagnostic process. Many cognitive screening instruments have been
Andrew J. Larner
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Altered Resting-State Functional Connectivity in Internet Gaming Disorder: Convergent Evidence and Independent Validation

Addictive Behaviors Reports
Background: Internet gaming disorder (IGD) has attracted increasing attention worldwide. However, findings from resting-state functional connectivity (RSFC) studies have remained inconsistent, making it difficult to identify robust and reproducible ...
Jiawen Tian, Hui Zhang, Xinyu Wang, Hongyu Zhang, Longyao Ma, Bohui Mei, Mengzhe Zhang, Yan Lang, Yarui Wei, Shaoqiang Han, QingQing Lv, Yong Zhang   +11 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Birth weight and cognitive function in the British 1946 birth cohort: longitudinal population based study [PDF]

, 2001
Objective To examine the association between birth weight and cognitive function in the normal population.Design A longitudinal, population based, birth cohort study.Participants 3900 males and females born in 1946.Main outcome measures Cognitive ...
Richards, M, Hardy, R, Wadsworth, MEJ, Kuh, D   +3 more
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Diagnosis of Dementia and Cognitive Impairment

Diagnostics, 2019
In this special issue of Diagnostics, expert contributors have produced up-to-date research studies and reviews on various topics related to the diagnosis of dementia and cognitive impairment.
Andrew J. Larner
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Relationship of cognitive function in patients with schizophrenia in remission to disability: a cross-sectional study in an Indian sample [PDF]

, 2007
Background: Cognitive deficits in various domains have been consistently replicated in patients with schizophrenia. Most studies looking at the relationship between cognitive dysfunction and functional disability are from developed countries.
Nayak Ajita, Ramesh R Patel, Krishnadas, R., Brian P Moore, Moore, B., Ajita Nayak, Moore Brian P, Krishnadas Rajeev, Nayak, A., Patel, R., Patel Ramesh R, Rajeev Krishnadas   +11 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

The influence of life course socioeconomic position on cognitive function and cognitive decline in older age: the impact of missing data [PDF]

, 2012
Cognitive function has been associated with many physical and mental health conditions, as well as mortality. Cognitive decline is one aspect of ageing that causes anxiety among the general population.
Landy, R
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