Association between Polymorphisms of ERCC1 and Response in Patients with Advanced Non-small Cell Lung Cancer Receiving Cisplatin-based Chemotherapy [PDF]
, 2010 Background and objective Results of studies on genetic polymorphisms of ERCC1 gene in DNA repair pathway which may affect response to platinum-based chemotherapy and survival in patients with non-small cell lung cancer are conflicting.
Hui ZHANG +6 more
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Analysis of Differentially Expressed Proteins in Self-Paired Sera of Advanced Non-small Cell Lung Cancer Patients Responsive to Gefin [PDF]
, 2009 Background and objective All the advanced NSCLC patients that received EGFR-TKI therapy will eventually relapse after a period of efficacy. The aim of this study is to investigate the serum biomarkers as potential predictive factors for the efficacy of ...
Ailin GUO +10 more
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Extraction and identification of urine derived stem cells and its effect on adriamycin induced nephropathy in mice [PDF]
, 2016 中文摘要 目的1、提取分离和培养尿源性干细胞(USCs urine-derivedstemcells)，并鉴定其相关生物学特性。 2、通过静脉注射盐酸阿霉素建立阿霉素肾病小鼠模型。 3、通过肾组织病理观察，检测生化，应用Westernblot技术观察USCs移植和胚胎干细胞治疗保护小鼠阿霉素肾病的效果，并对尿源性干细胞在阿霉素肾病小鼠中保护作用及相关机制进行探讨。 方法1、小鼠尿源性干细胞(USCs）的提取、分离、培养与鉴定:通过收集人尿液分离出尿源性干细胞，利用离心沉淀方法分离培养，体外纯化、传代 ...
孟昕
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Study on the Roles of Long Noncoding RNA HCAL in Hepatocellular Carcinoma [PDF]
, 2016 【背景】 原发性肝癌是最常见的恶性肿瘤之一，是我国发病率和死亡率均排名第二的恶性肿瘤。原发性肝癌中，大部分为肝细胞肝癌（简称肝癌）。虽然肝癌的诊断及手术切除、放化疗等治疗手段取得了很大的进步，但肝癌患者总体的生存率仍不理想。近年来，对肝癌的分子生物学机制进行了多方面的研究，并证实肝癌的发生发展伴随着一系列分子表达的失调及信号通路的异常。因此，从分子水平深入探讨肝癌发生发展及转移的机制，对寻找早期诊断、预测预后的生物标志物和治疗的分子靶点具有重要的临床意义。 长链非编码RNA ...
谢程融
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Analysis on Lung Cancer Survival from 2001 to 2007 in Qidong, China [PDF]
, 2011 Background and objective Lung cancer is one of the most important malignancies in China. Survival rates of lung cancer on the population-based cancer registry for the years 2001-2007 in Qidong were analysed in order to provide the basis for the prognosis
Jian ZHU +4 more
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The AMP-mimetic AICAR prevents HFD-promoted hepatosteatosis and inhibits liver tumorigenesis [PDF]
, 2015 肝细胞癌（Hepatocellularcarcinoma）是最常见的肝脏原位肿瘤。肝癌的 危险因素包括酒精性肝疾病、非酒精性肝炎、肝炎病毒感染等。这些因素都和肝 癌形成中炎症有重要关系。肥胖人群中，肝脏脂质积累造成的非酒精性脂肪肝炎， 肥胖已成为肝癌形成的潜在危险因素。流行病学研究表明，超重和肥胖增加了癌 症发生的风险。在升高体重指数超标的肝癌患者中，由于肝癌死亡的风险是正常 人的4.5倍。文献报道，肥胖通过增加白介素6和肿瘤坏死因子的表达促进肝脏 炎性过程 ...
高建龙
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Diagnosis and Treatment of Tracheal or Bronchuotracheal Adenoid Cystic Carcinoma [PDF]
, 2010 Background and objective Adenoid cystic carcinoma is primary bronchopulmonary carcinoma with low malignancy, and 43 patients treated in the past 50 years in our hospital were retrospectively studied.
Daping YU +5 more
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Comparative Proteomics Study on Human High-metastatic Large Cell Lung Cancer Cell Lines Before and After Transfecting with nm23-H1 Gene [PDF]
, 2010 Background and objective As a tumor metastasis suppressor gene, the functions of nm23-H1 gene are still unclear. The aim of this study is to better understand the mechanism of lung cancer metastasis and to find new biomarkers for early diagnosis and new ...
Li MA +6 more
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The Expression and Biological Significance of PD-L1 on Lung Cancer Cell Lines [PDF]
, 2009 Background and objective Tumor-associated PD-L1 expression was recently shown to promote T-cell apoptosis and proposed as a potential mechanism of immune evasion by tumors. On the basis of the ability of tumor-associated PD-L1 to mediate activated T-cell
Cheng CHEN +6 more
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Immediate Versus Delayed Topotecan after First-line Therapy in Small Cell Lung Cancer [PDF]
, 2010 Background and objective How to prolong progression free survival (PFS) and overall survival (OS) of patients with small cell lung cancer (SCLC) has been one of the hottest issues. We retrospectively reviewed our data to compare the survival of immediate
Cong XUE +7 more
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