Results 11 to 20 of about 16,972 (152)

Protective effects of nattokinase against microvasculopathy and neuroinflammation in diabetic retinopathy 纳豆激酶对糖尿病视网膜病变微血管病变和神经炎症的保护作用

open access: yesJournal of Diabetes, Volume 15, Issue 10, Page 866-880, October 2023., 2023
Highlights Nattokinase rescued endothelial dysfunction and pericyte loss in the diabetic retina. Nattokinase attenuated diabetes‐induced retinal inflammation and neurodegeneration. High mobility group box 1 signaling was involved in nattokinase‐mediated retinal protection.
Zijing Huang   +11 more
wiley   +1 more source

Immunoglobulin E‐specific allergens against leaf in serum of dogs with clinical features of grass leaf allergy

open access: yesVeterinary Dermatology, Volume 34, Issue 5, Page 393-403, October 2023., 2023
Background – Grass leaf has been suspected to cause immunoglobulin (Ig)E‐mediated immediate hypersensitivity reactions both in humans and in dogs. However, most studies in this area are case control studies without in vitro data showing the involvement of IgE in the reaction.
Ken Mason, Janet Davies, Merja Ruutu
wiley   +1 more source

Increased glutamate in type 2 diabetes in the Korean population is associated with increased plasminogen levels 韩国2型糖尿病患者谷氨酸升高与纤溶酶原水平升高有关

open access: yesJournal of Diabetes, Volume 15, Issue 9, Page 777-786, September 2023., 2023
Highlights Increased glutamate is associated with the development of diabetes. Glutamate increases plasminogen (PLG) levels through glutamate metabotropic receptor 5 activation with various insulin resistance‐related stresses. Glutamate inhibits the conversion of PLG to plasmin by increasing plasminogen activator inhibitor‐1.
Hyo Jung Lee   +7 more
wiley   +1 more source

HLA‐DR3 mediated CD4 T cell response against GAD65 in type 1 diabetes patients HLA‐DR3介导的CD4 T细胞对1型糖尿病患者GAD65的应答

open access: yesJournal of Diabetes, Volume 15, Issue 7, Page 607-621, July 2023., 2023
Highlights The CD4 T cells of type 1 diabetes (T1D) patients particularly having HLA‐DRB1*03‐DQA1*05‐DQB1*02 haplotype are reactive against a particular region of the glutamic acid decarboxylase (GAD65) protein. GAD65 peptides encompassing 288–308 amino acid positions (peptide pool 2) may be favored by the HLA‐DR3 molecule for presentation to CD4 T ...
Neihenuo Chuzho   +7 more
wiley   +1 more source

β‐Cell glucokinase expression was increased in type 2 diabetes subjects with better glycemic control 血糖控制较好的2型糖尿病患者β细胞葡萄糖激酶表达增加

open access: yesJournal of Diabetes, Volume 15, Issue 5, Page 409-418, May 2023., 2023
Highlights A significant upregulation of glucokinase (GCK) expression was found in type 2 diabetes (T2D) subjects with adequate glucose control, but such increase was undetected in T2D with poor glycemic control. A strong positive correlation between GCK levels and spliced X‐box binding protein 1 (XBP1s)/activating transcription factor 4 (ATF4 ...
Jingwen Liu   +6 more
wiley   +1 more source

SWEET1‐mediated glucose transport is crucial for energy availability in Arabidopsis

open access: yesNew Phytologist, Volume 249, Issue 4, Page 1816-1830, February 2026.
Summary The stress‐responsive hormone abscisic acid (ABA) is known for its inhibitory effects on various physiological processes, including seed germination, often resulting in energy deprivation. Interestingly, ABA‐induced germination inhibition can be alleviated by exogenous glucose (Glc), mimicking a functional interplay between ABA and sugar ...
Xueyi Xue   +3 more
wiley   +1 more source

Endogenous/Exogenous Dual‐Responsive Bimetallic Hollow Nanozyme for Photothermal/Nanocatalysis/Immune Synergistic Tumor Therapy

open access: yesRare Metals, Volume 45, Issue 1, January 2026.
ABSTRACT Nanozymes have attracted considerable attention in cancer therapy due to their adjustable enzyme activity and high catalytic efficiency. However, they still face a major challenge from tumor metastasis. In this work, endogenous/exogenous dual‐responsive bimetallic hollow PdRu (termed HPdRu) nanozymes were prepared.
Nan‐Nan Zheng, Xin Hu, Jun‐Qing Hu
wiley   +1 more source

Multi‐Scale Rational Design and Synergistic Strategies of Nanozymes for Targeting Drug‐Resistant Pathogens

open access: yesRare Metals, Volume 45, Issue 1, January 2026.
ABSTRACT The escalating issue of drug‐resistant pathogens, largely driven by the overuse of conventional antibiotics, has become a significant global health threat. Developing alternative therapeutic strategies and fabricating natural biological enzyme materials that mimic the high efficiency, selectivity, and mild‐operating conditions of natural ...
Shuai He   +11 more
wiley   +1 more source

Lithology modulates soil priming effect via resource limitations and bacterial community structure

open access: yesFunctional Ecology, Volume 40, Issue 1, Page 176-190, January 2026.
Read the free Plain Language Summary for this article on the Journal blog. Abstract The soil priming effect (PE), triggered by root exudate inputs that stimulates microbial activity and drives significant soil carbon (C) losses in terrestrial ecosystems.
Xinyu Hou   +4 more
wiley   +1 more source

Nutritional and Physiological Markers Are Mediated by Seasonality and Forest Access in Captive Coquerel's Sifakas 圈养科氏冕狐猴 (Coquerel's Sifakas) 的营养和生理指标受季节性和森林通道的影响

open access: yesIntegrative Conservation, Volume 4, Issue 4, Page 652-664, December 2025.
We profiled nutritional and physiological markers in captive sifakas, endangered primates from Madagascar, managed in expansive, non‐native forest enclosures. Variation in many markers reflects freely foraged diets and the energy required to maintain homeostasis under more naturalistic conditions.
Lydia K. Greene   +5 more
wiley   +1 more source

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