Results 51 to 60 of about 1,052,447 (319)

Death-associated protein kinase 1-dependent SENP1 degradation increases tau SUMOylation and leads to cognitive dysfunction in a mouse model for tauopathy

Molecular Neurodegeneration
Background Emerging evidence implicates that tau SUMOylation disrupts tau homeostasis. Death-associated protein kinase 1 (DAPK1) has been shown to affect tau phosphorylation and accumulation.
Xindong Shui, Xiaoqing Zheng, Jinfeng Wu, Mi Zhang, Gamin Kim, Renxuan Chen, Lianlian Peng, Zonghai Wang, Yameng Zheng, Ling Zhang, Ruomeng Li, Long Wang, Ying Zhou, Jungho Kim, Dongmei Chen, Tao Zhang, Tae Ho Lee   +16 more
doaj   +1 more source

The structural and functional brain alternations in tobacco use disorder: a systematic review and meta-analysis

Frontiers in Psychiatry
BackgroundWhile numerous previous studies have indicated that nicotine intake results in gray matter and functional brain abnormalities in tobacco use disorder (TUD), the majority of results could not be replicated or even reversed.
Longyao Ma, Longyao Ma, Qiuying Tao, Qiuying Tao, Jinghan Dang, Jinghan Dang, Jieping Sun, Jieping Sun, Xiaoyu Niu, Xiaoyu Niu, Mengzhe Zhang, Mengzhe Zhang, Yimeng Kang, Yimeng Kang, Weijian Wang, Weijian Wang, Jingliang Cheng, Jingliang Cheng, Yong Zhang, Yong Zhang   +19 more
doaj   +1 more source

Dementia before death in ageing societies--the promise of prevention and the reality.

PLoS Medicine, 2006
BackgroundDementia and severe cognitive impairment are very closely linked to ageing. The longer we live the more likely we are to suffer from these conditions.
Carol Brayne, Lu Gao, Michael Dewey, Fiona E Matthews, Medical Research Council Cognitive Function and Ageing Study Investigators   +4 more
doaj   +1 more source

Effects of gestational age at birth on cognitive performance : a function of cognitive workload demands [PDF]

, 2013
Objective: Cognitive deficits have been inconsistently described for late or moderately preterm children but are consistently found in very preterm children.
Jaekel, Julia, Dieter Wolke, Julia Jaekel (415253), Nicole Baumann (415254), Wolke, Dieter, Dieter Wolke (415255), Baumann, Nicole, Julia Jaekel, Nicole Baumann, Jaekel Julia, Baumann Nicole, Wolke Dieter   +11 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Relationship of cognitive function in patients with schizophrenia in remission to disability: a cross-sectional study in an Indian sample [PDF]

, 2007
Background: Cognitive deficits in various domains have been consistently replicated in patients with schizophrenia. Most studies looking at the relationship between cognitive dysfunction and functional disability are from developed countries.
Nayak Ajita, Ramesh R Patel, Krishnadas, R., Brian P Moore, Moore, B., Ajita Nayak, Moore Brian P, Krishnadas Rajeev, Nayak, A., Patel, R., Patel Ramesh R, Rajeev Krishnadas   +11 more
core   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Cognitive Function and Snoring [PDF]

Sleep, 1993
The relationship between self-reported snoring, headache and cognitive complaints (memory and concentration problems) was evaluated in an epidemiologic survey including 3,323 males, with a mean age of 63 (53-75) years. Fourteen potential confounders were examined.
P, Jennum, H O, Hein, P, Suadicani, F, Gyntelberg   +3 more
openaire   +2 more sources

Performance-Based Cognitive Screening Instruments: An Extended Analysis of the Time versus Accuracy Trade-off

Diagnostics, 2015
Early and accurate diagnosis of dementia is key to appropriate treatment and management. Clinical assessment, including the use of cognitive screening instruments, remains integral to the diagnostic process. Many cognitive screening instruments have been
Andrew J. Larner
doaj   +1 more source

"Davies2018_OPEN_DATASET_summary_results.txt" - Data supporting paper Davies et al. "Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function."

, 2019
Data supporting paper Davies et al "Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function." Nature Communications DOI: 10.1038/s41467-018-04362-x .
Lam, M, Davies, G, Lencz, T, Deary, IJ
core   +1 more source