Results 11 to 20 of about 7,511 (237)
利用<bold>CRISPR/Cas9</bold>多基因编辑系统在水稻中<?Pub _newline?>快速引入遗传多样性 [PDF]
, 2017 成簇的规律间隔的短回文重复序列(CRISPR)-核酸内切酶9(CRISPR/Cas9)系统已经成为许多物种特定基因组编辑的强大工具. 利用CRISPR/Cas9多基因编辑系统成功构建共敲除水稻( Oryza sativa )中8个农艺性状基因的载体. 通过遗传转化实验和DNA测序, 发现8个基因在T0代有较高的突变效率, 并且T0代突变株的突变类型包括杂合突变和纯合突变. 此外, 还在T0代突变株中发现了纯合的六突突变株、七突突变株、八突突变株.
兰 沈 +10 more
openalex +2 more sources
[Hypothesis of Genetic Diversity Selection in the Occurrence and Development of Lung Cancer: Molecular Evolution and Clinical Significance]. [PDF]
Zhongguo Fei Ai Za Zhi, 2023 到目前为止，阐述肿瘤发生发展的单克隆假说不能自圆其说。遗传多样性选择假说将孟德尔遗传学与达尔文进化论联系起来，认为多克隆起源-单克隆选择-亚克隆扩张的肿瘤细胞群遗传多样性是选择压力的结果。正常细胞获得致癌驱动基因突变，相对于其他细胞具有选择优势，成为肿瘤启动细胞；在与肿瘤微环境（tumor microenvironment, TME）的互动中，绝大多数启动细胞会被人体自身免疫系统识别并杀灭，如果发生免疫逃逸，恶性肿瘤的发生率会极大增加，并发生亚克隆扩张、肿瘤内异质性等。本文提出遗传多样性选择假说 ...
Liu B.
europepmc +2 more sources
Wildlife Letters, Volume 1, Issue 4, Page 178-193, December 2023., 2023 Genetic analysis by scientists of hybridization events from 2006 to 2010 indicates one‐directional gene flow from polar bears to grizzly bears. Even if gene flow was later discovered from grizzly bears to polar bears, there is not enough time to allow for significant adaptation to a rapidly changing Arctic environment.
Craig L. Shafer
wiley +1 more source
A multidisciplinary approach to estimating wolf population size for long‐term conservation
Conservation Biology, Volume 37, Issue 6, December 2023., 2023 Abstract The wolf (Canis lupus) is among the most controversial of wildlife species. Abundance estimates are required to inform public debate and policy decisions, but obtaining them at biologically relevant scales is challenging. We developed a system for comprehensive population estimation across the Italian alpine region (100,000 km2), involving ...
Francesca Marucco +30 more
wiley +1 more source
Journal of Diabetes, Volume 15, Issue 11, Page 987-993, November 2023., 2023 Highlights We used data from the genome‐wide association studies database and two‐sample mendelian randomization method, we found that genetic evidence supporting that knee osteoarthritis is a potential risk factor for type 2 diabetes. Abstract Background Physical inactivity is an independent risk factor for type 2 diabetes (T2D).
Xing Xing +3 more
wiley +1 more source
Four challenges to an effective national nature assessment
Conservation Biology, Volume 37, Issue 5, October 2023., 2023 Abstract Comprehensive biodiversity assessments play an essential role in strengthening global and national conservation strategies. The recently announced first U.S. National Nature Assessment (NNA) provides an unparalleled opportunity to comprehensively review status and trends of biodiversity at all levels.
Carlos Carroll +4 more
wiley +1 more source
Integrative Conservation, Volume 2, Issue 3, Page 133-139, September 2023., 2023 Invertebrate‐derived DNA (iDNA) has enabled the identification and quantification of ecological interactions within trophic networks and its use in biodiversity assessment. The dung beetle iDNA currently uses live beetles. However, the effectiveness of the iDNA approach hinges on the successful detection of mammalian DNA from specimens collected via ...
Thilina S. Nimalrathna +3 more
wiley +1 more source
Family Process, Volume 62, Issue 3, Page 1114-1133, September 2023., 2023 Abstract This longitudinal investigation evaluated parental cultural socialization practices as a central mechanism by which parents' cultural values influence developmental outcomes in ethnic–racial minority children. Drawing on a sample of 129 Latina mothers and their children (48.1% daughters and 51.9% sons), path analyses evaluated hypothesized ...
Duyen T. Trang, Tuppett M. Yates
wiley +1 more source
Importance of timely metadata curation to the global surveillance of genetic diversity
Conservation Biology, Volume 37, Issue 4, August 2023., 2023 Abstract Genetic diversity within species represents a fundamental yet underappreciated level of biodiversity. Because genetic diversity can indicate species resilience to changing climate, its measurement is relevant to many national and global conservation policy targets.
Eric D. Crandall +23 more
wiley +1 more source
Integrating genomics and conservation to safeguard plant diversity 整合基因组学与保护生物学研究，保护植物多样性
Integrative Conservation, Volume 2, Issue 1, Page 10-18, March 2023., 2023 Abstract Conserving genetic diversity has been increasingly recognized as a keystone towards the protection of biodiversity and natural resources for future generations of humankind. In turn, the ongoing genomic revolution provides us with the technical innovations and expanded knowledge required to establish programs to integrate genomic approaches ...
Harald Schneider
wiley +1 more source