Zhongshan Daxue xuebao. Yixue kexue ban铜是人体中的微量元素，与各种信号通路和肿瘤相关生物行为密切相关，但浓度超过稳态机制维持的阈值就会变得有毒，引发细胞死亡。铜死亡是一种全新的细胞死亡方式，不同于所有其他已知的细胞死亡途径，通过铜与三羧酸循环的硫辛酰化组分直接结合而发生，这导致硫辛酰化蛋白质聚集和铁硫簇蛋白丢失，引发蛋白毒性应激最终导致细胞死亡，在消化道肿瘤的发生、发展和预后中发挥作用。长链非编码RNA（lncRNA）、微小RNA（miRNA）和环状RNA（circRNA）等非编码RNA（ncRNAs ...
杜予心, 王小平
doaj
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