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China-Australia Science and Technology Forum 2010 [PDF]
, 2010 This presentation was originally in Chinese. The following is only a brief description. From metazoan to mammals, the number of protein coding genes and functional scope are broadly similar, about two million, and the functions of these genes encoding ...
Liu, Guang Bin
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miR-320a靶向Rab11a调控非小细胞肺癌细胞增殖的研究
Zhongguo shiyan zhenduanxue, 2018 非小细胞肺癌(NSCLC)是临床常见恶性肿瘤,其发病率和死亡率均居我国所有恶性肿瘤首位[1]。尽管以吉非替尼、恩度等为代表的新型靶向药物在NSCLC治疗中取得令人鼓舞的成效,但NSCLC患者的远期生存率仍不尽如人意[2]。因此,进一步探索NSCLC的发病机制,提高NSCLC的临床疗效是临床亟待解决的问题。微小RNA(miRNA)是一类内源性非编码小分子RNA,可通过靶向调控肿瘤发生发展过程中多个关键基因 ...
石少敏 +3 more
doaj
Zhongguo shiyan zhenduanxue, 2020 目的研究长链非编码RNA(long non-coding RNA,lncRNA)预测头颈部鳞状细胞癌(head and neck squamous cell carcinoma,HNSC)患者预后的作用。方法下载癌症基因组图谱(The Cancer Genome Atlas,TCGA)数据库中HNSC的lncRNA表达数据,使用edgeR包分析HNSC样本中差异表达的lncRNAs。使用COX回归分析筛选预测预后的关键lncRNAs,使用Kaplan ...
向琳, 徐晓晨, 谭君武, 杜波
doaj
H19、CHI3L1在发生侧颈淋巴结转移的甲状腺乳头状癌中的表达研究
Zhongguo shiyan zhenduanxue, 2023 目的 以发生侧颈淋巴结转移的甲状腺乳头状癌(PTC)为研讨对象，旨在找到阻断淋巴管形成、降低侧颈淋巴结转移率的方法。方法 长链非编码RNA(lncRNA)测序得出，在发生侧颈淋巴结转移的PTC中存在差异表达基因，筛选明显上调、下调的基因。结果 发生侧颈淋巴结转移的PTC中有4782个上调lncRNA,3807个下调lncRNA。结论 lncRNA H19、lncRNA CHI3L1出现明显表达差异，推测与发生侧颈淋巴结转移有关，可作为靶点构建lncRNA-X敲除慢病毒，验证是否与淋巴管形成有关。
任冰钰 +4 more
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[Research advances on the mechanism of non-coding RNA regulated diabetic wound healing]. [PDF]
Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi, 2023 Li XL, Xie JF, Ye XY, Li YG, Liu DW.
europepmc +1 more source
Function of non-coding RNA in radioresistance in non-small cell lung cancer [PDF]
Lung cancer is not only one of the most common malignancies，but also has the highest mortality rate worldwide，among which non-small cell lung cancer（NSCLC）is the most common subtype.
CHEN Mengdan, WANG Huaying, YU Wanjun
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长链非编码RNA TUG1通过调节miR-145影响宫颈癌发生发展机制研究
Zhongguo shiyan zhenduanxue目的探讨长链非编码RNA TUG1在调控miR-145表达水平的作用，分析其对于宫颈癌发生发展机制的影响。方法选取2020年1月到2023年12月新疆医科大学第一附属医院患者宫颈癌组织及细胞株，通过RT-PCR实验和qRT-PCR实验，检测长链非编码RNA TUG1、miR-145的表达水平，进行siRNA 转染、CCK-8细胞增殖检测、Annexin V-FITC流式细胞术实验以及细胞克隆形成实验，分析si-TUG1 、anti-miR-145对宫颈癌细胞株的增殖、凋亡及放射照射敏感性的影响 ...
迪 丽达尔·斯地克 +2 more
doaj
Zhongguo shiyan zhenduanxue, 2019 长链非编码RNA(LncRNA)虽然是一类不编码蛋白的RNA,但在脑组织肿瘤的形成和恶变过程中发挥重要作用,尤其是对脑胶质瘤的发生与发展有重要影响。1胶质瘤和LncRNA概述脑胶质瘤(glioma)是颅内最常见、预后极差的恶性肿瘤,存在肿瘤异质性及易感性[1,2],该病治疗困难因而死亡率很高且治疗后复发率较高,这成为困扰医务人员的一项重大疾病。针对这一问题,越来越多人开始对胶质瘤的治疗展开深入的研究和探讨。近年来,随着对胶质瘤治疗研究的逐渐深入 ...
王秀华 +4 more
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[Long non-coding RNA ABHD11-AS1 promotes glycolysis in gastric cancer cells to accelerate tumor progression]. [PDF]
Nan Fang Yi Ke Da Xue Xue Bao, 2023 Feng W, Lai Y, Wang J, Xu P.
europepmc +1 more source
Study on the mechanisms and functions of lncRNAs in regulating carboplatin resistance in ovarian cancer cells [PDF]
Objective To screen for differentially expressed long non-coding RNAs (lncRNAs) in carboplatinresistant ovarian cancer (OC) based on expression profiling microarrays and conduct functional enrichment analysis to comprehensively understand the signaling ...
CHEN Cuilan +3 more
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