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高脂饮食造成认知功能损伤的机制探索Mechanism exploration of cognitive impairment caused by high fat diet
Zhongguo youzhi长期的高脂饮食（HFD）会造成大脑能量代谢紊乱，引发认知障碍，影响大脑功能。旨在为膳食营养或临床手段改善HFD介导的认知功能障碍提供理论基础,系统梳理了HFD造成认知功能损伤的机制。HFD通过神经炎症、氧化应激、线粒体功能障碍、胰岛素抵抗、血脑屏障受损、表观遗传紊乱和破坏突触可塑性等途径的单一或复合作用，造成大脑认知功能受损或下降。未来研究应进一步探索大脑代谢性损伤的确切机制，并通过研究提供预防或治疗HFD造成的认知功能障碍的有效手段。 Long-term high fat diet (HFD ...
刘玲馨，王阳，朱毅 LIU Lingxin，WANG Yang，ZHU Yi
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Zhongguo shiyan zhenduanxue, 2021 围术期神经认知障碍(PND)以认知能力、记忆力、语言及社交能力的损伤为主要特点,会严重影响患者生活质量,造成住院周期延长,病死率的增加,同时增加了痴呆的风险和死亡率。PND在麻醉及手术中的出现被逐渐重视,包括了曾经术后谵妄(POD)和术后认知功能障碍(POCD)等概念在内的所有围手术期认知功能改变,在高龄、患有循环系统疾病、患有糖尿病、有家族遗传史及受教育程度较低等危险因素的基础上,麻醉及手术所引起的二次打击将促进PND的发生[1]。研究者们认为认知障碍与麻醉及手术有密切关系 ...
庄国栋, 陈艳艳, 高明
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Zhongshan Daxue xuebao. Yixue kexue ban, 2023 线粒体电压依赖性阴离子通道1（VDAC1）是线粒体外膜上重要的通道蛋白，调控线粒体自噬，参与炎症因子的调节及炎症小体的激活，从而对炎症反应起着重要的作用。睡眠呼吸暂停综合征（OSAS）患者由于间歇性缺氧，氧化应激增加引起神经炎症，导致慢性损伤和神经元细胞凋亡，最终形成认知功能障碍。由于炎症在OSAS患者认知障碍的形成过程中起着重要的作用，而VDAC1调控着炎症小体的激活，因此本文综述了OSAS与炎症、OSAS与自噬之间的关系，并分析了VDAC1介导的炎症与线粒体自噬之间的相互作用 ...
刘纯飞, 徐平
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Matrine improves neuroinflammation and diabetes-associated cognitive dysfunction in mice via mTAS2R4 activation [PDF]
Objective To investigate the effect and mechanism of matrine in improving diabetes-associated cognitive dysfunction (DACD) from activation of mouse bitter taste receptor member 4 (mTAS2R4).
Deming WANG +3 more
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Zhongguo shiyan zhenduanxue, 2015 老年性认知功能障碍与卒中均是老年致残的主要疾患,头颈部动脉狭窄与血管性认知功能障碍的研究近年比较受关注,多数文献研究认为头颈部动脉狭窄与认知功能障碍有很高的相关性,狭窄程度与认知功能障碍程度成正性相关。本文通过临床资料探讨两者的关系,为临床病情分析提供临床证据。1资料与方法1.1研究对象研究对象:均选自2013年3月-2014年3月吉林市中心医院神经内科住院患者。
孙瑜, 张小会, 魏爱宣, 张晓军
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Zhongguo shiyan zhenduanxue, 2020 脑梗死是卒中最为常见的一种类型,约占到所有卒中患者的80%,随着医疗技术的提高,病死率显著降低,但脑梗死后很多患者存在日常生活能力障碍,严重影响了患者的生活质量[1]。有研究显示脑梗死后认知功能障碍是影响日常生活能力的主要因素,而脑梗死后认知障碍的表现从轻度障碍到痴呆[2]。脑梗死引起的认知障碍除了血管性因素外,
杨宇, 蒙钟文, 张煜
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Prevalence and Distribution Trends of Mild Cognitive Impairment among Chinese Older Adults：a Meta-analysis [PDF]
, 2022 BackgroundMild cognitive impairment (MCI) has become a major disorder affecting the quality of life of Chinese older adults, a rapidly increasing population.
SHI Luping, YAO Shuihong, WANG Wei
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Research progress in mechanisms of gut microbiota in diabetic cognitive impairment and its targeted intervention [PDF]
Diabetes mellitus type 2 might cause mild cognitive impairment in its advanced stages, potentially progressing to dementia. Diabetic cognitive impairment (DCI) stands as a chronic complication of diabetes mellitus, with its underlying pathogenesis still ...
AN Yu +4 more
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Huperzine A for treatment of cognitive impairment in major depressive disorder: A systematic review of randomized controlled trials [PDF]
, 2016 Background: Acetylcholinesterase (AChE) inhibitors have been shown to be effective in treating cognitive impairment in animal models and in human subjects with major depressive disorder (MDD).
Chiu, Helen +6 more
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中西医结合护理, 2023 Objective To investigate the intervention effect of Traditional Chinese Medicine(TCM) Baduanjin exercise combined with remote ischemic conditioning therapy for patients with mild cognitive impairment in stroke.
XUE CHAO (薛超) +5 more
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